Research Article

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12/15/2011
Human leukocyte antigen; Meta-analysis; Polymorphism; Psoriasis; Risk

Numerous studies have evaluated the association between human leukocyte antigen (HLA) Cw*0602 polymorphism and psoriasis risk. However, the results have been inconsistent. We made a meta-analysis of the association between HLA-Cw*0602 polymorphism and psoriasis risk. Eighteen studies were retrieved, reporting a total of 3419 psoriasis patients and 3297 healthy controls. The associations ... more

D. Wu; Y. Wu; J.L. Liu; B. Wang; X.D. Zhang
08/13/2012
Gastric cancer; Meta-analysis; NQO1 gene; Polymorphism; Risk

The association between the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and gastric cancer has been widely evaluated, yet with conflicting results. Data were available from seven study populations involving 2600 subjects. Overall, comparison of alleles 609T and 609C indicated a significantly increased risk (46%) for gastric cancer (95% confidence interval (95 ... more

Y. Zhang; Z.T. Wang; J. Zhong
06/29/2015
Alzheimer’s disease; Apolipoprotein E; Meta-analysis; Polymorphism; PPARγ

We investigated whether Pro12Ala (C→G) and His447His (C→T) polymorphisms of the peroxisome proliferator-activated receptor gamma (PPARγ) gene are associated with susceptibility to Alzheimer’s disease (AD). We conducted a meta-analysis of the associations between the PPARγ Pro12Ala and His447His polymorphisms and AD in subjects. The meta-analysis was performed according to the ... more

Y.H. Lee; G.G. Song
04/22/2015
Meta-analysis; Methylenetetrahydrofolate reductase; Polymorphism; Psoriasis

Previous studies investigating the association between methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphisms and psoriasis risk have reported inconsistent results. The present meta-analysis aimed to comprehensively evaluate the association between MTHFR 677C/T polymorphism and psoriasis risk. The studies regarding the association between MTHFR 677C/T ... more

J.H. Qi; N. Shi; Y.J. Chen; G. Nie
04/17/2015
Angiotensin-converting enzyme; Meta-analysis; Polymorphism; Sarcoidosis

Previous reports identified an association between sarcoidosis and an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme. Our meta-analysis of articles published between March 1996 and June 2013 identified studies in the PubMed, EMBASE, and the China National Knowledge Infrastructure databases. We examined whether angiotensin-converting enzyme polymorphisms influence ... more

R. Zhu; L.Q. Bi; H. Kong; S.L. Tilley; H. Wang; W.P. Xie
12/08/2011
Colorectal cancer; Meta-analysis; Polymorphism; VEGF

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved in a number of pathologic processes, including angiogenesis, tumor growth and metastasis. Polymorphisms of the VEGF gene have been associated with susceptibility to colorectal cancer (CRC). However, the specific association still remains controversial. We made a meta-analysis of the association ... more

L.P. Zhou; H. Luan; X.H. Dong; G.J. Jin; D.L. Man; H. Shang
12/08/2011
Endometrial cancer; Meta-analysis; p53 gene; Polymorphism; susceptibility

Polymorphisms of the p53 gene have been associated with susceptibility to endometrial cancer. However, whether there is a specific association is still controversial. We investigated a possible association between p53 codon 72 polymorphism and endometrial cancer risk by conducting a meta-analysis. Publications addressing this association were selected from the Pubmed, Embase and CBM ... more

Y. Gu; X. Zhou; S.L. Zhang
12/08/2011
Head and neck cancer; Meta-analysis; Polymorphism; XPD

Several studies have investigated the association between Lys751Gln polymorphism in the xeroderma pigmentosum group D (XPD) gene and risk of head and neck cancer; however, the published results are conflicting. We conducted a meta-analysis that comprised 15 published case-control studies examining the association of head and neck cancer risk with XPD Lys751Gln ... more

H. Yuan; Y.M. Niu; R.X. Wang; H.Z. Li; N. Chen
10/13/2011
Lung cancer risk; Meta-analysis; p21; Polymorphism; Ser31Arg

The cyclin-dependent kinase inhibitor 1A (also known as p21) is thought to be involved in tumor development by mediating cell cycle arrest through the inhibition of cyclin/CDK activity. To explore the relationship of Ser31Arg polymorphism in the p21 gene with the risk of developing lung cancer, we performed an overall and stratified meta-analysis based on ethnicity, lung ... more

G. Lin; F. Fang; X.J. Yu; L. Yu
09/21/2010
Endothelial nitric oxide synthase; Essential hypertension; Meta-analysis; Polymorphism

We examined the effect of polymorphisms in the endothelial nitric oxide synthase gene on the risk for essential hypertension in a Han Chinese population through a meta-analysis of data from 15 studies. Associations between increased risk for essential hypertension and 4b/a were obtained in a dominant model and allele contrast (aa + ab vs bb: odds ratio (OR)FE = 1.26, ... more

H.G. Wang; J.L. Wang; P. Chang; F.L. Cao; X.C. Liu; Y.B. Ma; G.X. Zhai; H.Q. Gao

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