Research Article

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12/17/2015
CYP1B1; Meta-analysis; Primary open-angle glaucoma; SNP

Mutations in the CYP1B1 gene were detected in primary open-angle glaucoma (POAG) patients. However, the association between these mutations and the incidence of POAG remains to be elucidated. Here, we have conducted a meta-analysis to analyze this correlation, using relevant studies obtained from an extensive search of various electronic databases, including EMBase, Web of ... more

Z. Wang; M. Li; L. Li; H. Sun; X.Y. Lin
12/02/2015
Hepatocellular carcinoma; HLA-DP; Meta-analysis; SNP

The association between the HLA-DP single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 and hepatocellular carcinoma (HCC) has been reported, but results have been inconclusive and controversial. Therefore, to investigate the relationship between these HLA-DP SNPs and HCC susceptibility, a meta-analysis of studies published before January 2014 was carried out ... more

X. Zhang; C. Zheng; Z.H. Zhou; M. Li; Y.T. Gao; S.G. Jin; X.H. Sun; Y.Q. Gao
04/25/2016
COPD; MMP-1; MMP-3; MMP-9; rs1799750; rs3918242

Correlations between genetic polymorphisms of three matrix metalloproteinase (MMP) genes and susceptibility to chronic obstructive pulmonary disease (COPD) were investigated. Relevant case-control studies were selected using rigorous inclusion and exclusion criteria. The comprehensive Meta-analysis 2.0 software was used to conduct the statistical analysis. An odds ratio with 95% ... more

S. Jiang; Z.H. Yang; Y.Y. Chen; Z. He; Y. Zhou; Y. Gao; Q. Zhang; M.Q. Tan; S. Jiang; Z.H. Yang; Y.Y. Chen; Z. He; Y. Zhou; Y. Gao; Q. Zhang; M.Q. Tan; S. Jiang; Z.H. Yang; Y.Y. Chen; Z. He; Y. Zhou; Y. Gao; Q. Zhang; M.Q. Tan
09/22/2015
Body measurement traits; Carcass quality traits; SNP; STAT3

Previous studies have shown that the signal transducer and activator of transcription 3 gene (STAT3) is involved in lipid storage and energy metabolism, suggesting that STAT3 is a potential candidate gene that affects body measurement and carcass quality traits in animals. Therefore, the aim of this study was to identify polymorphisms in bovine STAT3 and to ... more

N. Song; L.S. Gui; H.C. Xu; S. Wu; L.S. Zan
09/08/2015
CRH; Economic traits; Hanwoo; Korean cattle; POMC; SNP

The corticotrophin-releasing hormone (CRH) and proo­piomelanocortin (POMC) genes are considered to play an important role in the growth and development of mammals. In this study, the bovine CRH and POMC genes were characterized to detect genetic variation at these loci in relation to economic traits in Korean cattle (Hanwoo). Nine single ... more

J. Seong; H.S. Kong
08/14/2015
Association study; Schizophrenia; SNP; VRK2 gene

Previous studies have found that the vaccinia related kinase 2 gene (VRK2) polymorphism was associated with schizophrenia (SCZ) in the worldwide population. This association was further supported by VRK2 mRNA expression patterns and brain structure variations. Here, we analyzed four single nucleotide polymorphisms (SNPs) of the VRK2 gene in a total population of 893 ... more

B. Zhang; C.Y. Gao; H.B. Zhang; B. Yang; J.F. Yin; S.G. Wei; Y.S. Zhu; X.N. Jia; S.B. Li
12/21/2015
Hu sheep; Maternal behavior; PRLR gene; SNP

The prolactin receptor gene (PRLR) plays an essential role in maternal behavior. The aim of the study was to detect PRLR mutations in exon 10, using a polymerase chain reaction-single stranded conformation polymorphism method, and to determine the association between mutations in this region with maternal behavior traits in Chinese Hu sheep. Polymorphisms were detected ... more

L.P. Wang; R.Q. Geng; X.N. Zhang; W. Sun
12/22/2015
Expression profile; GAS6; Immunohistochemistry; Pig; SNP

The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. A recent report has demonstrated that the GAS6 gene can promote fat deposition and is associated with an increased number of fat cells in mice. In order to investigate ... more

D. Xu; J. Jiang; J. He; C.Q. He; H.M. Ma
12/21/2015
Age-related macular degeneration; Atrophic macular degeneration; Genome-wide association study; Oldest old; SNP

The aim of this study was to identify disease-associated loci in oldest old Han Chinese with atrophic age-related macular degeneration (AMD). This genome-wide association study (GWAS) only included oldest old (≥95 years old) subjects in Rugao County, China. Thirty atrophic AMD patients and 47 age-matched non-AMD controls were enrolled. The study subjects underwent a complete ophthalmic ... more

T.Q. Zhou; H.J. Guan; J.Y. Hu
12/02/2015
Genome-wide association study; Meat pH; SNP; Swine

Meat pH is an important factor influencing meat quality traits in swine. This study evaluated a large number of genetic variants that covered all of the swine chromosomal regions. Approximately 68,000 single nucleotide polymorphisms (SNPs), found on Illumina Porcine SNP chips, were tested for associations with meat pH values. A genome-wide association study (GWAS) found that 19 SNPs on ... more

H.Y. Chung; K.T. Lee; G.W. Jang; J.G. Choi; J.G. Hong; T.H. Kim

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