Research Article

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Propofol is a commonly used intravenous anesthetic. We evaluated its effects on the behavior of human pancreatic cancer cells and the underlying molecular mechanisms. The effects of propofol on Panc-1 cell proliferation, apoptosis, and invasion were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, caspase-3 activity measurement, and Matrigel invasion ... more

Z.T. Wang; H.Y. Gong; F. Zheng; D.J. Liu; T.L. Dong
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Burn; Propofol; Remifentanil; Target-control infusion

This study evaluated the feasibility and effectiveness of using the bispectral index (BIS) to monitor anesthetic depth in patients with severe burns receiving intravenous target-controlled infusion (TCI) of remifentanil and propofol. We randomly assigned 80 patients undergoing elective escharectomy (<1 week) to BIS (A) and control (B) groups. All patients received remifentanil and propofol ... more

Z.G. Guo; X.P. Jia; X.Y. Wang; P. Li; X.J. Su; J.H. Hao
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Invasion; MiR-874; Osteosarcoma; Prognosis; Proliferation

Dysregulation of microRNAs (miRs) is associated with cancer development and progression and aberrant expression of miR-874 have been found in some types of cancer. However, the expression and function of miR-874 in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-874 in osteosarcoma tumorigenesis and development. The expression level of miR-874 was ... more

L.Q. Zhang; S.L. Sun; W.Y. Li; Z. Feng; X.Y. Xu; Q.S. Zhuang; J. Fang
11/13/2015
Invasion; miR-184; Osteosarcoma; Proliferation

Osteosarcoma is a highly malignant cancer that often appears in teenagers. It is the most frequently occurring primary bone tumor, and can easily metastasize, resulting in high mortality. MicroRNAs express abnormally in osteosarcoma, and may function as oncogenes or tumor suppressors. Recent studies showed that microRNA184 (miR-184) is abnormally expressed in multiple tumors, and is ... more

G.R. Yin; Q. Wang; X.B. Zhang; S.J. Wang
01/24/2014
Adult; Emergence agitation; Isoflurane; Propofol

Distal radius fracture is a common wound. It is reduced by surgery under anesthesia. Emergence agitation can often occur after anesthesia. It is associated with increased morbidity and hospital costs. However, there have been almost no reports in the medical literature on the occurrence of emergence agitation in adults. This study aimed to compare emergence agitation between isoflurane ... more

G.Y. Liu; Z.Q. Chen; Z.W. Zhang
02/13/2014
General anesthesia; Opioid analgesic; Palinesthesia; Post-surgery; Propofol; Remifentanil

When recovering from general anesthesia, upon removal of the endotracheal tube, patients may experience a high dynamic response in the circulatory system, along with choking and restlessness. This study was designed to study the effect of maintaining an intravenous infusion of remifentanil or propofol on the performance of general anesthesia, including on the cardiovascular response, ... more

X. Zhao; Y.W. Jin; H.B. Li; Z.G. Wang; H. Feng; C. Feng
05/11/2015
Etomidate; Glucocorticoid receptor; Propofol; Sepsis

The aim of this study was to determine the effect of etomidate and propofol pretreatment on the expression of glucocorticoid receptor and the prognosis of sepsis. The sepsis rat was used as a model. During glucocorticoid treatment, etomidate and propofol were applied alone or together at different time points. Survival curves, glucocorticoid receptor expression in the rat adrenal cortex, ... more

C. Wang; N. Liu; R.M. Li; Y. Zhang; L. Shen; J.Y. Xiong
04/17/2015
Children; Fentanyl; Intrathecal injection; Propofol

This study explored the sedative and analgesic effects of fentanyl combined with propofol via an intrathecal chemotherapy injection for acute leukemia (acute lymphocytic leukemia or acute myelocytic leukemia) among children, to relieve pain and difficulty during intrathecal injection, improve treatment compliance, increase the success rate of single puncture, and reduce procedure failure ... more

X. Tian; Y.H. Yang; H.Y. Wei; J.Q. Lao; H.P. Wang; Y.Y. Tian
11/23/2015
Apoptosis; Cell proliferation; Checkpoint kinase 1; Gamma-aminobutyric acid type A receptor; p53; Propofol

We investigated the effect of propofol on the proliferation and viability of rat embryonic neural stem cells (rENSCs) and the potential mechanisms involved. rENSCs were isolated and cultured in vitro and treated with 1, 10, or 50 μM propofol, while the control group was treated with 0.1 μM dimethyl sulfoxide. The effect of propofol on the proliferation and viability of rENSCs was ... more

J.W. Wang; W.W. Cheng; T. Xu; Z.Y. Yang
04/04/2016
Apoptosis; Gastric cancer; miR-451; MMP-2; Proliferation; Propofol

Propofol is an extensively used intravenous anesthetic agent. The aim of the present study was to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms associated with this activity. The effects of propofol on proliferation and apoptosis in the SGC-7901 gastric cancer cell line were detected by an MTT assay and measurement of caspase-3 ... more

Z. Peng; Y. Zhang; Z. Peng; Y. Zhang; Z. Peng; Y. Zhang

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