Thesis Abstract

Related GMR Articles

09/25/2012
Malaria; Mitochondrial DNA; Plasmodium falciparum; Plasmodium vivax; Real-time PCR

The need for a more sensitive and time-efficient assay for malaria has led to the development of molecular assays involving real-time PCR (qPCR), a procedure that has the potential to detect low levels of parasitemia, identify mixed infections, and allow for precise differentiation of species via melting curve analysis or TaqMan fluorescence-labeled probes. Since the first study published ... more

C.R.T. Souza; T.A.A. Carvalho; R.C.G. Amaral; L.S. Cunha; M.G. Cunha; J.F. Guerreiro
12/15/2017
Immune response; Malaria; Phylogenetic relationship; qRT-PCR; Resistance to insecticides
Anopheles darlingi is the most anthropophilic mosquito related to Plasmodium infection
of malaria, causing significant morbidity and mortality in South America. Pyrethroid chemical has been
used to control mosquitos. We analyzed the expression of trypsin-3 and phosrestin II genes implicated
to feeding and resistance to insecticides, immune response and ... more
Ohse; K. C; Matiolli; C. C; Scarpassa; V. M; Santos; V. S; Tadei; W. P; Rafael; M. S
02/25/2005
Body iron overload; European descent; Genetic diseases; Hereditary hemochromatosis; HFE mutations

Hereditary hemochromatosis (HH) is the most common genetic disease among individuals of European descent. Two mutations (845G®A, C282Y and 187C®G, H63D) in the hemochromatosis gene (HFE gene) are associated with HH. About 85-90% of patients of northern European descent with HH are C282Y homozygous. The prevalence of HH in the Brazilian ... more

A.L.C. Martinelli; R. Filho; S. Cruz; R. Franco; M. Tavella; M. Secaf; L. Ramalho; S. Zucoloto; S. Rodrigues; M. Zago
07/14/2009
Brazil; Hereditary hemochromatosis; HFE gene; S65C mutation

Development of hereditary hemochromatosis is asso­ciated with the C282Y, H63D or S65C mutations in the hemochro­matosis gene. Though there is extensive knowledge about the former two, there is little information on the mechanism of action and the allelic frequency of the S65C mutation. We examined the prevalence of the S65C mutation of the hemochromatosis gene in Brazilians with clinical ... more

V.C. Oliveira; F.A. Caxito; K.B. Gomes; A.M. Castro; V.C. Pardini; A.C.S. Ferreira
04/27/2016
Espírito Santo-Brazil; Hereditary hemochromatosis; HFE gene; Iron metabolism disorders; Iron overload; Polymorphisms

Hereditary hemochromatosis (HH) is an autosomal recessive disorder that leads to progressive iron accumulation and may cause cirrhosis, hepatocellular carcinoma, diabetes, and heart failure. Most cases of HH have been linked to mutations in genes associated with iron homeostasis. There have been three major variants in the high Fe (HFE) gene associated with the disease: C282Y, ... more

L.N.R. Alves; E.V.W. Santos; E. Stur; A.M.A.Silva Conforti; I.D. Louro; L.N.R. Alves; E.V.W. Santos; E. Stur; A.M.A.Silva Conforti; I.D. Louro; L.N.R. Alves; E.V.W. Santos; E. Stur; A.M.A.Silva Conforti; I.D. Louro
12/16/2013
Allelic frequency; Genetic polymorphisms; Hemoglobin S; PCR-RFLP; Sickle cell disease; SNPs

Sickle cell anemia is an affection that causes chronic inflammation, with consequences for vaso-occlusion, oxidative stress and cytokine production. Genetic polymorphisms in markers involved in this process can modulate the inflammatory response, including polymorphisms -308G/A of TNFA (tumor necrosis factor alpha) and -509C/T of TGFB1 (transforming growth factor beta 1), reported to ... more

L.S. Torres; B. Júnior; D.G. Silva; C.L. Lobo; M.A. Ruiz; C.R. Bonini-Domingos
01/09/2012
Allelic frequency; Anticoagulant; Argentina; CYP2C9; Pharmacogenomics; VKORC1

Dicumarinic oral anticoagulants have a narrow therapeutic range and a great individual variability in response, which makes calculation of the correct dose difficult and critical. Genetic factors involved in this variability include polymorphisms of genes that encode the metabolic enzyme CYP2C9 and the target enzyme vitamin K epoxide reductase complex 1 (VKORC1); these polymorphisms can ... more

P. Scibona; M.A. Redal; L.G. Garfi; J. Arbelbide; P.F. Argibay; W.H. Belloso

Pages