Research Article

Related GMR Articles

Genetic polymorphism; Matrix metalloproteinase-3; mRNA expression; Rheumatoid arthritis

Matrix metalloproteinase-3 (MMP-3) can mediate the occurrence and development of rheumatoid arthritis (RA). The MMP3 promoter gene exhibits polymorphism with 5A/6A alleles. We investigated the correlation between the expression of MMP3 gene polymorphism and RA to provide an objective basis for prognosis evaluation. We enrolled 80 RA patients and 80 healthy subjects. Enzyme- ... more

M.J. Ma; H.C. Liu; X.Q. Qu; J.L. Wang
Han Chinese population; Rheumatoid arthritis; Sequencing; Sialic acid acetylesterase; Single nucleotide polymorphism

The function of rare genotypes encoding defective variants of sialic acid acetylesterase (SIAE) in some autoimmune diseases, including rheumatoid arthritis (RA), is ambiguous. We determined whether mutations in the SIAE gene are responsible for RA in a Han Chinese population.DNA was prepared from the venous leukocytes of 444 RA patients and 647 normal controls. The coding regions ... more

D.D. Zhang; F. He; H.T. Liu; F. Hao; J. Zhu
Fibroblast-like synoviocytes; Myeloid differentiation factor 88; Rheumatoid arthritis; Sinomenine; Tumor necrosis factor receptor associated factor-6

The effect of sinomenine (SIN) on the toll-like receptor (TLR) signal transduction pathway as well as the expression of myeloid differentiation factor 88 (MyD88) and tumor necrosis factor (TNF) receptor-associated factor-6 (TRAF6) was investigated. SIN inhibition of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) proliferation and RA cartilage and subchondral bone ... more

H.C. Zhang; M.X. Liu; E.P. Wang; Z. Lin; G.F. Lv; X. Chen
Adiponectin; Coronary heart disease; Inflammatory factor; Ischemia factor; Osteoprotegerin

This study aimed to explore serum adiponectin and osteoprotegerin levels in patients with coronary heart disease (CHD) and their correlation with inflammatory and ischemia factors. From September 2010 to Augest 2010, 347 CHD patients were enrolled for a retrospective analysis. Serum lipoprotein phospholipase A2 (Lp-PLA2), hypersensitive C-reactive protein (hs-CRP), ischemia modified albumin ( ... more

H.L. Zhang; X. Jin
Autoimmune disease; Inflammatory factor; T lymphocyte subpopulation

Previous studies have shown a close correlation between the generation of B cell autoantibodies and imbalances in T lymphocyte subpopulations and the occurrence of disease. In this study, we have analyzed the effects of abnormal expression of CD4+CD25+-regulatory T cells, T lymphocyte subpopulations, immunoglobulins, complement factors, inflammatory factors, and adhesion molecules in the ... more

X.J. Zhang; H.Y. Zhou; Y. Li; X.J. Zhang; H.Y. Zhou; Y. Li
Colorectal cancer; Genetic polymorphism; HIV-1 infection; Leprosy; NLRP3; Rheumatoid arthritis

Using a meta-analysis framework, we investigated the association between the NLRP3 rs35829419 polymorphism and increased susceptibility to diverse diseases in humans. Relevant published studies were identified through a comprehensive and systematic electronic search, using the following scientific literature databases: Science Citation Index, the Cochrane Library, PubMed, Embase ... more

Q. Zhang; H.W. Fan; J.Z. Zhang; Y.M. Wang; H.J. Xing
Cyclooxygenase-2; Osteoarthritis; Rheumatoid arthritis; Synovial tissues

In this study, we investigated the differential expression profiles of cyclooxygenase-2 (COX-2) mRNA and proteins in osteoarthritis (OA) and rheumatoid arthritis (RA) patients to elucidate the role of COX-2 expression in the pathogenesis and development of these diseases and to provide novel drug targets for treating arthritis. A total of 60 patients who received arthroscopic surgeries ... more

H.W. Fan; G.Y. Liu; C.F. Zhao; X.F. Li; X.Y. Yang
IL-18; Meta-analysis; Polymorphism; Rheumatoid arthritis

Interleukin-18 (IL-18), an important proinflammatory cytokine, has been reported to play a potential pathological role in rheumatoid arthritis (RA). Results from previous studies on the association between IL-18 polymorphisms and RA are conflicting. To clarify this, an updated meta-analysis of all available studies on IL-18 polymorphisms and RA was conducted. Eligible articles were ... more

L.L. Li; X.F. Deng; J.P. Li; N. Ning; X.L. Hou; J.L. Chen; L.L. Li; X.F. Deng; J.P. Li; N. Ning; X.L. Hou; J.L. Chen; L.L. Li; X.F. Deng; J.P. Li; N. Ning; X.L. Hou; J.L. Chen
Autoimmunity; CD40; qPCR; Rheumatoid arthritis; SNP

The CD40 pathway is involved in the development and pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). Two single nucleotide polymorphisms (SNPs) in the CD40 gene, rs1883832 and rs4810485, are associated with susceptibility to inflammatory and autoimmune diseases and are thought to alter CD40 expression at the mRNA and protein level ... more

I.V. Román-Fernández; D.F. Ávila-Castillo; S. Cerpa-Cruz; S. Gutiérrez-Ureña; J. Hernández-Bello; J.R. Padilla-Gutiérrez; Y. Valle; M.G. Ramírez-Dueñas; A.L. Pereira-Suárez; J.F. Muñoz-Valle
Gene polymorphism; IL-27; Rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease with increasing activity of T lymphocytes and abnormal production of inflammatory cytokines. Interleukin-27 (IL-27), a multifunction cytokine with contradictory inflammatory effect. Polymorphism of IL-27 was reported to be predisposed to many inflammatory diseases and autoimmune diseases. We aimed to assess the ... more

A. Badawy; A.H. Mohamed; A.A. Enein; R. Qasem; E. Rizk; E. El-Masry; S. Abdellatif; M. Balata