Research Article

Related GMR Articles

Atherosclerosis; Mitochondrial DNA; Type 2 diabetes mellitus

Hyperglycemia-induced reactive oxygen species production can cause diabetes and its complications, including atherosclerosis. The role of mitochondrial DNA variants and mitochondrial copy number in the pathogenesis of diabetic atherogenesis is not well understood. We examined 36 diabetic patients who had undergone amputation for diabetic foot and seven non-diabetic patients who had ... more

M.C. Chien; W.T. Huang; P.W. Wang; C.W. Liou; T.K. Lin; C.J. Hsieh; S.W. Weng
Atherosclerosis; Global DNA methylation; Homocysteine; Lectin-like oxidized LDL receptor-1

Homocysteine (Hcy) is an independent risk factor of atherosclerosis through its involvement with the methionine cycle. In this study, we aimed to determine the blood vessel global methylation rate in Hcy-induced atherosclerosis in apolipoprotein-E-deficient (ApoE-/-) mice, and to explore the possible mechanism of this change in endothelial cells. ApoE-/- mice were divided into a ... more

X.L. Yang; J. Tian; Y. Liang; C.J. Ma; A.N. Yang; J. Wang; S.C. Ma; Y. Cheng; X. Hua; Y.D. Jiang
Angiotensin-1; Atherosclerosis; Endothelial nitric oxide synthase; Endothelin-1; Vascular function

We investigated the therapeutic effect of Xin Mai Jia (XMJ) on atherosclerosis (AS) in rats. Rat models of AS were estab­lished by peritoneally injecting vitamin D, feeding a high-fat diet, and inducing balloon injuries in rats. The stomachs of the rats were irrigated continuously for 10 weeks with XMJ. Blood lipid- and hemorheology-related indices of blood samples were detected. Pathological ... more

P. Li; G.P. Pan; M. Jia; Q.Q. Wang; Z.G. Guo; F.R. Zhao; G.L. Lei; G.R. Wan; G.M. Wan
Coronary artery disease; Cox-2 (-765G > C); Diabetes mellitus; IL-6; Polymorphism

Coronary artery disease is one of the leading causes of mortality and diabetes mellitus is one of its main risk factors due to microvascular and macrovascular complications, such as atherosclerosis. Atherosclerosis is now known to be an inflammatory process mediated by prostaglandins and several interleukins. As both are important in inflammatory processes, we examined Cox-2 (-765G > C ... more

K.K. Ol; B. Agachan; U. Gormus; B. Toptas; T. Isbir
Diabetes mellitus; Hypertension; Polymorphism; RT-qPCR; VDR gene

RT-qPCR was used to analyze the vitamin D receptor (VDR) gene TaqI polymorphism in 100 Turkish patients with type 2 diabetes mellitus (T2DM) and hypertension compared with 100 healthy subjects, to determine whether VDR could be considered as one of the susceptibility genes for T2DM and hypertension. Genotyping was done with PCR, followed by melting curve analysis with specific fluorescent ... more

H.C. Vural; E. Maltas
Diabetes mellitus; Diabetic gastroparesis; Endothelin; Gastric evacuation rate; Irbesartan; Leptin

Diabetic gastroparesis (DG) is a common clinical complication of diabetes mellitus. Leptin may cause delayed gastric emptying in the central and peripheral pathways. Microcirculatory disturbances in the stomach make gastric smooth muscles and nerves hypoxic-ischemic, thereby impairing gastric motility. Irbesartan is an angiotensin II (ATII) receptor blocker that indirectly decreases serum ... more

L. He; Y. Sun; Y. Zhu; R. Ren; Y. Zhang; F. Wang
Diabetes mellitus; Glycosylated hemoglobin; Hospital-related hyperglycemia; Hyperglycemia

Hyperglycemia is common in critical patients and high blood glucose levels have a negative effect on their prognosis. The aim of this study was to investigate the effect of hyperglycemia and glycosylated hemoglobin (GHb) in critical patients. A total of 648 critical patients were enrolled in the study and received a random blood glucose test when they entered the emergency department. If ... more

Z.L. Zhang; X.M. Che; Z.H. Bai; W.J. Bu; L. Bai; H.H. Pei
Diabetes mellitus; Genetic polymorphisms; HNF1β; Meta-analysis; Prostate cancer

Polymorphism 17q12 rs4430796 within HNF1βis a genetic variant associated with both diabetes mellitus and prostate cancer, but findings on the correlations of rs4430796 with prostate cancer risk specifically are not in agreement, especially among diverse populations. To shed some light on the contradictory findings, therefore, we carried out a meta-analysis by pooling the ... more

Y.Z. Xiang; S.B. Jiang; J. Zhao; H. Xiong; Z.L. Cui; G.B. Li; X.B. Jin
Ala16Val polymorphism; APOE gene polymorphism; Atherosclerosis; MnSOD gene polymorphism; ox-LDL; Oxidative damage; Oxidative stress

Oxidized LDL (ox-LDL) is involved in the initiation and progression of atherosclerosis. Many factors can affect the LDL oxidation such as oxidative stress. The present study tested whether ox-LDL levels would be associated with apolipoprotein E (APOE), manganese superoxide dismutase (MnSOD) Ala16Val polymorphisms, and classic cardiovascular risk factors. ox-LDL levels were measured by ... more

M.G.V. Gottlieb; C.H.A. Schwanke; A.F.R. Santos; P.F. Jobim; I.B.M. da Cruz; D.P. Müssel
Atherosclerosis; Mononuclear cell; Stress; β2-AR

The aim of this study was to determine whether monocyte/macrophage β2-AR could act as the therapeutic target of antisympathetic excitation-induced atherosclerotic progression. Cultivated human THP-1 cells were divided into different groups and incubated with isoprenaline, metoprolol, propranolol or β2-AR blocker for 24 h, together with oxidized low-density lipoprotein (ox-LDL). Afterwards ... more

Y.L. Guo; J.Q. Zhou; C.Q. Xiang; W.H. Yang; B. Zhang; W.J. Dai; J.H. Liu; S.J. Zheng