Brief Note

Related GMR Articles

10/05/2007
Antimicrobial peptides; Circular dichroism; Intrinsically unstructured proteins

Proteolysis-inducing factor/dermcidin (PIF/DCD) is a novel human gene, located on chromosome 12, locus 12q13.1, that encodes a secreted 110-amino acid protein. Two transcripts for the protein have been identified in normal skin, breast, placenta and brain, and in various primary and metastatic tumor cells. The putative native-state structure of PIF/DCD has not been resolved. Here, we describe ... more

G. Majczak; S. Lilla; M. Garay-Malpartida; J. Markovic; F.J. Medrano; G. de Nucci; J.E. Belizário
10/14/2008
Antimicrobial peptides; Cysteine-rich peptides; Gomesin; molecular simulations; Protegrin-1

Some antimicrobial peptides have a broad spectrum of action against many different kinds of microorganisms. Gomesin and protegrin-1 are examples of such antimicrobial peptides, and they were studied by molecular dynamics in this research. Both have a β-hairpin conformation stabilized by two disulfide bridges and are active against gram-positive and gram-negative bacteria, as well as fungi. In ... more

J.R.M. Castro; C.A. Fuzo; L. Degrève; A. Caliri
10/06/2008
Antimicrobial peptides; Dodecylphosphocholine micelle; indolicidin; indolicidin mutant; molecular dynamics simulation; peptide-micelle interaction

The antimicrobial peptide indolicidin (IND) and the mutant CP10A in hydrated micelles were studied using molecular dynamics simulations in order to observe whether the molecular dynamics and experimental data could be sufficiently correlated and a detailed description of the interaction of the antimicrobial peptides with a model of the membrane provided by a hydrated micelle system could be ... more

C.A. Fuzo; J.R.M. Castro; L. Degrève
08/13/2012
Antimicrobial peptides; Odontotermes formosanus; Reticulitermes chinensis; Termicins

Termicin is a defensin-like antimicrobial peptide of termites that has strong antifungal activity. Fifty-six different termicin mRNAs encoding 46 different peptides were amplified and identified from Odontotermes formosanus (Termitidae), a species that inhabits environments with a large variety of microbial fauna. In contrast, only 38 different termicin mRNAs encoding 21 ... more

P. Xu; M. Shi; R. Lai; X.X. Chen
10/19/2015
Antimicrobial peptides; Innate immunity; Sheep; Sheep beta defensin-2; Single nucleotide polymorphism

The northern region of Brazil produces a large number of sheep, with Pará being the largest sheep breeding state in the region. In the Amazon region, livestock production is a challenge due to the high diversity of pathogens affecting humans and animals. Defensins are antimicrobial peptides acting as a first barrier against micro-organisms and present high variation in different organisms ... more

B.B. Souza; E.M. Barbosa; J.S.N. Azevedo; J.E.G. Campelo; L.F.S. Rodrigues; L.M.L. Pinheiro; S.C.B. Silva; A.S. Schierholt; P.H. Souza; E.C. Gonçalves; S. Filho
10/24/2016
Antimicrobial peptides; Chromatography; Membrane permeabilization; Phytopathogenic fungi; Reactive oxygen species

Coffee, an agronomical crop of great economic importance, is also among the most commonly traded commodities in worldwide markets. Antimicrobial peptides, which play a role in plant defense, have been identified and isolated particularly from seeds. We isolated and immunolocalized Cc-LTP2, a new lipid transfer protein (LTP) from Coffea canephora ... more

G.C.V. Bard; U. Zottich; T.A.M. Souza; S.F.F. Ribeiro; G.B. Dias; S. Pireda; M. Da Cunha; R. Rodrigues; L.S. Pereira; O.L.T. Machado; A.O. Carvalho; V.M. Gomes; G.C.V. Bard; U. Zottich; T.A.M. Souza; S.F.F. Ribeiro; G.B. Dias; S. Pireda; M. Da Cunha; R. Rodrigues; L.S. Pereira; O.L.T. Machado; A.O. Carvalho; V.M. Gomes