Research Article

Related GMR Articles

05/20/2008
chronic renal disease; hemodialysis patients; Micronucleus; Mutagenicity; peritoneal dialysis patients

Patients with chronic renal disease have an increased incidence of cancer. It is well known that long periods of hemodialysis treatment are linked to DNA damage due to oxidative stress. This genotoxic effect may cause the loss of chromosome fragments, or even entire chromosomes, which form micronuclei after cell division, and can be detected by the micronucleus test. In the present case- ... more

J.M. Roth; R.G. Restani; T.T.S. Gonçalves; S.L.S. Sphor; A.B. Ness; M.G. Martino-Roth; G.L. Garcias
08/05/2011
Apoptosis; HSIL; LSIL; Micronucleus

We evaluated micronucleus and apoptosis occurrence among women with normal smears and women with different kinds of cervical abnormalities, i.e., inflammatory processes and low- and high-grade squamous intraepithelial lesions (N = 12, N = 10 and N = 27, respectively). The sample included 59 women who were seen at a public medical service for cervical cancer prevention in Feira de Santana, ... more

G.M.A. Aires; J.R.C. Meireles; P.C. Oliveira; J.L. Oliveira; E.L. Araújo; B.C. Pires; E.S.A. Cruz; N.F. Jesus; C.A.B. Pereira; E.M.M. Cerqueira
09/28/2010
Exfoliated cells; Hairdressers; Micronucleus; Micronucleus tests

Hairdressers are exposed daily to chemical substances, such as dyes, chemical straighteners and curling chemicals, which can be absorbed, inhaled or possibly ingested. We analyzed the frequency of micronuclei (MNC) in exfoliated cells of the buccal mucosa of 50 hairdressers and 50 controls in Pelotas, RS, Brazil. An assessment was carried out on the incidence of MNC, binucleated cells ( ... more

L.N. Rickes; M.C. Alvarengo; T.M. Souza; G.L. Garcias; M.G. Martino-Roth
06/11/2010
Biomonitoring; Chromosome aberration; Indoor exposure; Micronucleus; Petroleum exposure

We looked for genotoxic effects in laboratory personnel routinely exposed to petroleum derivate compounds in an indoor environment. The exposed group of 21 workers from the Fuel Quality Control Laboratory of the Brazilian Petroleum Agency was matched with a group of 10 people from the staff of the Brazilian Ministry of Health. Chromosome aberrations in peripheral blood lymphocytes, ... more

A.E.O. Araújo; B.P. Mezzomo; I. Ferrari; C.K. Grisolia
08/29/2013
Genotoxicity; Micronucleus; Nickel; Oral epithelial cells

The micronucleus (MN) assay evaluates the effects of low doses of genotoxic carcinogens and can detect structural lesions that survive mitotic cycles. The objective of this study was to determine both the genotoxicity of nickel (Ni) in buccal epithelial cells and the urinary excretion of Ni in children with metal crowns. This was a prospective longitudinal study based on 37 patients selected ... more

J. Morán-Martínez; K.D.Monreal de Luna; N.D. Betancourt-Martínez; P. Carranza-Rosales; J.G. Contreras-Martínez; M.C. López-Meza; O. Rodríguez-Villarreal
11/12/2014
Chemoprevention; Chromosome aberration; Functional food; Methyl methanesulfonate; Micronucleus

In this study, we evaluated the mutagenic and antimutagenic activities of carrageenan, a sulfated polysaccharide, and described its mode of action by using an Allium cepa assay. The results indicate that carrageenan is not mutagenic, rather it has significant chemopreventive potential that is mediated by both demutagenic and bio-antimutagenic activities. This compound can adsorb ... more

C.I. Nantes; J.R. Pesarini; M.O. Mauro; A.C.D. Monreal; A.D. Ramires; R.J. Oliveira
07/07/2014
Comet assay; Cordia ecalyculata; Micronucleus; Mutagenesis; Spirulina maxima

Obesity is one of the most important nutritional disorders, and can be currently considered as an epidemic. Although there are few weight reduction drugs available on the market, some new drug candidates have been proposed, including Cordia ecalyculata, a Brazilian plant with anorectic properties, and Spirulina maxima, a cyanobacterium with antioxidant and anti-genotoxic ... more

R.P. Araldi; B.M. Rechiutti; T.B. Mendes; E.T. Ito; E.B. Souza
06/11/2014
Annonaceae; Immunomodulation; Micronucleus; Teratogenicity; Toxicity

Plants such as Annona nutans used in folk medicine have a large number of biologically active compounds with pharmacological and/or toxic potential. Moreover, pregnant women use these plants indiscriminately, mainly in the form of teas, without being aware of the harm that they could cause to the health of the embryo/fetus. Therefore, it is necessary to analyze the potential ... more

C.A. Gonçalves; N.L. Silva; M.O. Mauro; N. David; A.L. Cunha-Laura; S.A. Auharek; A.C.D. Monreal; M.C. Vieira; D.B. Silva; F.J.L. Santos; J.M. Siqueira; R.J. Oliveira
04/30/2014
Allium cepa test; Chemoprevention; Comet assay; Micronucleus

It is estimated that 60% of anticancer drugs are derived directly or indirectly from medicinal plants. Schinus terebinthifolius Raddi (Anacardiaceae) is traditionally used in Brazilian medicine to treat inflammation, ulcers, and tumors. Because of the need to identify new antimutagenic agents and to determine their mechanism of action, this study evaluated the chemopreventive ... more

L.E.S. Fedel-Miyasato; A.S.N. Formagio; S.A. Auharek; C.A.L. Kassuya; S.D. Navarro; A.L. Cunha-Laura; A.C.D. Monreal; M.C. Vieira; R.J. Oliveira
07/31/2006
Buccal cells; DNA extraction; Fragile X syndrome; Mental retardation

Fragile X syndrome is one of the most frequent causes of mental retardation. Since the phenotype in this syndrome is quite variable, clinical diagnosis is not easy and molecular laboratory diagnosis is necessary. Usually DNA from blood cells is used in molecular tests to detect the fragile X mutation which is characterized by an unstable expansion of a CGG repeat in the fragile X ... more

D.M. Christofolini; M.V.N. Lipay; M.A.P. Ramos; D. Brunoni; M.I. Melaragno

Pages