Research Article

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03/04/2016
Cancer; Cervical neoplasms; Hypoxia-inducible factor 1α; Immunohistochemistry; Squamous cells; Vasculogenic mimicry

In this study, the existence of vasculogenic mimicry (VM) in cervical squamous cell carcinoma was investigated. To this end, the relationship between hypoxia-inducible factor 1α (HIF-1α) and the development, infiltration, and metastasis of cervical squamous cell carcinoma was studied. Between January 2010 and December 2010, 67 human cervical squamous carcinoma tissue samples were ... more

T.J. Zhou; X.H. Huang; L. Gong; L. Xiang; T.J. Zhou; X.H. Huang; L. Gong; L. Xiang
1/23/2017
Animals; Biomarkers; Drugs, Chinese Herbal; Endometrium; Estrous cycle; Female; Flavonoids; Immunohistochemistry; Rats

This study aimed to investigate the effect of icariin (ICA) on thin endometrium in a rat model. To this end, 6- to 8-week-old female Sprague Dawley rats (105) were randomly divided into 7 groups: untreated, vehicle-treated (lavage with NaCl), high-dose ICA (lavage with ICA at 200 mg∙kg∙day), medium-dose ICA (lavage ICA at 100 mg∙kg∙day), low-dose ICA (lavage with ICA at 50 mg∙kg∙day), sham ... more

A.W. Le; Z.H. Wang; X.Y. Dai; T.H. Xiao; R. Zhuo; B.Z. Zhang; Z.L. Xiao; X.J. Fang
1/23/2017
Animals; Cognition Disorders; Disease Models, Animal; Gene expression; Hippocampus; HIV Envelope Protein gp120; Humans; Immunohistochemistry; Maze Learning; Rats; Receptors, Purinergic P2X7

To investigate the role of the P2X receptor in learning and memory dysfunction induced by HIV-1 envelope glycoprotein gp120 (gp120), we established HIV-1-associated dementia (HAD) animal models by intracerebroventricular (ICV) infusion of gp120 in rats. We observed gp120-induced cognitive dysfunction in the radial arm water maze test. Results showed that rats in the gp120 groups had longer ... more

Y. Liu; G.Q. Chen; B.Y. Liu; Q. Chen; Y.M. Qian; S.S. Qin; C.L. Liu; C.S. Xu
3/08/2017
Androgens; Animals; Cestoda; Gonadal Steroid Hormones; Immunohistochemistry; Receptors, Androgen; Receptors, Estrogen; Receptors, Progesterone

Sex hormone receptors play critical roles in development and reproduction. However, it is not known whether they exist in Raillietina tapeworms, and if they do, whether they have a similar function to that in vertebrates. We examined the immunohistochemical distributions of androgen receptors (ARs), estrogen receptors (ERs), and progesterone receptors (PRs) in the tissues of two tapeworm ... more

L. Chen; Y.M. Sun; L. Mu; Y. Zeng; H.Y. Li; T.H. Yang
3/30/2017
Adult; Aged; Antineoplastic Agents; Caspase 3; Caspase Inhibitors; Disease-free survival; Everolimus; Female; Humans; Immunohistochemistry; Ki-67 Antigen; male; Middle Aged; Neuroendocrine Tumors; Protein Kinase Inhibitors

Tumors, especially neuroendocrine tumors (NETs), can cause adverse effects on human health. The expression and significance of Ki-67 and caspase-3 in NET remain to be further explored. Everolimus is an important drug used for the treatment of NETs. In this study, we aimed to investigate whether everolimus exerts anti-tumor effects by suppressing the expression of Ki-67 and caspase-3 in NET. ... more

H.Y. Zhang; X.B. Cheng; Y. Li; L.D. Jin; H.P. Yin
12/31/2019
Epithelial-mesenchymal transition; Immunohistochemistry; Survival; Vimentin

Vimentin is a cytoskeletal protein belonging to a family of intermediate filaments whose expression has been studied in human cancers due to its association with the mesenchymal epithelial transition, a cancer reactivation event that results in complex alterations in the expression of genes involved in the invasion and metastasis processes. Studies on the ... more

F.C. Santana; J.E.P. Ramos; N.A. Nogueria; L.S.D. Líbera; T. Aparecida; S.H. Rabelo; V.A. Saddi
03/29/2021
Hematoxylin-eosin; Immunohistochemistry; Lymph node; Metastasis; Nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a rare cancer in the Western hemisphere (1 case per 100,000 individuals). Conversely there are some areas, such as Southern China, Southeast Asia (Vietnam), the Mediterranean basin and Alaska, where morbidity reaches 80 per 100,000 individuals. Detecting cervical lymph node metastasis is important because it helps recommend the ... more

N.D. Phuc; L.M. Ky; N.T. Binh; N.T. Tuan; N.T.K. Van; T.X. Hai; V.T.M. Thuc
09/22/2015
Body measurement traits; Carcass quality traits; SNP; STAT3

Previous studies have shown that the signal transducer and activator of transcription 3 gene (STAT3) is involved in lipid storage and energy metabolism, suggesting that STAT3 is a potential candidate gene that affects body measurement and carcass quality traits in animals. Therefore, the aim of this study was to identify polymorphisms in bovine STAT3 and to ... more

N. Song; L.S. Gui; H.C. Xu; S. Wu; L.S. Zan
09/08/2015
CRH; Economic traits; Hanwoo; Korean cattle; POMC; SNP

The corticotrophin-releasing hormone (CRH) and proo­piomelanocortin (POMC) genes are considered to play an important role in the growth and development of mammals. In this study, the bovine CRH and POMC genes were characterized to detect genetic variation at these loci in relation to economic traits in Korean cattle (Hanwoo). Nine single ... more

J. Seong; H.S. Kong
08/14/2015
Association study; Schizophrenia; SNP; VRK2 gene

Previous studies have found that the vaccinia related kinase 2 gene (VRK2) polymorphism was associated with schizophrenia (SCZ) in the worldwide population. This association was further supported by VRK2 mRNA expression patterns and brain structure variations. Here, we analyzed four single nucleotide polymorphisms (SNPs) of the VRK2 gene in a total population of 893 ... more

B. Zhang; C.Y. Gao; H.B. Zhang; B. Yang; J.F. Yin; S.G. Wei; Y.S. Zhu; X.N. Jia; S.B. Li

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