Research Article

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Adipocyte; DNA methylation; MassArray; Pig; FASN

DNA methylation is a stable epigenetic mark mediating gene expression. Methylation is crucial for diverse biological processes, including aging and embryo development. FASN (fatty acid synthase) plays an important role in de novo lipogenesis, through catalyzing the reductive synthesis of long-chain fatty acids. In this study, we investigated the FASN gene ... more

K.R. Long; J.D. Ma; L. Chen; P.J. Wang; D.F. He; M.Z. Li; X.W. Li
DNA methylation; HPA; MDD; NR3C1

Major depressive disorder (MDD) has been associated with the stress response in the brain, which is controlled by the hypothalamic-pituitary-adrenal (HPA) axis. This HPA negative feedback mechanism acts via the activation of glucocorticoid receptor, which is encoded by the NR3C1 gene. The methylation status at the promoter of NR3C1 has been correlated with traumatic ... more

M. Nantharat; T. Wanitchanon; M. Amesbutr; R. Tammachote; V. Praphanphoj
DNA methylation; Epidermal growth factor receptor; Nom-small cell lung cancer

The aim of this study was to study the relationship of EGFR DNA methylation with the severity of non-small-cell lung cancer (NSCLC). We enrolled 54 patients with NSCLC between March 2013 and June 2014 from Department of Cardiothoracic Surgery in our hospital. The methylation levels in the promoter region of the EGFR gene in cancerous and pericarcinomatous tissue were ... more

J. Li; X.F. Jia; J. Liu; J.J. Liu; H.B. Zhao
DNA methylation; Glioma; Immunohistochemistry; SEMA3B

The aim of the current study was to explore mechanisms of SEMA3B gene expression and its clinical significance in glioma, and provide a theoretical foundation for investigating individualized treatment in glioma. Paraffin-embedded tissues from 43 patients with a confirmed clinical diagnosis of glioma following neurosurgery at the First Affiliated Hospital of Zhengzhou University from ... more

C.H. Pang; W. Du; J. Long; L.J. Song; C.H. Pang; W. Du; J. Long; L.J. Song; C.H. Pang; W. Du; J. Long; L.J. Song
Chromosomes, Plant; DNA methylation; DNA, Plant; Epigenesis, Genetic; Evolution, Molecular; Genetic variation; Genome, Plant; Microsatellite Repeats; Polyploidy; Random Amplified Polymorphic DNA Technique; Triticum

We used the conventional and methylation-sensitive randomly amplified polymorphic DNA (RAPD) and inter-simple sequence repeat (ISSR) analyses to assess genome-wide changes and explore the relationships between genetic and epigenetic variations among individuals of a newly synthesized allohexaploid wheat line whose genomic constitution is identical to that of the natural common wheat, compared ... more

T. Qiu; Y.Z. Dong; X.M. Yu; N. Zhao; Y.F. Yang
DNA methylation; Nucleic Acid Amplification Techniques; Polymorphism, Genetic; Saccharum

Micropropagation is an important tool for large-scale multiplication of plant superior genotypes. However, somaclonal variation is one of the drawbacks of this process. Changes in DNA methylation have been widely reported as one of the main causes of somaclonal variations in plants. In order to investigate the occurrence of changes in the methylation pattern of sugarcane somaclonal variants, ... more

J.H.M.B. Francischini; E.L. Kemper; J.B. Costa; J.R.V. Manechini; L.R. Pinto
2017 Jun 29
Animals; CpG islands; DNA methylation; fucosyltransferases; Galactoside 2-alpha-L-fucosyltransferase; Glycosphingolipids; Promoter Regions, Genetic; Swine; Transcriptional activation

Glycosphingolipid biosynthesis-globo series pathway genes (FUT1, FUT2, ST3GAL1, HEXA, HEXB, B3GALNT1, and NAGA) play an important regulatory role in the defense against Escherichia coli F18 in piglets. In this study, we identified the transcription initiation site and promoter of this gene cluster by mined previous RNA-seq results using bioinformatics tools. The FUT1 transcription initiation ... more

W.Y. Qin; L.N. Gan; R.W. Xia; W.H. Dong; S.Y. Sun; G.Q. Zhu; S.L. Wu; W.B. Bao
Chromosomes, Plant; DNA methylation; Genome, Plant; Genome-wide association study; Gossypium; Salinity; Stress, Physiological

Cytosine DNA methylation is a significant form of DNA modification closely associated with gene expression in eukaryotes, fungi, animals, and plants. Although the reference genomes of cotton (Gossypium hirsutum L.) have been publically available, the salinity-stress-induced DNA methylome alterations in cotton are not well understood. Here, we constructed a map of genome-wide DNA methylation ... more

X.K. Lu; N. Shu; J.J. Wang; X.G. Chen; D.L. Wang; S. Wang; W.L. Fan; X.N. Guo; L.X. Guo; W.W. Ye
Biomarkers; Colorectal cancer; DKK2 gene; DNA methylation; Epigenetics
Purpose: Epigenetic changes can be detected in precancerous lesions, suggesting that may be involved in the early stages of carcinogenesis. The methylation of specifics genes has been correlated with the outcome of many different types of cancers. This study compared the levels of DNA methylation between normal and tumor tissues from patients with colorectal ... more
T.D. Silva; A.V. Felipe; V.M. Vidigal; S.S. Saad; N.M. Forones
DNA methylation; Epigenomics; Hepatoblastoma; OCIA domain containing; Oncology

Hepatoblastoma (HB) is the most common malignant liver tumor in children; however, the molecular mechanisms responsible for its progression remain unclear. We previously identified hypermethylation of the ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) as a poor prognostic factor for HB in a genome-wide methylation analysis of HB ... more

M. Minato; S. Honda; H. Miyagi; A. Taketomi