Research Article

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CD36; Coronary heart disease; Risk factors; rs1049673; rs321159; rs7755

Risk factors for premature coronary heart disease in China can be multiple; we investigated Chinese Han patients with premature coronary heart disease and a possible association with CD36 polymorphism at rs1049673, rs7755, and rs321159 sites. Outpatients were recruited according to chest X-ray coronary arteriography results; they were divided into two groups: early coronary artery ... more

J.J. Che; Y.X. Shao; G.P. Li
Acylation-stimulating protein; Coronary heart disease; Han; Triglyceride; Uygur

The association of the single nucleotide polymorphism 301T>C in the coding region of the acylation-stimulating protein (ASP) gene with coronary heart disease (CHD) was investigated in the Uygur (385 CHD patients and 483 control subjects) and Han (390 CHD patients and 439 control subjects) populations of China. The frequency of the CC and CT genotypes was significantly higher in ... more

Y. Chen; Y.T. Ma; S.J. Yang; Y.N. Yang; Z.Y. Fu; X. Xie; X.M. Li; Y.Y. Zheng
Coronary heart disease; Meta-analysis; Polymorphism; PPARD; rs2016520

PPARD encodes peroxisome proliferator-activated re­ceptor delta, which has been shown to play an important role in control­ling lipid metabolism and atherosclerosis. In this case-control study, we explored the relationship between PPARD rs2016520 polymorphism and coronary heart disease (CHD) in a Han Chinese population. A to­tal of 657 CHD cases and 640 controls were included in the ... more

H.D. Ye; Y.R. Li; Q.X. Hong; A.N. Zhou; Q.L. Zhao; L.M. Xu; M.Q. Xu; X.T. Xu; L.L. Tang; D.J. Dai; D.J. Jiang; Y. Huang; D.W. Wang; S.W. Duan
Essential hypertension; Evironmental risks; Feature selection; Genetic polymorphisms; Support vector machines

Statistical modeling of links between genetic profiles with environmental and clinical data to aid in medical diagnosis is a challenge. Here, we present a computational approach for rapidly selecting important clinical data to assist in medical decisions based on personalized genetic profiles. What could take hours or days of computing is available on-the-fly, making this strategy ... more

P.C. Carvalho; S.S. Freitas; A.B. Lima; M. Barros; I. Bittencourt; W. Degrave; I. Cordovil; R. Fonseca; M.G.C. Carvalho; R.S.Moura Neto; P.H. Cabello
Amerindians; Brazilian population; DARC; DNA polymorphism; Duffy blood group; Genetic polymorphisms

Ala100Thr has been suggested to be a Caucasian genetic marker on the FY*B allele. As the Brazilian population has arisen from miscegenation among Portuguese, Africans, and Indians, this mutation could possibly be found in Euro- and Afro-Brazilians, or in Brazilian Indians. Fifty-three related individuals and a random sample of 100 subjects from the Brazilian population were investigated ... more

A.Cristina Estalote; R. Proto-Siqueira; W.Araújo Da Silva; M.Antonio Zago; M. Palatnik
Genetic polymorphisms; Lipid profile; Marker assisted selection; Molecular markers; Nellore cattle; Single nucleotide polymorphisms
F.M. Rezende
Brazilian population; Complement receptor-1; Duffy blood group; Genetic polymorphisms; Malaria; Toll-like receptor

The main purpose of this research was to analyze the relation of the genetic polymorphisms frequently expressed by antigen-presenting cells, erythrocytes and malaria susceptibility/resistance with the human malaria infection cases. The sample used consisted of 23 Plasmodium vivax (Pv)- and P. falciparum (Pf)-infected patients, and 21 healthy individuals as a control group, ... more

S.C. Soares; K. Abé-Sandes; V.B.Nascimento Filho; F.M.F. Nunes; W.A. Silva
ABCB1 gene; Genetic polymorphisms; Infantile spasms

Infantile spasms are a severe epileptic encephalopathy with a variety of etiologies that occur in infancy and early childhood. Subjects with infantile spasms are at a higher risk for evolving into intractable epileptic spasms, tending to be refractory to conventional antiepileptic drugs. Genetic polymorphisms of the P-glycoprotein-encoding gene ABCB1 are suspected to be associated with ... more

L. Dong; M. Mao; R. Luo; Y. Tong; D. Yu
AGER; Genetic polymorphisms; Gestational diabetes; RAGE; Single nucleotide polymorphisms

The receptor for advanced glycation end products (RAGE or AGER) is a multiligand member of the immunoglobulin superfamily. RAGE is expressed in several tissues, including human myometrium, chorionic villi and placenta. Advanced glycation end products are the best studied ligands of RAGE; they have pro-inflammatory actions in human gestational tissues, ... more

I.C.R. Santos; D.R. Daga; H.R. Frigeri; R.R. Réa; A.C.R. Almeida; E.M. Souza; F.O. Pedrosa; C.M.T. Fadel-Picheth; G. Picheth
Adenosine deaminase; Angiotensin-converting enzyme; Cardiovascular risk; Genetic polymorphisms; Type 2 diabetes mellitus
A.C.B. Domingos