Research Article

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06/30/2005
Antioxidant; Expressed sequence tags; Free radicals; Oxidative stress; Paracoccidioides brasiliensis; Transcription factors

Survival of pathogenic fungi inside human hosts depends on evasion from the host immune system and adaptation to the host environment. Among different insults that Paracoccidioides brasiliensis has to handle are reactive oxygen and nitrogen species produced by the human host cells, and by its own metabolism. Knowing how the parasite deals with reactive species is important to ... more

É.G. Campos; Ada Silva Dantas; Mde Macedo Brigido; Mde Macedo Brigido; M.Sueli S. Felipe; R.Santos Amo Jesuino
12/19/2011
hOGG1; Oxidative stress; Polymorphisms; XPD

Knee replacement surgery is an ischemia/reperfusion model, as it uses tourniquet applied to the knee area to stop the blood flow during the operation. Fifty patients that were undergoing elective arthroscopic knee surgery were included in our study. Human 8-oxoguanine glycosylase 1 (hOGG1) is an enzyme to repair specific DNA lesions and a good marker of hydroxyl radical damage to DNA. XPD ... more

O. İsbir; U. Gormus; H.A. Ergen; B. Cakmakoglu; Ö.T. Kahraman; N. Baykan
05/10/2011
Oxidative stress; Polymorphism; Sickle cell anemia; Superoxide dismutase

Oxidative stress may be contributory to the pathophy­siology of the abnormalities that underlie the clinical course of sickle cell anemia. We looked for a possible genetic association between the functional polymorphism Ala-9Val in the human Mn-SOD gene and sickle cell anemia. One hundred and twenty-seven patients with sickle cell anemia and 127 healthy controls were recruited into the ... more

S. Sogut; Z. Yonden; H. Kaya; S. Oktar; M. Tutanc; H.R. Yilmaz; A. Yigit; N. Ozcelik; E. Gali
07/25/2014
Glucose metabolism; Glucose transport; hydrogen peroxide; Oxidative stress; Schizosaccharomyces pombe; Thiamine

The relationship between glucose repression and the oxidative stress response was investigated in Schizosaccharomyces pombe wild type cells (972h-) and glucose repression resistant mutant type cells (ird11). We aimed to reveal the mechanism of simultaneous resistance to glucose repression and oxidative stress in ird11 mutants. ... more

B. Palabiyik; J. Ghods; O. Ucar
04/29/2014
Familial Mediterranean fever; Gene polymorphism; Glutathione peroxidase; Inflammation; Oxidative stress; Paraoxonase

Familial Mediterranean fever (FMF) is an autosomal recessive disorder and is the most frequent of the periodic febrile inflammatory syndromes. The pathogenesis of the disease is not completely understood, even though the FMF gene has been identified. Oxidative stress and inflammation may play a role in the pathogenesis of FMF. We investigated gene polymorphisms of the antioxidative ... more

F. Öktem; H. Anıl; R. Sütcü; A.E. Kuybulu
02/20/2014
Antioxidant; Inflammation; Mutation; Oxidative stress; Polymorphism; Small bowel

Celiac disease (CD) is a multifactorial, inflammatory small bowel disorder characterized by nutrient malabsorption resulting from mucosal damage, the latter induced by cereal products like barley, oat, and wheat. Oxidative stress has previously been reported to play an important role in the pathogenesis of CD. In the present study, we aimed to evaluate the frequency of polymorphisms that ... more

M. Katar; A.F. Ozugurlu; H. Ozyurt; I. Benli
03/20/2015
Abiotic stress tolerance; Anti-oxidative enzymes; Cu/Zn-SOD; Jatropha curcas; NaCl stress

Superoxide dismutases (SODs) are involved in protecting plants against diverse biotic and abiotic stresses. In the present study, a novel Cu/Zn-SOD gene (JcCu/Zn-SOD) was cloned from Jatropha curcas L. Quantitative reverse transcription-polymerase chain reaction analysis revealed that JcCu/Zn-SOD is constitutively expressed in different tissues of J ... more

Z.B. Liu; W.J. Zhang; X.D. Gong; Q. Zhang; L.R. Zhou
03/26/2002
DNA damage; DNA repair; Drug metabolism; Escherichia coli mutagenesis; Oxidative stress; Yeast

The sensitivity responses of seven pso mutants of Saccharomyces cerevisiae towards the mutagens N-nitrosodiethylamine (NDEA), 1,2:7,8-diepoxyoctane (DEO), and 8-hydroxyquinoline (8HQ) further substantiated their allocation into two distinct groups: genes PSO1 (allelic to REV3), PSO2 (SNM1), PSO4 (PRP19), and PSO5 ... more

C. Pungartnik; J. Picada; M. Brendel; J.A.P. Henriques
11/23/2005
Ala16Val polymorphism; APOE gene polymorphism; Atherosclerosis; MnSOD gene polymorphism; ox-LDL; Oxidative damage; Oxidative stress

Oxidized LDL (ox-LDL) is involved in the initiation and progression of atherosclerosis. Many factors can affect the LDL oxidation such as oxidative stress. The present study tested whether ox-LDL levels would be associated with apolipoprotein E (APOE), manganese superoxide dismutase (MnSOD) Ala16Val polymorphisms, and classic cardiovascular risk factors. ox-LDL levels were measured by ... more

M.G.V. Gottlieb; C.H.A. Schwanke; A.F.R. Santos; P.F. Jobim; I.B.M. da Cruz; D.P. Müssel
11/10/2009
G6PD deficiency; Oxidative stress; TBARS; TEAC

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an enzymopathy in which reduced NADPH concentrations are not maintained, resulting in oxidative damage. We evaluated G6PD activity, oxidative stress levels and Trolox equivalent antioxidant capacity in individuals with the A-(202G>A) mutation for G6PD deficiency. Five hundred and forty-four peripheral blood samples were screened ... more

L.S. Ondei; L.M. Silveira; A.A. Leite; D.R.S. Souza; M.A.S. Pinhel; S. Percário; R. Júnior; C.R. Bonini-Domingos

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