Research Article

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Apoptosis; Endothelial progenitor cells; Ginkgo biloba extract; Superoxide dismutase

Although ginkgo biloba extract (GBE) was shown to have antioxidant effects, little has been reported on the ability to GBE to help endothelial progenitor cells (EPCs) resist oxidative stress. The present study evaluated the influence of different concentrations of GBE on superoxide dismutase (SOD) and apoptosis of diabetic peripheral blood EPCs. Twenty-five diabetic patients without any ... more

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4; 5-trisphosphate receptors; Apoptosis; Calcium; Endoplasmic reticulum; Inositol 1; Isoflurane

Isoflurane can induce widespread cytotoxicity. We hypothesized that isoflurane induces apoptosis partly by causing excessive calcium release from the endoplasmic reticulum (ER) via direct activation of inositol 1,4,5-trisphosphate receptors (IP3R). Rat pheochromocytoma cells cultured for seven days with nerve growth factor were divided into four groups: control group (C), IP ... more

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Apoptosis; Fetal membranes; Metabolic pathways; Metabolites; Proteins

In several species, placentation involves the presence of two different membranes responsible for maternal-fetal exchanges: the yolk sac and the chorioallantoic placenta. The yolk sac plays important roles in embryonic survival, mainly during the early stages of gestation. In bovine, it is a transitional membrane that is present until day 50-70 of pregnancy. Herein, we evaluated the ... more

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Apoptosis; Colorectal cancer; IL-6/JAK-STAT3 pathway; Rhizoma paridis total saponins (RPTS)

We observed the influence of different concentrations of Rhizoma paridis total saponins (RPTS) on the apoptosis of colorectal cancer cells and explored the internal mechanism involved. We determined whether RPTS influences the interleukin-6 (IL-6)/Janus kinase (JAK)-signal transducer and activator of transcription-3 (STAT3) apoptosis  molecular pathway and looked for colon cancer ... more

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Akt; Apoptosis; Caspase-3; Fyn; Swainsonine

Swainsonine (SW), an extract from Astragalus membranaceus, represents a new class of compounds that inhibit growth and induce apoptosis in a cancer model. In this study, we demonstrated the effect of Fyn on SW-induced apoptosis in 293T cells. Western blotting was used to measure the expression of the apoptosis-related factors caspase-3, Bcl-2, Bax, and the key factor Akt (also ... more

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Apoptosis; Cell proliferation; FAS ligand (FASLG); Liver regeneration; MicroRNA-21 (miR-21)

Rat liver regeneration (RLR) induced by partial hepatectomy involves cell proliferation regulated by numerous factors, including microRNAs (miRNAs). miRNA high-throughput sequencing has been established and used to analyze miRNA expression profiles. This study showed that 39 miRNAs were related to RLR through the analysis of miRNA high-throughput sequencing. Their role toward rat normal ... more

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Apoptosis; Hematoporphyrin monomethyl ether; Hypertrophic scar; Necrosis; Sonodynamic therapy

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W. Li; J.F. Fei; Q. Yang; B.L. Li; C. Lin; Q. Yue; Q.G. Meng
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AP-1; Apoptosis; MC3T3-E1 osteoblast; p38MAPK; RNA interference

We investigated the effect of p38MAPK/AP-1 (activator protein-1) signaling on the apoptosis of osteoblasts induced by high glucose. A lentivirus vector of small hairpin RNA (shRNA) targeting p38MAPK was constructed in vitro. Osteoblasts MC3T3-E1 cultured in vitro were treated with vehicle, high glucose, p38MAPK-shRNA transfection, p38MAPK inhibitor, and unrelated shRNA ... more

Z.P. Feng; H.C. Deng; R. Jiang; J. Du; D.Y. Cheng
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Apoptosis; Bcl-2/Bax; Leukemic cells; PTEN; TIEG1

We examined the effect of transforming growth factor-b inducible early gene-1 (TIEG1) on the apoptosis of leukemic cell lines and expression of B-cell lymphoma 2 (Bcl-2) and phosphatase and tensin homolog (Pten). Four leukemic cell lines (HL-60, U937, Raji, and K562) were treated with 0, 1, 5, 10, and 20 ng/mL TIEG1, respectively. The cell growth inhibitory ratio was assessed using the ... more

K. Yao; H.C. Xing; B. Wu; Y. Li; A.J. Liao; W. Yang; Z.G. Liu

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