Research Article

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Diabetes mellitus; experimental; MicroRNA profiling; Skin; Wound healing

Despite years of effort, current therapies for diabetic wounds are still not fully efficacious. Emerging evidence has suggested that microRNAs (miRNAs) play key roles in multiple physiological and pathological processes in eukaryotes, and could potentially be powerful therapeutic tools. This study investigated the differential expression profiling of miRNAs in cutaneous wounds in ... more

Y.F. Liu; M. Ding; D.W. Liu; Y. Liu; Y.G. Mao; Y. Peng
ABCG5; Cholesterol efflux; CYP7A1; Diabetes mellitus; LXRβ; Monocyte macrophage

The purpose of this study was to examine the changes of cellular cholesterol efflux from macrophages in patients with type II diabetes mellitus (DM), and to determine the expression of CYP7A1, ABCG5, and LXRβ therein. We recruited 30 patients with type II DM (including 15 patients complicated with coronary heart disease and 15 patients with DM only) and 15 normal controls for this study ... more

L.D. Bao; C.Q. Li; R. Peng; X.H. Ren; R.L. Ma; Y. Wang; H.J. Lv
Antibodies; Diabetes mellitus; HLA

To differentiate among different types of diabetes is becoming an increasingly challenging task. We investigated whether the patient’s genetic profile is useful to identify the particular type of diabetes, to determine the corresponding hyperglycemia pathogenesis and treat accordingly. Three hundred and thirty-eight diabetic patients, diagnosed according to American Diabetes Association ... more

A. Mimbacas; L. García; P. Zorrilla; M. Acosta; C. Airaudo; R. Ferrero; A. Pena; B. Simonelli; E. Soto; G. Vitarella; J. Fernandez; G. Javiel
COX; Diabetes mellitus; MMP-9; NF-κB; Resveratrol; SIRT1

Resveratrol (RSV) has a beneficial role in the prevention of diabetes and alleviates some diabetic complications, such as cardiomyopathy. We investigated cyclooxygenase-1 (COX-1), COX-2, nuclear factor κB (NF-κB), matrix metalloproteinase-9 (MMP-9), and sirtuin 1 (SIRT1) mRNA expression levels in heart tissue after RSV treatment in streptozotocin (STZ)-induced diabetic rats. After ... more

A.S. Yar; S. Menevse; E. Alp
Coronary artery disease; Cox-2 (-765G > C); Diabetes mellitus; IL-6; Polymorphism

Coronary artery disease is one of the leading causes of mortality and diabetes mellitus is one of its main risk factors due to microvascular and macrovascular complications, such as atherosclerosis. Atherosclerosis is now known to be an inflammatory process mediated by prostaglandins and several interleukins. As both are important in inflammatory processes, we examined Cox-2 (-765G > C ... more

K.K. Ol; B. Agachan; U. Gormus; B. Toptas; T. Isbir
Diabetes mellitus; Hypertension; Polymorphism; RT-qPCR; VDR gene

RT-qPCR was used to analyze the vitamin D receptor (VDR) gene TaqI polymorphism in 100 Turkish patients with type 2 diabetes mellitus (T2DM) and hypertension compared with 100 healthy subjects, to determine whether VDR could be considered as one of the susceptibility genes for T2DM and hypertension. Genotyping was done with PCR, followed by melting curve analysis with specific fluorescent ... more

H.C. Vural; E. Maltas
Diabetes mellitus; Diabetic gastroparesis; Endothelin; Gastric evacuation rate; Irbesartan; Leptin

Diabetic gastroparesis (DG) is a common clinical complication of diabetes mellitus. Leptin may cause delayed gastric emptying in the central and peripheral pathways. Microcirculatory disturbances in the stomach make gastric smooth muscles and nerves hypoxic-ischemic, thereby impairing gastric motility. Irbesartan is an angiotensin II (ATII) receptor blocker that indirectly decreases serum ... more

L. He; Y. Sun; Y. Zhu; R. Ren; Y. Zhang; F. Wang
Diabetes mellitus; Glycosylated hemoglobin; Hospital-related hyperglycemia; Hyperglycemia

Hyperglycemia is common in critical patients and high blood glucose levels have a negative effect on their prognosis. The aim of this study was to investigate the effect of hyperglycemia and glycosylated hemoglobin (GHb) in critical patients. A total of 648 critical patients were enrolled in the study and received a random blood glucose test when they entered the emergency department. If ... more

Z.L. Zhang; X.M. Che; Z.H. Bai; W.J. Bu; L. Bai; H.H. Pei
Diabetes mellitus; Genetic polymorphisms; HNF1β; Meta-analysis; Prostate cancer

Polymorphism 17q12 rs4430796 within HNF1βis a genetic variant associated with both diabetes mellitus and prostate cancer, but findings on the correlations of rs4430796 with prostate cancer risk specifically are not in agreement, especially among diverse populations. To shed some light on the contradictory findings, therefore, we carried out a meta-analysis by pooling the ... more

Y.Z. Xiang; S.B. Jiang; J. Zhao; H. Xiong; Z.L. Cui; G.B. Li; X.B. Jin
Atherosclerosis; Diabetes mellitus; Diabetic foot; High mobility group box 1; Peripheral arterial occlusive disease

The role of high mobility group box 1 (HMGB1) has been demonstrated in stroke and coronary artery disease but not in peripheral arterial occlusive disease (PAOD). The pathogenesis of HMGB1 in acute and chronic vascular injury is also not well understood. We hypothesized that HMGB1 induces inflammatory markers in diabetic PAOD patients. We studied 36 diabetic patients, including 29 ... more

C.F. Tsao; W.T. Huang; T.T. Liu; P.W. Wang; C.W. Liou; T.K. Lin; C.J. Hsieh; S.W. Weng