Research Article

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12/29/2015
Meta-analysis; Polymorphism; Prostate cancer

Recent studies have indicated that single nucleotide polymorphisms (SNPs) within the 8q24 region may be a risk factor for prostate cancer (PCa). Here, we performed a meta-analysis to evaluate the association between the 8q24 rs6983267 T/G polymorphism and PCa risk. A systematic literature search was carried out in multiple electronic databases independently by two investigators. Pooled ... more

H.S. Zhu; J.F. Zhang; J.D. Zhou; M.J. Zhang; H.X. Hu
12/29/2015
Cardiopulmonary bypass; Interleukin-6; Interleukin-8; Meta-analysis; Sevoflurane

This study aimed to investigate the effect of sevoflurane on serum levels of interleukin (IL)-6 and IL-8 in patients who underwent cardiopulmonary bypass (CPB). The strength of the association between sevoflurane treatment and serum level of IL-6 and IL-8 was determined in patients who underwent CPB by summary standard mean differences (SMDs); 95% confidence interval (CI) was used. In ... more

Q.B. Yu; H.M. Li; L.L. Li; S.Y. Wang; Y.B. Wu
12/29/2015
Interleukin-10; Meta-analysis; Nasopharyngeal carcinoma; Polymorphism; Promoter genes

It has been reported that interleukin-10 (IL-10) promoter genes (1082 A/G, 819 T/C, 592 A/C) are associated with nasopharyngeal carcinoma (NPC). However, the results remain controversial and ambiguous. To resolve inconsistencies in published data, we performed a meta-analysis to ascertain the association between IL-10 polymorphisms and NPC risk. Two case-control studies and two cohort ... more

Y.F. Yu; Z.G. Han; W.B. Guo; G.J. Zhang; J.K. Yang; F.L. Wu; Q.Y. Ou; Y.H. Li; X.Y. Cai; Z.N. Zhan; J.H. Chen; W.L. Xie; L. Tang; C.D. Liu
12/29/2015
GSTM1; GSTT1; Meta-analysis; Polymorphism; Varicocele

The glutathione S-transferase (GST) family represents a major group of detoxification and antioxidant enzymes. Studies have shown that high oxidative stress levels are associated with varicocele. The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patients and 476 ... more

B. Zhu; L. Yin; J.Y. Zhang
12/29/2015
Cardiovascular disease; Coronary artery disease; Gene; Meta-analysis; Polymorphism; PPARγ2

This meta-analysis investigated the correlation between the PPARγ2 Pro12Ala polymorphism and cardiovascular disease (CVD). Electronic database and manual searches were conducted to retrieve studies published relevant to the PPARγ2 Pro12Ala polymorphism and CVD. Rigorous inclusion and exclusion criteria were employed for selection of ... more

Y. Li; J. Zhu; J.Q. Ding
12/28/2015
Alcohol dehydrogenase 2; Coronary artery disease; Meta-analysis; Polymorphism

We studied the association between aldehyde dehydrogenase 2 (ALDH2) polymorphism and coronary artery disease (CAD) and clarified the mechanisms underlying this association. We searched the ISI, Medline (Ovid), PubMed, CNKI, Wanfang, and Weipu Databases. Statistical analysis was performed using Revman 5.0 and Stata12.0 softwares. A total of 3305 cases and 5016 controls in 12 case-control ... more

L.L. Zhang; Y.Q. Wang; B. Fu; S.L. Zhao; Y. Kui
12/22/2015
Biomarker; Colorectal cancer; Diagnostic marker; Meta-analysis; MicroRNA-29a

Previous studies have revealed that the expression level of microRNA-29a (miR-29a) was remarkably different in colorectal cancer (CRC) patients and healthy controls, indicating that miR-29a can be used as a diagnostic marker of CRC, but the results have been inconsistent. We conducted this meta-analysis to assess the diagnostic performance of blood-based miR-29a for CRC. We performed a ... more

M.L. Zhi; Z.J. Liu; X.Y. Yi; L.J. Zhang; Y.X. Bao
12/22/2015
AGER; Breast cancer; Lung cancer; Meta-analysis; Polymorphisms

We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), and China National ... more

N.C. Yin; X.P. Lang; X.D. Wang; W. Liu
12/17/2015
Meta-analysis; Polymorphism; Tumor necrosis factor-α; Vitiligo

Several case-control studies have been conducted to investigate the association between the tumor necrosis factor-α (TNF-α)-308G/A polymorphism and vitiligo risk. However, the results of these studies are inconsistent; therefore, we attempted to comprehensively evaluate the association between TNF-α-308G/A polymorphism and vitiligo risk via a meta-analysis. Studies reporting the ... more

G. Nie; J.H. Qi; C.W. Huang; T. Yang; N. Shi; Y.J. Chen
12/17/2015
CYP1B1; Meta-analysis; Primary open-angle glaucoma; SNP

Mutations in the CYP1B1 gene were detected in primary open-angle glaucoma (POAG) patients. However, the association between these mutations and the incidence of POAG remains to be elucidated. Here, we have conducted a meta-analysis to analyze this correlation, using relevant studies obtained from an extensive search of various electronic databases, including EMBase, Web of ... more

Z. Wang; M. Li; L. Li; H. Sun; X.Y. Lin

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