Research Article

Related GMR Articles

Acute lung injury; High mobility group box 1; Interleukin-6; Tumor necrosis factor α; Ulinastatin

The aim of this study was to investigate the influence of ulinastatin (UTI) on high mobility group box 1 (HMGB1), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 expression in acute lung injury (ALI) rats with sepsis caused by cecal ligation and puncture (CLP) surgery, as well as to examine the underlying biological mechanism. Thirty rats were randomly and evenly divided into sham ... more

S.Y. Wang; Z.J. Li; X. Wang; W.F. Li; Z.F. Lin
Acute pancreatitis; Chinese; Interleukin-1β; Interleukin-6

We investigated the association between 3 main proinflammatory cytokines [interleukin (IL)-1β and IL-6] and the risk of acute pancreatitis. Polymerase chain reaction-restriction fragment length polymorphism was used to genotype IL-1β+3954 C/T (rs1143634) and IL-1β-511 C/T (rs16944) and IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G ( ... more

D.Z. Chi; J. Chen; D.P. Huang
Cytokines; Gold nanoparticles; In vivo toxicity; Inflammation; Rats

Most studies have used in vitro systems to test inflammatory responses of nanoparticles; these may not reflect the real biological response of body organs. In fact, certain nanoparticles have provoked opposite effects under in vitro and in vivo conditions. Current understanding of the biocompatibility of gold nanoparticles is controversial. We studied the acute ... more

H.A. Khan; M.A.K. Abdelhalim; A.S. Alhomida; M.S.Al Ayed
Abnormal Savda syndrome; Ischemia-reperfusion injury; Munziq; Rats

To investigate the effects of different doses of abnormal Savda Munziq on myocardial ischemia-reperfusion injury (MI/RI) in rats with the abnormal Savda syndrome, 50 abnormal Savda animal models were randomly divided into a control group, a model group, a high-dose group, a middle-dose group, and a low-dose group, with each group containing 10 rats. The enzyme-linked immunosorbent assay ... more

A. Maimaitiaili; A. Shabiti; M. Abudureheman; Z. Musha; Q. Jun; G. Maimaitiaili; A. Aibibula; H. Upur
Hirudin; Intracerebral hemorrhage; Rats; Thrombin

This study aimed to investigate the effects of thrombin released in hematoma after intracerebral hemorrhage (ICH) on the cerebral injury of perihematomal tissues and to evaluate the protection effect of hirudin on the cerebral injury after ICH. We used the autologous uncoagulated blood injection method to prepare the ICH rat model, and all rats were randomly divided into a normal group, ... more

C.M. Liu; B.Z. Shi; J.S. Zhou
Different stages; HIF-1α; Rats; Thromboangiitis obliterans

We investigated the expression and effects of hypoxia-inducible factor-1α (HIF-1α) in rat thromboangiitis obliterans (TO). Rats were divided into sham and model groups. The model group was further divided into groups based on observation duration. Lauric acid was injected below an artery clamp to simulate TO in the model group; saline was used in the sham group. Clamps were removed 15 min ... more

T. He; B.H. Qu; D.L. Wang; M. Hu
Ischemia preconditioning; Ischemia-reperfusion injury; Liver transplantation; Rats

We explored the protective effect of ischemia preconditioning (IP) on ischemia-reperfusion injury in rat liver transplantation. An orthotopic liver transplantation model was utilized in the study. A total of 54 Sprague-Dawley rats were divided into a control group (group A, no liver transplantation), liver transplantation group (group B, heparin Ringer’s lactate solution was perfused via ... more

Z.S. Qing; X.S. Zhang; C.C. Gao; W.D. Liu; T.F. Xia; K. Wu; L.Q. Pang
Heat stress; HSP70; Myocardial cells; Rats

To investigate the mechanism of sudden death as a result of stress-induced damage to heart tissue and myocardial cells and to investigate the cardioprotective role of Hsp70 during heat stress, the distribution and expression of Hsp70 was evaluated in the heart cells of heat-stressed rats in vivo and heat-stressed H9c2 cells in vitro. After exposure to heat stress at 42°C ... more

H.B. Chen; X.C. Zhang; Y.F. Cheng; A. Abdelnasir; S. Tang; N. Kemper; J. Hartung; E.D. Bao
Free radical; Nimodipine; Peroxidase; Propylene glycol; Rats; Spinal cord injury

We evaluated the potentially protective effect of nimodipine on rat spinal cord injury. Sprague-Dawley rats received spinal cord injury, and were separated into nimodipine (N = 12) and saline groups (N = 12). Within 1 h of the injury, rats were treated intraperitoneally with nimodipine (1.0 mg/kg) or an equal amount of saline. Treatment was performed 3 times a day for 1 week. Operation ... more

Y.F. Jia; H.L. Gao; L.J. Ma; J. Li
Bcl-2; Breast cancer; Ketamine

Ketamine is a dissociative anesthetic agent that has been widely used in surgery and for relieving pain in chronic cancer patients. We applied ketamine to breast cancer cell line MDA-MB-231 to detect the effect of treatment and molecular mechanisms involved. We found that ketamine can upregulate the level of anti-apoptosis protein Bcl-2, which promotes breast cancer cell invasion and ... more

H. He; J. Chen; W.P. Xie; S. Cao; H.Y. Hu; L.Q. Yang; B. Gong