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Bayesian bootstrap; Bioinformatics; Gene expression; Microarray; Statistics; Web tool

One of the goals of gene expression experiments is the identification of differentially expressed genes among populations that could be used as markers. For this purpose, we implemented a model-free Bayesian approach in a user-friendly and freely available web-based tool called BayBoots. In spite of a common misunderstanding that Bayesian and model-free approaches are incompatible, ... more

R.Z.N. Vêncio; D.F.C. Patrão; C.S. Baptista; C.A.B. Pereira; B. Zingales
Field trial; Monte Carlo simulation; Plant breeding; Plot size; Statistics

We aimed to establish standards for tobacco Valor de Cultivo e Uso (VCU) in Brazil. We obtained information regarding the size and design of plots of two varietal groups of tobacco (Virginia and Burley). Ten inbred lines of each varietal group were evaluated in a randomized complete block design with four replications. The plot contained 42 plants with six rows of seven columns each. For ... more

F.H.R.B. Toledo; M.A.P. Ramalho; C.E. Pulcinelli; A.T. Bruzi
Artificial Intelligence; Discrimination; Similarity; Statistics

The correct classification of individuals is extremely important for the preservation of genetic variability and for maximization of yield in breeding programs using phenotypic traits and genetic markers. The Fisher and Anderson discriminant functions are commonly used multivariate statistical techniques for these situations, which allow for the allocation of an initially unknown ... more

I.C. Sant’Anna; R.S. Tomaz; G.N. Silva; M. Nascimento; L.L. Bhering; C.D. Cruz
Carcinoma; Factor analysis; Pancreatic duct; Prognosis; Statistics; Transcription factor

The aim of this study was to explore the correlation between the expression levels of Gli1 and p53 in pancreatic ductal adenocarcinoma (PDAC) and its pathological significance. Immunohistochemistry (IHC) was employed to measure the expression level of Gli1 and p53 in 85 sets of paraffin-embedded PDAC and corresponding para-carcinoma tissue specimens. The relationship between these results ... more

Y. Abula; C. Yi; X.Y. Wang; M. Wang; R.Y. Qin; Y.Q. Guo; H. Lin; H.J. Li
Idiopathic azoospermia; Idiopathic oligospermia; Pygo2 gene; SNPs

Male infertility is often associated with a decreased sperm count. The Pygo2 gene is expressed in the elongating spermatid during chromatin remodeling; thus impairment in PYGO2 function might lead to spermatogenic arrest, sperm count reduction, and subsequent infertility. The aim of this study was to identify mutations in Pygo2 that might lead to idiopathic oligospermia ... more

S.Q. Ge; J. Grifin; L.H. Liu; K.I. Aston; L. Simon; T.G. Jenkins; B.R. Emery; D.T. Carrell
Body size; Haplotype; IGFBP-6; Mini-pig; SNPs

Insulin-like growth factor binding protein-6 (IGFBP-6) is a member of the IGFBP family, which is known to be a key factor in regulating the effect of insulin-like growth factor-2 (IGF-2) on the animal growth and development. Gene sequences of 3'-untranslated regions (UTR) and exon 4 of IGFBP-6 may influence the expression and proteolysis of IGFBP-6. In this study, 551 bp of the ... more

X.B. Fang; S.C. Liu; Q.Y. Wu; S.M. Li; Y.Y. Cheng; H.Y. Fu; C. Lu; D. Su; H. Yu; L.L. Hao
APM1; Disorders of lipid metabolism; HDCP; SNPs

The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) in APM1 contribute to disorders of lipid metabolism in hypertensive disorder complicating pregnancy (HDCP). The study included 178 pregnant women with HDCP and 243 healthy pregnant controls. Using PCR-restriction fragment length polymorphism, we detected the frequencies of genotypes, alleles, ... more

Y. Wang; R.X. Liu; H. Liu
Genetic diversity; Haplo-block structure; SNPs; Village chickens

This study investigated the haplo-block structure, haplotype sharing, and diversity in extensively raised chicken populations of Southern Africa. Two hundred ninety village chickens from Malawi (N = 30), South Africa (N = 132), and Zimbabwe (N = 128) were included in the study, from which 649, 2104, and 2442 haplo-blocks were observed, respectively. The majority of haplo-blocks were ... more

K.S. Khanyile; E.F. Dzomba; F.C. Muchadeyi
Duck; Fatty acid composition; SCD1; Serum biochemical levels; SNPs

Stearoyl-coenzyme A desaturase 1 (SCD1) is the key limiting enzyme in the synthesis of monounsaturated fatty acids, and plays a crucial role in the regulation of oleic acid. In this study, 165 ten-week-old Cherry Valley ducks were used to investigate single nucleotide polymorphisms (SNPs) in the 5' regulatory region of the SCD1 gene, and their associations with duck serum ... more

W.G. Li; Y.Y. Zhang; D.D. Wang; W.G. Li; Y.Y. Zhang; D.D. Wang
IFIH1; Meta-analysis; SLE; SLE clinical manifestations; SNPs

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder presenting heterogeneous clinical manifestations. A number of genes involved in SLE susceptibility are related to the type I interferon (IFN) pathway. IFN mediates innate immune responses and its increased levels contribute to the breakdown of peripheral tolerance. Interferon-induced helicase C ... more

deAzevêdo Silva; S.C. Lima; C. Addobbati; R. Moura; L.A.Cavalcanti Brandão; J.A.Trés Pancoto; E.A. Donadi; S. Crovella; P. Sandrin-Garcia