Research Article

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11/30/2019
Genetic polymorphism; HIV; Interleukin-7 receptor; Limpopo Province; Opportunistic Infections; Single nucleotide polymorphism

Genetic polymorphism of cytokine genes has been shown to be associated with susceptibility to diseases. We investigated the frequency of the IL-7 receptor-α +510 CT SNP in relation to pain and other symptoms among HIV and AIDS patients attended at various South African hospitals for treatment. Demographic as well as clinical data was obtained through structured ... more

T.C. Nangammbi; G.T. Moloro; A. Samie
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Dyslipidemia; Genetic polymorphism; LDL-cholesterol

The main polymorphisms linked to dyslipidemia include those of the SMARCA4 gene. We evaluated the association between lipidic profile and SMARCA4 gene polymorphism in 200 military police officers. Real time PCR was used to identify SMARCA4 gene polymorphisms. Among the subjects, 116 had dyslipidemia (case group), of which 94% were males, ... more

H.A.G.B. Queiroz; F.S. Castro; A.M.T.C. Silva; C.M. Gomes; S.H.N. Costa; L.C. da Cunha
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CD1 antigen presenting molecules; Colorectal cancer; Genetic polymorphism; Saudi Arabia

Cluster of differentiation 1 (CD1) is antigen-presenting molecule involved in the presentation of lipid and glycolipid antigens to specific T cells and natural killer T cells. They exhibit a low rate of polymorphism compared to classical major histocompatibility complex presenting molecules. In this case control study, we examined a possible association of genetic ... more

S. Alomar; J. Al-Tamimi; T. Almanaa; A. Al-jurayyan; L. Mansour
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Chronic diseases; Genetic polymorphism; Interleukin; Periodontitis

Chronic periodontal disease (CPD) is described as a recurrent inflammatory condition of tooth supporting tissues, caused by bacterial infections and self-destructive processes of immune activity mediated by pro-inflammatory cytokines, of which the interleukins 1β, 6 and 8 stand out; together with other biomolecules these cytokines mediate innate immunity. These ... more

J.A.X. Manso; R. Hannum; J.S. Fortes; S.S.M. Duarte; A.S. da Cruz; L.B. Minasi; A.D. da Cruz; C.C. da Silva
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Coronavirus; COVID-19; Diabetes mellitus; Genetic polymorphism; SARS-CoV-2

Diabetic patients have shown greater vulnerability, significant mortality, and serious complications when infected with SARS-CoV-2. Interindividual variation in susceptibility to severe progression of COVID-19 in diabetic patients has been associated with genetic polymorphisms. This systematic review protocol will critically synthesize the scientific evidence on ... more

L.C. Silveira; K.F. Santos; J.S. Campos; R.S. Santos; A.A.S. Reis
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Diagnosis; Enzyme-linked immunospot; Meta-analysis; Tuberculous pleurisy

Current methods for diagnosing tuberculous pleurisy are poor. Some studies have explored the diagnostic value of a pleural effusion enzyme-linked immunospot (ELISPOT) assay, but its accuracy remains controversial. Therefore, we performed a meta-analysis of the existing evidence on the ability of the ELISPOT assay to diagnose tuberculous pleurisy. We systematically searched PubMed, Google ... more

Z.Z. Li; W.Z. Qin; L. Li; Q. Wu; Y.J. Wang
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Chronic obstructive pulmonary disease; Gene polymorphism; Meta-analysis; Vitamin D-binding protein

Gene polymorphism of vitamin D-binding protein (VDBP) correlates with chronic obstructive pulmonary disease (COPD), but the results remain inconclusive. We aimed to explore the association between VDBP gene polymorphism and COPD. We searched MEDLINE, Embase, Web of Science, and China National Knowledge Infrastructure for publications addressing the association between VDBP gene ... more

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COL1A1; Gene polymorphism; Meta-analysis; Osteoporosis

Studies investigating the association between the COL1A1 gene -1997G/T polymorphism and the risk of osteoporosis in postmenopausal women have reported conflicting results. We performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship. We conducted searches of the published literature in the ... more

K.H. Yu; J. Tang; C.Q. Dai; Y. Yu; J.J. Hong
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Cervical carcinoma; Gene polymorphism; Meta-analysis; XRCC1

Numerous studies have evaluated the association between Arg399Gln polymorphism of DNA repair gene XRCC1 and cervical carcinoma risk. However, the specific association is still controversial. To assess the relationship between XRCC1 Arg399Gln polymorphism and cervical carcinoma, we conducted a comprehensive meta-analysis of 10 case-control studies with 2051 cervical carcinoma cases and ... more

D.Y. Liu; H.C. Liang; X.M. Xiao
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Interleukin 21; Meta-analysis; Polymorphism; Systemic lupus erythematosus

Several case-control studies have been conducted to investigate the association between Interleukin-21 (IL-21) polymorphisms and systemic lupus erythematosus (SLE) susceptibility, and most of the studies focused on IL-21 rs907715 and rs2221903 polymorphisms. Given the inconsistent results from these studies, the present meta-analysis aimed to obtain a more precise estimate of the ... more

J.H. Qi; J. Qi; L.N. Xiang; G. Nie

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