Research Article

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03/31/2015
Asthma; Meta-analysis; Polymorphism; Single nucleotide polymorphism

The IL-4R Q576R polymorphism has been reported to increase susceptibility to asthma, but the results are controversial. Thus, we performed a meta-analysis to evaluate the association of the IL-4R Q576R polymorphism and asthma risk in the Chinese Han population. A total of sixteen eligible case-control studies that evaluated the relationship between the IL-4R ... more

Z.Y. Huang; B.J. Cheng; G.J. Cai; B.F. Zhang
03/06/2015
Meta-analysis; Myocardial infarction; Polymorphism; TNF-β

Tumor necrosis factor-β (TNF-β) is an important mediator of inflammation and may play a role in the pathogenesis of myocardial infarction (MI). While several published studies have investigated the association between the C804A polymorphism in the TNF-β gene and MI risk, their results are controversial and ambiguous. In this study, we evaluated the contribution of the ... more

D.W. Suo; Q. Hu; J. Chen; Q.H. Sun; H. Guo
02/13/2015
GSTM1; Lung cancer; Meta-analysis; Polymorphism

The relationship between glutathione S-transferase M1 (GSTM1) genetic polymorphisms and lung cancer has been reported previously. However, the results are not consistent. Therefore, to clarify the association between GSTM1 polymorphisms and lung cancer, we performed a meta-analysis based on published studies. We used the Revman 5.0 software to perform literature ... more

H. Liu; H.F. Ma; Y.K. Chen
02/06/2015
Alzheimer’s disease; Angiotensin-converting enzyme gene; Low-density lipoprotein receptor-related protein gene; Meta-analysis; Polymorphism; Presenilin 1 gene

The objective of this study was to assess the associations of presenilin 1 (PS1) 1/2, angiotensin I-converting enzyme (ACE) insertion/deletion (I/D), and low-density lipoprotein receptor-related protein (LRP) C/T polymorphisms with the risk of Alzheimer’s disease (AD) in the Chinese population. PS1 1/2, ACE I/D, and LRP C/T, which are commonly investigated polymorphisms, were evaluated to ... more

L. Yang; H.H. Zhou; Y.F. Ye; X.W. Fan; Y.J. Wang; Y. Meng
02/06/2015
ADAM33; Asthma; Meta-analysis; Polymorphism

In this study, we evaluated the associations between the V4 (rs2787094 G>C) polymorphism in a disintegrin and metalloproteinase domain 33 (ADAM33) gene and asthma risk. We searched Web of Science, PubMed, Google Scholar, EBSCO, Cochrane Library, and CBM databases from inception through August 2013, without language restrictions. Meta-analysis was performed using the STATA 12.0 ... more

W. Zheng; L. Wang; X. Su; X.F. Hu
02/06/2015
Meta-analysis; Polymorphism; Primary biliary cirrhosis risk; VDR

The vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR) gene encodes a protein that functions in the transcriptional regulation of vitamin D-responsive genes and plays a role in innate immunity and adaptive immune responses. In this study, we investigated the relationship between VDR polymorphisms (BsmI, ApaI, and TaqI) and primary biliary ... more

F. Fang; J. Wang; J. Pan; G.H. Su; L.X. Xu; G. Li
01/26/2015
Insulin resistance; Meta-analysis; Obesity; Polymorphism; TNF-α

Tumor necrosis factor-α (TNF-α) promoter polymorphisms has been reported to be associated with obesity and insulin resistance and gained widespread attention. However, results obtained so far are quite conf‍‍licting. We therefore performed a meta-analysis to address this issue, basing on 17 studies from electronic databases (MEDLINE and EMBASE). No evidence of ... more

H.G. Wang; J. Yang; H. Han; F. Xu; Y. Bian; H. Zhang; J.L. Wang
08/16/2012
Bronchial carcinoma; Chronic obstructive pulmonary disease; Feature selection; Ion mobility spectrometry; Machine learning

Exhaled air carries information on human health status. Ion mobility spectrometers combined with a multi-capillary column (MCC/IMS) is a well-known technology for detecting volatile organic compounds (VOCs) within human breath. This technique is relatively inexpensive, robust and easy to use in every day practice. However, the potential of this methodology depends on successful ... more

A.C. Hauschild; J.I. Baumbach; J. Baumbach
10/31/2014
Biomarker; Chronic obstructive pulmonary disease; Protein-protein interaction network

Chronic obstructive pulmonary disease (COPD) is a growing cause of morbidity and mortality throughout the world. The purpose of our study was to uncover biomarkers and explore its pathogenic mechanisms at the molecular level. The gene expression profiles of COPD samples and normal controls were downloaded from Gene Expression Omnibus. Matlab was used for data preprocessing and SAM4.0 was ... more

Y.P. Yuan; Y.H. Shi; W.C. Gu
03/27/2015
Chronic obstructive pulmonary disease; Computed tomography; Interstitial lung disease; Peripheral lung cancer; Spicule sign

The objective of this study was to investigate the correlation between spicular signs on computed tomography (CT) scans and peripheral lung cancer (PLC) that is associated with interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD). We analyzed clinical data from 96 PLC cases and grouped patients based on whether they had interstitial pneumonia into either ILD/ ... more

L. Chen; L. Gao; W.L. Wu

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