Research Article

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12/17/2012
Gene polymorphism; LOC387715/ARMS2; Meta-analysis; Polypoidal choroidal vasculopathy

We investigated the association between the LOC387715/ARMS2 polymorphism (rs10490924 G>T) and susceptibility to polypoidal choroidal vasculopathy (PCV) through a meta-analysis of 1446 cases and 3255 controls from eight case-control studies. The genetic effect of the LOC387715/ARMS2 rs10490924 G>T polymorphism on PCV was assessed by calculating pooled odds ratios (ORs) with 95% ... more

J.J. Jiang; X. Wu; P. Zhou; W.Z. Yu; L.Z. Huang; X.X. Li
10/04/2012
Glioma risk; MDM2; Meta-analysis; p53; Polymorphisms

Epidemiological studies of the association of variants p53 Arg72Pro and MDM2 single-nucleotide polymorphism 309 (SNP309) with glioma risk have produced inconsistent results. The aim of the current study was to evaluate the association of these 2 variants with glioma susceptibility using a meta-analysis approach. For p53 Arg72Pro, 10 case-control studies including ... more

J.N. Zhang; S.H. Yi; X.H. Zhang; X.Y. Liu; Q. Mao; S.Q. Li; W.H. Xiong; Y.M. Qiu; T. Chen; J.W. Ge
09/26/2012
Arg904Gln; Essential hypertension; Meta-analysis; Polymorphisms; TSC

Although there have been several studies investigating a possible association between essential hypertension and TSC gene Arg904Gln polymorphisms, the results have been inconsistent. We conducted a meta-analysis of four case-control studies (one study in Europe and three studies in Asia), including 1811 essential hypertension cases and 1381 controls. The pooled results showed no ... more

F. Zhang; Y. Yang; D. Hu; H. Lei; Y. Wang
06/15/2012
Genetic polymorphisms; Meta-analysis; Prostate cancer; PTGS2

Evidence is accumulating that chronic inflammation has an important role in prostate cancer. Two common polymorphisms in the prostaglandin-endoperoxide synthase 2 (PTGS2) gene, rs20417 and rs689470, have been found to alter the risk for prostate cancer, but the various studies are not in agreement. To derive a more precise estimation of this association, all available studies were ... more

H.T. Zhang; Y. Xu; Z.H. Zhang; L. Li
02/08/2012
Dopamine D2 receptor; Gene polymorphism; Meta-analysis; Schizophrenia

Numerous studies have evaluated the association between Ser311Cys (rs1801028, C>G) polymorphism of the dopamine D2 receptor (DRD2) gene and schizophrenia risk. However, the specific association is still controversial. We examined whether DRD2 Ser311Cys polymorphism confers schizophrenia risk in Asian populations. Sixteen studies were retrieved reporting on a total of 2268 schizophrenia ... more

Z.W. Liu; J.L. Liu; Y. An; L. Zhang; Y.M. Wang
12/12/2014
Gastric cancer; Meta-analysis; Prognosis; S100A4

The prognostic role of S100A4 in gastric cancer is still under debate. The present meta-analysis aimed to evaluate the relationship between S10A4 levels and the prognosis of gastric cancer. We performed a meta-analysis of published studies assessing the relationship between S100A4 and gastric cancer prognosis. We used the Revman 5.0 software to perform literature retrieval, article ... more

Y. Wang; L.B. Zhou; X.H. Li
11/28/2014
Genetic polymorphism; Hypodontia; Meta-analysis; PAX9

To evaluate the association between paired box 9 (PAX9) gene polymorphisms and tooth agenesis in isolated humans, we performed a comprehensive meta-analysis. We examined 6 case-control studies, with a total of 855 hypodontia cases and 1201 healthy controls. The G allele and G carrier (AG + GG) of A1031G were positively associated with hypodontia susceptibility. Similarly, the T ... more

W. Zhang; H.C. Qu; Y. Zhang
01/24/2014
Cardiovascular disease; Meta-analysis; Myocardial infarction; Visfatin

Visfatin, an adipocytokine involved in metabolic and immune disorders, plays an important role in the etiology of cardiovascular disease. Recent evidence has shown that an elevated plasma level of visfatin may increase the risk of myocardial infarction (MI), but individual published studies have shown inconclusive results. This study aimed to obtain a more precise estimate of the ... more

Y. Yang; Z. Li; H.F. Tao; X.Y. Qi; W.L. Wang; L. Yang; H. Wang; P. Xu
09/12/2014
C677T; Gene polymorphism; Meta-analysis; Postmenopausal women

Numerous studies have evaluated the association between MTHFR C677T polymorphism and osteoporotic fracture risk in postmenopausal women. However, the results have been inconsistent. We performed a meta-analysis of the association between MTHFR C677T polymorphism and osteoporotic fracture risk in postmenopausal women. Only seven case-control studies were retrieved, with a total of 4258 ... more

J.Z. Guan; M. Wu; Y.Z. Xiao; J.S. Zhou; Z.D. Wang
02/21/2014
Colorectal cancer; Diagnosis; Meta-analysis; NGAL; Prognosis

Growing evidence has implicated that neutrophil gelatinase-associated lipocalin (NGAL) plays a role in a spectrum of human cancers. Several observational studies from different parts of the world have been devoted to elucidate the clinical relationship between NGAL and colorectal cancer. This meta-analysis aimed to explore the overall accuracy of NGAL detection for the diagnosis and ... more

Y. Wang; T.T. Zeng

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