Research Article

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07/28/2015
Methionine synthase reductase; Methylene tetrahydrofolate reductase; Recurrent miscarriages; Single nucleotide polymorphism

We aimed to explore the correlation between unexplained recurrent spontaneous abortion and polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes. A case control study was conducted in 118 patients with unexplained recurrent spontaneous abortion (abortion group) and 174 healthy women (control group). The genetic ... more

L. Zhu
07/14/2015
Database; EST; Evolution; Nicotiana; Primer; Single nucleotide polymorphism

Single nucleotide polymorphisms (SNPs) are widespread in the Nicotiana genome. Using an alignment and variation detection method, we developed 20,607,973 SNPs, based on the expressed sequence tag sequences of 10 Nicotiana species. The replacement rate was much higher than the transversion rate in the SNPs, and SNPs widely exist in the Nicotiana. In vitro ... more

Y. Wang; D. Zhou; S. Wang; L. Yang
12/29/2015
Alopecia areata; Association; Single nucleotide polymorphism; Transporter 1 ATP-binding cassette sub-family B

The transporter 1 ATP-binding cassette sub-family B (MDR/TAP) gene (TAP1) is located in the major histocompatibility complex class II region, and forms a heterodimer that plays a key role in endogenous antigen presentation pathways. Investigation of polymorphisms identified in these loci has revealed an association with several autoimmune disorders. Alopecia areata (AA) is a ... more

H.K. Kim; H. Lee; B.L. Lew; W.Y. Sim; Y.O. Kim; S.W. Lee; S. Lee; I.K. Cho; J.T. Kwon; H.J. Kim
12/28/2015
Asian pear; De novo assembly; differential gene expression; Pyrus pyrifolia; Simple sequence repeat; Single nucleotide polymorphism

This study investigated the Asian pear transcriptome using the RNA-Seq normalized fruit cDNA library to create a transcriptomic resource for unigene and marker discovery. Following the removal of lowquality reads, 127,085,054 trimmed reads were assembled de novo to yield 37,649 non-redundant unigenes with an average length of 599 bp. Alternative splicing events were detected in ... more

J.F. Li; Z. Gao; Y.S. Lou; M. Luo; S.R. Song; W.P. Xu; S.P. Wang; C.X. Zhang
12/21/2015
CTLA4; MECP2; PDCD1; Single nucleotide polymorphism; Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease that results in chronic inflammation of different organ systems. Several susceptibility loci for SLE have been suggested in different populations, but the nature of the susceptibility genes has yet to be determined. The programmed cell death 1 gene (PDCD1), the cytotoxic T-lymphocyte-associated protein 4 (CTLA4 ... more

H.R. Dong; H.S. Li; S.C. Wang; Q.M. Balin; P.Y. Chang
12/14/2015
Case-control study; COMT; Meta-analysis; Ovarian cancer; Single nucleotide polymorphism; Systematic review

The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ovid, EBSCO, PubMed, CNKI, CBMDISC, VIP, ... more

W. Pan; H. Liao
12/11/2015
Backfat thickness; Canchim cattle; Ribeye area; Single nucleotide polymorphism

Backfat thickness (BFT) and ribeye area (REA) are important production traits but, because they are measured late in the animal’s life, they have not been efficiently included in breeding programs. The aim of this study was to evaluate whether single nucleotide polymorphisms (SNPs) mapped to the leptin, PPARGC1A, PSMC1, CRH, and FABP4 genes, which ... more

G. Veneroni-Gouveia; P.C. Tizioto; S.L.C. Meirelles; A.C. Santiago; M.M. Alencar; L.C.A. Regitano
12/07/2015
Cloning; Expression profiles; Pig; Single nucleotide polymorphism; SLC13A5

Solute carrier family 13 (sodium-dependent citrate transporter member 5, SLC13A5) gene has been recently found to play an important role in intramuscular fat content in pigs. In this study, the full-length cDNA of porcine SLC13A5 was obtained from the longissimus dorsi muscle of Shaziling pigs, using the rapid amplification of cDNA ends technique. Full-length porcine ... more

L.Y. Wang; J. Jiang; H.M. Ma
12/01/2015
Hypertension; klotho gene; Single nucleotide polymorphism

The aim of this study was to examine the possible associations between the KLOTHO G-395A gene polymorphism and hypertension in Chinese nonagenarians and centenarians. The G-395A (rs1207568) in the promoter region of the KLOTHO gene was genotyped using a standard TaqMan allelic discrimination assay. We included 710 participants aged 93.5 ± 3.2 years in the analyses. The ... more

L.L. Gao; X. Ding; D.M. Xie; M. Yang; B.R. Dong
10/30/2015
Han Chinese population; Rheumatoid arthritis; Sequencing; Sialic acid acetylesterase; Single nucleotide polymorphism

The function of rare genotypes encoding defective variants of sialic acid acetylesterase (SIAE) in some autoimmune diseases, including rheumatoid arthritis (RA), is ambiguous. We determined whether mutations in the SIAE gene are responsible for RA in a Han Chinese population.DNA was prepared from the venous leukocytes of 444 RA patients and 647 normal controls. The coding regions ... more

D.D. Zhang; F. He; H.T. Liu; F. Hao; J. Zhu

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