Research Article

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10/19/2010
IL-6; Insulin resistance; SNP; TCF7L2; TNF; VDR

A population-based study was undertaken to evaluate linkage between single-nucleotide polymorphisms known as risk factors and type 2 diabetes in an Indian population. The study population was comprised of 40 normal glucose-tolerant individuals (21 males and 19 females) and 40 type 2 diabetes patients (21 males and 19 females). The genes and their corresponding single-nucleotide ... more

P.N. Mukhopadhyaya; A. Acharya; Y. Chavan; S.S. Purohit; A. Mutha
02/28/2013
Adipocytokines; Expression; Insulin resistance; Polycystic ovary syndrome; Subcutaneous adipose tissue

We reviewed emerging evidence linking serum levels and adipose tissue expression of leptin and adiponectin in women with polycystic ovary syndrome (PCOS). Previous data obtained by our group from a sample of overweight/obese PCOS women and a control sample of normal weight controls, both stratified by BMI, were reanalyzed. Circulating levels of leptin and adiponectin were determined by ... more

S.B. Lecke; D.M. Morsch; P.M. Spritzer
08/07/2014
Insulin resistance; Liver enzymes; Nonalcoholic fatty liver disease

Serum liver enzyme levels are often used effectively for the evaluation of nonalcoholic fatty liver disease (NAFLD). We aimed to investigate the associations between serum liver enzyme levels and risks for NAFLD in over 8000 cases in a large-scale analysis. A cross-sectional survey with multiple stages and random samplings was performed from May 2007 to May 2009 on 8102 workers at Tongji ... more

W.R. Bi; C.Q. Yang; Q. Shi; Y. Xu; C.P. Cao; J. Ling; X.Y. Wang
04/10/2015
Adiponectin; Insulin resistance; Nonalcoholic fatty liver disease; Tumor necrosis factor-a; Type 2 diabetes mellitus

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease caused by non-excessive alcohol consumption and is the most common cause of elevated levels of serum liver enzymes. We examined changes in adiponectin (APN) and tumor necrosis factor-α (TNF-α) in type 2 diabetes mellitus (T2DM) complicated by NAFLD and their relationships with insulin resistance (IR). Forty-two T2DM, 39 ... more

X. Lin; Z. Zhang; J.M. Chen; Y.Y. Xu; H.R. Ye; J. Cui; Y. Fang; Y. Jin; D.R. Zhu; L. Yuan
01/26/2015
Insulin resistance; Meta-analysis; Obesity; Polymorphism; TNF-α

Tumor necrosis factor-α (TNF-α) promoter polymorphisms has been reported to be associated with obesity and insulin resistance and gained widespread attention. However, results obtained so far are quite conf‍‍licting. We therefore performed a meta-analysis to address this issue, basing on 17 studies from electronic databases (MEDLINE and EMBASE). No evidence of ... more

H.G. Wang; J. Yang; H. Han; F. Xu; Y. Bian; H. Zhang; J.L. Wang
08/14/2015
Astragalus polysaccharide; Diabetes; Glucose and lipid metabolism; HPA axis; Streptozotocin

This study investigated the relationship between alterations in the hypothalamic-pituitary-adrenal (HPA) axis function and glucose and lipid metabolism in diabetic rats. To accomplish this a diabetes model was established by jointly administering a long-term high-fat diet plus Streptozotocin (STZ; 50 mg/kg ip). The rats were randomly divided into four groups: 1) a normal control group ... more

M.W. Si; M.K. Yang; X.D. Fu
12/21/2015
Apoptosis; Aquaporin; Cell proliferation; Diabetes; Myocardial cell

The aim of this study was to explore the effect of aquaporin on the molecular mechanism of human diabetic myocardial cell apoptosis. The methylthiazolyle tetrazolium assay was used to detect the inhibitory effect of different concentrations of aquaporin on cell growth. The rate of aquaporin-induced myocardial cell apoptosis was detected by flow cytometric analysis of Annexin V-fluorescein ... more

P.F. Zhao; M.J. Sun
10/28/2015
Alveolar bone cell; Bioinformatics; Biological pathway; Diabetes

Alveolar bone osteoblasts are widely used in dental and related research. They are easily affected by systemic diseases such as diabetes. However, the mechanism of diabetes-induced alveolar bone absorption remains unclear. This study systematically explored the changes in human alveolar bone cell-related gene expression and biological pathways, which may facilitate the investigation of ... more

X. Sun; Q.H. Ren; L. Bai; Q. Feng
10/16/2015
Diabetes; Human first trimester umbilical cord; Stem cell

Cells isolated from human first trimester umbilical cord perivascular layer (hFTM-PV) tissues display the pluripotent characteristics of stem cells. In this study, we examined whether hFTM-PV cells can differentiate into islet-like clusters (ILCs) in vitro, and whether transplantation of the hFTM-PV cells with and without differentiation in vitro can alleviate diabetes ... more

M. Cao; J.B. Zhang; D.D. Dong; Y. Mou; K. Li; J. Fang; Z.Y. Wang; C. Chen; J. Zhao; S.M. Yie
11/03/2016
Combined treatment; Diabetes; Inflammatory factors; Tear; Traditional Chinese medicine; Xerophthalmia

Diabetes-induced xerophthalmia is a general metabolic disorder with high incidence and increased treatment difficulty. Our study aimed to explore the combined effect of traditional Chinese and Western medicines on diabetes-associated xerophthalmia. We recruited 60 diabetic xerophthalmia patients, and randomly assigned them to either the control (Western medicine ... more

S.Q. Wu; Q. Dai; J.L. Xu; W.Y. Sheng; Q.B. Xu; L.Y. Zhong; S.Q. Wu; Q. Dai; J.L. Xu; W.Y. Sheng; Q.B. Xu; L.Y. Zhong; S.Q. Wu; Q. Dai; J.L. Xu; W.Y. Sheng; Q.B. Xu; L.Y. Zhong

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