Research Article

Related GMR Articles

07/02/2014
Antioxidant; Cancer treatment; Chemoprevention

We evaluated the effects of glutamine on clastogenic and genotoxic damage prevention caused by the administration of cisplatin. Forty Swiss mice were divided into 8 experimental groups: G1 and G2, which were control groups; G3, G4, and G5, which were administered [2 doses of glutamine (orally)] separated by a 24-h period (150, 300, and 600 mg/kg, respectively), and a dose of phosphate- ... more

J.R. Pesarini; S.G. Victorelli; A.P. Vicentini; L.K. Ferreira; M.O. Mauro; R. Matuo; J.R. Oliveira; A.C.M.B. Antoniolli; M.S. Mantovani; R.J. Oliveira
01/29/2014
AGE formation; Antioxidant; HMG-CoAR; Moringa oleifera; PPARα1; PPARγ

In Thai traditional medicine, Moringa oleifera is used for the treatment of diabetes and hyperlipidemia. Oxidative stress plays a major role in the pathogenesis of many degenerative diseases, such as hyperlipidemia, diabetes mellitus, and cardiovascular disease. We evaluated the antioxidant effect of M. oleifera extract (MOE) for reduction of advanced glycation end- ... more

W. Sangkitikomol; A. Rocejanasaroj; T. Tencomnao
01/10/2014
Antioxidant; CYP450; P-glycoprotein; Thunbergia laurifolia

Thunbergia laurifolia (TL) is widely used as an antidote in Thai traditional medicine against toxic substances such as alcohol, pesticides, arsenic, and strychnine. We found that the lyophilized form of TL in 80% ethanol possessed the antioxidant levels within the range 23,163.9 ± 1457.4 Trolox equivalents mM/kg dry mass and 899.8 ± 14.5 gallic acid equivalents mM/kg dry mass ... more

A. Rocejanasaroj; T. Tencomnao; W. Sangkitikomol
03/31/2006
Apis mellifera; Bioinformatics; doublesex gene; Evolution of genes; Molecular genetics; Sex determination; Sexual development; Transcription factors

A comparison of the most conserved sex-determining genes between the fruit fly, Drosophila melanogaster, and the honey bee, Apis mellifera, was performed with bioinformatics tools developed for computational molecular biology. An initial set of protein sequences already described in the fruit fly as participants of the sex-determining cascade was retrieved from the Gene ... more

A.S. Cristino; A.Mendes do Nascimento; Lda Fontour Costa; Z.Luz Paulin Simões
09/03/2013
Transcription factors; Transcriptome network; Unruptured intracranial aneurysms

Intracranial aneurysm is a balloon or sac-like dilatation of blood vessels inside the brain. Despite their importance, the biological mechanisms of intracranial aneurysms are not totally understood. We used public genome-wide gene expression profile data to identify potential genes that are involved in intracranial aneurysm in order to construct a regulation network. Some of the ... more

L. Wei; Y.J. Gao; S.P. Wei; Y.F. Zhang; W.F. Zhang; J.X. Jiang; Z.Y. Sun; W. Xu

Pages