Research Article

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04/06/2010
Familial Mediterranean fever; Male infertility; Mediterranean fever gene

Male infertility is a common barrier that prevents successful conception. There have been reports of azoospermia in men with familial Mediterranean fever, some of whom had not been treated with colchicine. Variation in this disorder could be a risk factor for amyloidosis associated with azoospermia. We determined the frequency of 6 of the most common Mediterranean fever gene mutations, ... more

E.O. Etem; D. Erol; Y. Huseyin; A. Arslan
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Androgen receptor; Chromosome X; Exon 1; Exon 4; Male infertility

The androgen receptor is encoded by a single-copy gene located in the long arm of the X chromosome (Xq11-12); it consists of eight exons and encodes an intracellular transcription factor that belongs to the steroid/nuclear receptor superfamily. Disturbances in the function of the androgen receptor can lead to several forms of male pseudohermaphroditism, such as androgen insensitivity syndrome ... more

C.O.A. Melo; A.R. Danin; D.M. Silva; J.A. Tacon; K.K.V.O. Moura; E.O.A. Costa; A.D. da Cruz
06/11/2013
estrogen; Estrogen receptor-α; Estrogen receptor-β; Male infertility; Spermatogenesis

Polymorphisms of estrogen receptor (ER) genes have been implicated in male infertility, but studies of this association have produced conflicting results. The present study was conducted to examine whether polymorphisms within the ERα and ERβ genes are susceptibility factors for human male idiopathic infertility in Chinese men. We investigated the association between the ERα gene and ... more

J. Meng; X. Mu; Y.M. Wang
12/06/2012
Haplotype; Male infertility; Single nucleotide polymorphism; UBE2B

The ubiquitin-conjugating enzyme 2B gene (UBE2B) is involved in the regular and symmetric organization of the fibrous sheath of sperm flagella. This study aimed to examine the relationship between single nucleotide polymorphisms (SNPs) in UBE2B and infertility in Northeast Chinese men. We carried out a polymerase chain reaction-restriction fragment length polymorphism ... more

Y. Hu; W. Wen; J.G. Yu; S.Q. Qu; S.S. Wang; J. Liu; B.S. Li; Y. Luo
04/27/2012
Male infertility; mtDNA mutations; Y chromosome microdeletion

Infertility affects about 10-15% of all couples attempting pregnancy with infertility attributed to the male partner in approximately half of the cases. Proposed causes of male infertility include sperm motility disturbances, Y chromosome microdeletions, chromosomal abnormalities, single gene mutations, and sperm mitochondrial DNA (mtDNA) rearrangements. To investigate the etiology of ... more

A.I. Güney; D. Javadova; D. Kırac; K. Ulucan; G. Koc; D. Ergec; H. Tavukcu; T. Tarcan
06/12/2015
Azoospermia; Male infertility; Severe oligozoospermia; Varicocele; Y chromosome microdeletion

The prevalence of Y chromosome microdeletions among azoospermic, severe oligozoospermic, moderate oligozoospermic, and mild oligozoospermic patients with varicocele-related and idiopathic infertility shows conflicting data in Asian countries. We aimed to detect this frequency in Northeast China, and investigated spermatogenic defects whether associated with varicocele or Y chromosome ... more

R.L. Dai; Y. Hou; F.B. Li; J.M. Yue; Q. Xi; R.Z. Liu
03/11/2008
composite heifers; Follicle-stimulating hormone receptor; Luteinizing hormone receptor; Restriction fragment length polymorphism; Sexual precocity

The purpose of the present research was to investigate the effects of polymorphisms of luteinizing hormone receptor (LHR) and follicle-stimulating hormone receptor (FSHR) genes, evaluated by polymerase chain reaction-restriction fragment length polymorphism in European-Zebu composite beef heifers from six different breed compositions. The polymorphism site analysis from digestion with Hha ... more

E.P. Marson; J.B.S. Ferraz; F.V. Meirelles; J.C.C. Balieiro; J.P. Eler
06/29/2015
Cloprostenol; Estrus synchronization; Follicle-stimulating hormone receptor; Mice; Pregnant mare serum gonadotropin; Uterine development

This study investigated the effects of pregnant mare se­rum gonadotropin (PMSG) and cloprostenol (CLO) on estrus induc­tion and synchronization, uterine development, and follicle-stimulating hormone receptor (FSHR) expression in mice. A total of 105 Kunming pre-puberty mice were divided into seven subgroups. Three PMSG sub­groups were injected intraperitoneally with 10, 20, and 40 IU PMSG ... more

S. Wei; Z. Gong; L. An; T. Zhang; H. Dai; S. Chen
07/27/2015
Follicle-stimulating hormone receptor; Number born alive; Pig; Polymorphism; Total number born

Follicle-stimulating hormone (FSH), a glycoprotein secreted by the anterior pituitary, can regulate ovarian function through the FSH receptor (FSHR). To evaluate the effects of the FSHR gene on reproductive traits in pigs, polymorphisms in exon 10 of the FSHR gene were observed by polymerase chain reaction-single-strand conformation polymorphism, and 3 single ... more

X.D. Zhang; H.Y. Zhu; J. Zhou; N. Wang; N. Zhou; L. Huang; T. Wu; Y.F. Feng; Y.Y. Ding; Z.J. Yin
12/14/2011
Gene set enrichment analysis; Meta-analysis; Prostate cancer

Prostate cancer is one of the most common male malignant neoplasms; however, its causes are not completely understood. A few recent studies have used gene expression profiling of prostate cancer to identify differentially expressed genes and possible relevant pathways. However, few studies have examined the genetic mechanics of prostate cancer at the pathway level to search for such ... more

Q.Y. Ning; J.Z. Wu; N. Zang; J. Liang; Y.L. Hu; Z.N. Mo

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