Research Article

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12/21/2015
Breast cancer; G10398A mutation; Haplogroup

Mitochondrial DNA mutations have been found to play important roles in carcinogenesis. The most common G10398A mutation, a non-conservative amino acid substitution from Thr to Ala, seems to be involved in the tumorigenesis of breast cancer. Results from studies concerning this mutation remain inconclusive. In the current study, we first took clinical and molecular datasets from case- ... more

Y. Yu; F. Lv; H. Lin; G. Qian; Y.S. Jiang; L.X. Pang; Y.P. Wang; X.F. Wang; Y.M. Kang; C.B. Li; Q. Liu; J.Z. Xu; W. You
12/17/2015
Meta-analysis; Polymorphism; Tumor necrosis factor-α; Vitiligo

Several case-control studies have been conducted to investigate the association between the tumor necrosis factor-α (TNF-α)-308G/A polymorphism and vitiligo risk. However, the results of these studies are inconsistent; therefore, we attempted to comprehensively evaluate the association between TNF-α-308G/A polymorphism and vitiligo risk via a meta-analysis. Studies reporting the ... more

G. Nie; J.H. Qi; C.W. Huang; T. Yang; N. Shi; Y.J. Chen
02/01/2023
Meta-analysis; Neurodegenerative diseases; Polymorphisms; Systematic review; VEGF-A

Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are degenerative scleroses with unclear etiology. Vascular endothelial growth factor A (VEGF-A) is a growth factor that plays multiple roles in the central nervous system.  Previous studies indicated a potential association between polymorphisms in this gene and the susceptibility of ALS and ... more

J.O. Costa; C.C.P. Costa; N.S. Lima; K.F. Santos; A.A.S. Reis; R.S. Santos
02/01/2023
Meta-analysis; Neurodegenerative diseases; One-carbon metabolism; Polymorphisms; Systematic review

The folate cycle is a biochemical pathway that plays an important role in the development and maintenance of the nervous system. Biocompounds synthesized in this cycle must be carefully regulated, since the accumulation of some substances can be neurotoxic and increase susceptibility to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and ... more

J.V.A. Neves; N.S. Lima; C.C.P. Costa; K.F. Santos; A.A.S. Reis; R.S. Santos
08/03/2015
-2578C/A; Breast cancer; Genetic polymorphism; Meta-analysis; VEGF; 405G/C

This study aimed to analyze the association between the 405G/C and -2578C/A polymorphisms of the vascular endothelial growth factor (VEGF) gene and breast cancer risk by meta-analysis. A systematic computerized search of PubMed, Google Scholar, and Web of Science databases was performed to identify relevant publications. After rigorous searching and screening, 9 eligible case- ... more

Y. Zhang; Y.F. Yu; J.Z. Wang; H. Jia
12/08/2015
Ahr; Breast cancer; Gene; Meta-analysis; Polymorphism

Published data regarding the association between aryl hydrocarbon receptor (Ahr) rs2066853 polymorphism and the risk of breast cancer shows conflicting results. We performed a meta-analysis on 2999 patients and 3050 controls from three related case-control studies to estimate the association between Ahr rs2066853 polymorphism and the risk of breast cancer. The protocol was approved by ... more

Y. Li; H.Z. Qin; Q. Song; X.D. Wu; J.H. Zhu
11/25/2015
Angiotensin II type-1 receptor; Breast cancer; Meta-analysis; Polymorphism

Numerous studies have evaluated the association between the angiotensin II type-1 receptor (AGTR1) gene A1166C polymorphism and breast cancer risk. However, the specific association is controversial. The aim of the present study was to derive a more precise estimation of the relationship. A comprehensive research was conducted of the PubMed and the Google Scholar databases through ... more

L. Li; F. Wang; P.W. Lv; M.Z. Zhu; J.J. He; G.C. Guo; Y.T. Gu; M.L. Han
06/15/2010
AGER; Genetic polymorphisms; Gestational diabetes; RAGE; Single nucleotide polymorphisms

The receptor for advanced glycation end products (RAGE or AGER) is a multiligand member of the immunoglobulin superfamily. RAGE is expressed in several tissues, including human myometrium, chorionic villi and placenta. Advanced glycation end products are the best studied ligands of RAGE; they have pro-inflammatory actions in human gestational tissues, ... more

I.C.R. Santos; D.R. Daga; H.R. Frigeri; R.R. Réa; A.C.R. Almeida; E.M. Souza; F.O. Pedrosa; C.M.T. Fadel-Picheth; G. Picheth
09/01/2015
Circulating tumor cells; Lung cancer; Non-small cell lung cancer

We explored the expression and clinical significance of circulating tumor cells (CTCs) in patients with advanced non-small cell lung cancer (NSCLC). Sixty-six patients with advanced NSCLC at the Oncology Department of Jinzhou Hospital were selected as an observation group between February and December 2013. Healthy volunteers and 20 benign lung disease patients were taken as a control ... more

Y.H. Xu; J. Zhou; X.F. Pan
12/02/2015
8-Oxoguanine DNA glycosylase rs1052133; Base excision repair; Lung cancer; poly(ADP-ribose) polymerase 1 rs1136410; Single nucleotide polymorphisms; X-ray repair cross-complementing group 1 rs25487

Base excision repair (BER) plays an important role in maintaining genome integrity and anti-cancer drug resistance. Single nu­cleotide polymorphisms (SNPs) in BER genes were detected in 500 lung cancer patients and 500 cancer-free controls. A logistic regression model was applied to analyze the relationship between lung cancer susceptibility and BER SNPs coupled with a wide range of ... more

X. Wang; K.W. Ma; Y.G. Zhao; G.J. Wang; W. Li

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