Research Article

Related GMR Articles

Apoptosis; DNA damage; genomic instability; Inflammation; Isocyanates; Lung cancer

Lungs comprise the primary organ exposed to environmental toxic chemicals, resulting in diverse respiratory ailments and other disorders, including carcinogenesis. Carcinogenesis is a multi-stage phenomenon, which involves a series of genetic alterations that begin with genomic instability provoked by certain factors such as inflammation and DNA damage and end with the development of cancer. ... more

P.K. Mishra; A. Bhargava; G.V. Raghuram; S. Gupta; S. Tiwari; R. Upadhyaya; S.K. Jain; K.K. Maudar
gene fusions; genomic instability; healthy individuals; Leukemia; lymphoma

Hematopoietic neoplasias are characterized by recurrent chromosomal aberrations that result in the formation of gene fusions and the subsequent expression of chimeric proteins with unique properties. However, in recent years, different lymphoma/leukemia-associated rearrangements, such as BCR/ABL, IGH/BCL2, ETV6/RUNX1 and MLL duplications, have been detected in healthy individuals. The presence ... more

M.S. Brassesco
genomic instability; LOH; MSI; Ovarian cancer

Ovarian cancer is currently the most lethal gynecological malignancy in women. It is a heterogeneous and cytogenetically complex disease previously associated with genomic instability. Our purpose was to analyze microsatellite markers to determine patterns and levels of instability as well as possible correlations with histopathological parameters. Polymerase chain reaction was used to ... more

L.N.R. Alves; E.V. Wolfgramm; A.Kde Castro Neto; I.D. Louro
Down syndrome; Genetic polymorphism; Nondisjunction; Trisomy 21

The aim of the present study was to investigate the effect of polymorphisms C677T and A1298C in the methylenetetrahydrofolate reductase (MTHFR) gene, A2756G in methionine synthase reductase (MTR) gene and A80G in reduced folate carrier 1 (RFC1) gene, and plasma homocysteine (Hcy), on the maternal risk for Down syndrome (DS). Seventy-two DS mothers and 194 mothers who ... more

J.M. Biselli; E.M. Goloni-Bertollo; B.L. Zampieri; R. Haddad; M.N. Eberlin; E.C. Pavarino-Bertelli
Denizli; Down syndrome; Prevalence; Trisomy 21; Turkey

Down syndrome (DS) is the most frequent chromosome abnormality among live births. Its prevalence increases with maternal age, and can be diagnosed by antenatal screening. We examined prevalence variations of DS in Denizli, Turkey, through a retrospective study. Sixteen years of survey data were retrieved from the two main state hospital registries from records between 1994 and 2010. We ... more

I. Acikbas; A.G. Tomatir; B. Akdag; A. Köksal
Down syndrome; Folate; MTHFD; Polymorphisms; Transcobalamin gene

We examined whether polymorphisms in the methylenetetrahydrofolate dehydrogenase (MTHFD) and transcobalamin (TC) genes, which are involved in folate metabolism, affect maternal risk for Down syndrome. We investigated 76 Down syndrome mothers and 115 control mothers from Bengbu, China. Genomic DNA was isolated from the peripheral lymphocytes. Polymerase chain reaction and ... more

Y.P. Liao; D. Zhang; W. Zhou; F.M. Meng; M.S. Bao; P. Xiang; C.Q. Liu
Chromosome 21; Down syndrome; Han population; Quantitative fluorescence polymerase chain reaction; Short tandem repeats; Southeast China

Short tandem repeats (STRs) are highly polymorphic sequences and have been extensively used as genetic markers in mapping studies, disease diagnosis, and human identity testing. In this study, 11 STR markers on chromosome 21, including D21S1432, D21S11, D21S1246, D21S1412, D21S1437, D21S1442, D21S2039, D21S1270, D21S1435, D21S1409, and D21S1446, were analyzed in 740 unrelated Han ... more

Y.N. Zhu; S.M. Lu; M. Wang; F.X. Shen; Y. Chen; J.J. Hu
Cyclophosphamide; Cytotoxicity; Lubricant oils; Micronucleus

To ascertain whether used and re-refined lubricant oil absorbed through the skin can produce a genotoxic effect or cytotoxicity in mouse bone marrow cells, we examined the induction of micronucleated erythrocytes of peripheral blood after cutaneous application. Both re-refined and used lubricant oils showed a weak but significant induction of micronucleated polychromatic erythrocytes ... more

C.R. Oliveira-Martins; C.K. Grisolia
Chromosome aberration; Imidacloprid; Methamidophos; Micronucleus; Rat; Salmonella microsome assay

We examined the cytogenetic and genotoxic effects of the neonicotinoid insecticide imidacloprid and the organophosphate insecticide methamidophos, when administered alone or in combination. These insecticides were tested with the bone marrow chromosome aberration assay and micronucleus test in rats and by the bacterial mutation assay (Salmonella/microsome mutagenicity assay ... more

U. Karabay; G. Oguz
99mTc-MIBI; Genotoxicity; Micronucleus; Radiopharmaceutical

The radiotracer technetium-99m methoxyisobutyl isonitrile (99mTc-MIBI) has been widely used for myocardial blood flow imaging. We investigated the genotoxicity of 99mTc-MIBI in cultured human lymphocytes at the same concentration used in patients. Radioactivity doses were determined in whole blood at 5 min post-injection of 20 mCi 99mTc-MIBI in patients. ... more

S.J. Hosseinimehr; A. Ahmadi; D. Beiki; A. Mahmoudzadeh; M. Babaei; E. Habibi