Research Article

Related GMR Articles

Brazilian families; Cancer; CYP1A1m1 SNP; GSTM1 null

Research has shown that genetic polymorphisms in biotransformation enzymes, such as CYP1A1 and GSTM1, are related to a greater or lesser susceptibility to various cancers. We made an analysis of CYP1A1m1 SNP and GSTM1 null genotypes in a family group (71 members) related by consanguinity who had an unusually high incidence of cancer and a high frequency of smokers. There ... more

L.N. Moraes; M.F. Borges; P.A.C. Sousa; P.C. Venere; I.L. Souza
Anthracycline-related cardiotoxicity; Anthracyclines; Cancer; Carbonyl reductase 1 (cbr1); Domestic dog (Canis lupus familiaris); Doxorubicin

The anticancer anthracyclines doxorubicin and daunorubicin are used to treat a variety of cancers in dogs. The therapeutic utility of anthracyclines is limited by cardiotoxicity in some cases. Synthesis of anthracycline alcohol metabolites by carbonyl reductase 1 (CBR1) is crucial for the pathogenesis of cardiotoxicity. We hypothesize that genetic polymorphisms in canine cbr1 ... more

Q. Cheng; C. Sanborn; D. Ferguson; J.G. Blanco
Apoptosis; Cancer; Cytotoxicity; MCF-7; Saudi Arabia

This study investigated the in vitro anticancer activities of a total of 14 wild angiosperms collected in Saudi Arabia. The cytotoxic activity of each extract was assessed against human breast adenocarcinoma (MCF-7) cell lines by using the MTT assay. Among the plants screened, the potential cytotoxic activity exhibited by the extract of Lavandula dentata (Lamiaceae) was ... more

M.A. Ali; A. Farah; F.M. Al-Hemaid; F.M. Abou-Tarboush
Cancer; Chromosome aberration; DNA repair genes; Molecular epidemiology

Endometriosis is a complex disease that has both benign and malignant characteristics. It affects 5-10% of women of reproductive age. Studies have demonstrated the existence of common genetic changes in endometriosis and ovarian cancer, suggesting a possible association between these 2 diseases. However, the mechanisms that lead to the development of cancer from endometriosis remain ... more

M.S. Monteiro; D.B.Vilas Boas; C.B. Gigliotti; D.M.F. Salvadori
Cancer; Disparities; IL-6; Polymorphism; Prostate

Interleukin-6 (IL-6), a pro-inflammatory cytokine, is involved in prostate cancer progression, including androgen independence. Serum IL-6 levels also correlate with prostate tumor burden, prostate-specific antigen levels and metastasis. Since circulating cytokine levels vary considerably inter-individually, such variation could be linked to genetic factors, including genetic polymorphism ... more

S. Mandal; F. Abebe; J. Chaudhary
Cancer; Cytosolic serine hydroxymethyltransferase C1420T; Meta-analysis; Single nucleotide polymorphism

Published data regarding the association between the cytosolic serine hydroxymethyltransferase (SHMT1) C1420T (Leu474Phe) polymorphism and solid tumor risk have shown inconclusive results. To derive a more precise estimation of the relationship, we performed a meta-analysis of 23 published studies that included 14,409 cancer cases and 16,996 controls. A comprehensive search was ... more

T.T. Zhao; L.L. Shen; X.L. Zhang; D.Y. Gu; Q. Zhang; X.Y. Huo; C.J. Tang; J.F. Chen
Bioinformatics; Biomarkers; Cancer; Immunohistochemistry

Identification of cancer-associated and tissue-specific proteins is important for research on carcinogenesis mechanisms and biomarker discovery. Here we performed a new strategy to identify candidate cancer proteins by mining immunohistochemistry protein profiles. Proteins with quantitative values from 14 normal tissues and their corresponding cancer tissues were compared and analyzed ... more

X.X. Liu; F.J. Liu
Cancer; DNA (cytosine-5)-methyltransferase 3A; Meta-analysis; Single nucleotide polymorphism

Cancer is a major public health problem worldwide that involves complex processes and factors. For instance, methylation is important in tumorigenesis. DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, the -448A>G polymorphism is associated with cancer; however, the results of various studies ... more

C.H. Liu; T. Tao; L. Jiang; B. Xu; L. Zhang; K. Lu; X.W. Zhang; S.Q. Chen; D.C. Liu; M. Chen
Haplogroup; Lung cancer; Mitochondrial DNA; Somatic mutation

Mitochondrial DNA mutations play crucial roles in the pathogenesis and progression of human malignancies. Therefore, to determine whether maternal background or mitochondrial DNA somatic mutations were essential cofactors in the lung cancer of Chinese patients as well, the complete mitochondrial DNA displacement loop of the primary cancerous, matched para-cancerous normal and distant ... more

Y. Fang; H.Y. Yang; Y.H. Shi; J.H. Cui; L.Y. Li; Y.C. Xu; J.L. Shao