Research Article

Related GMR Articles

02/22/2016
Brazilian women; Breast cancer; p53 protein; Restriction enzymes; SNP; TP53

The association between TP53 gene polymorphisms and breast cancer (BC) in Brazilian women is a controversial topic. In this cross-sectional study, we evaluated the association between clinical pathological variables and three polymorphisms (TP53*11, TP53*72, and TP53*248) in BC patients and controls. Genomic DNA was extracted from the blood cells of 393 ... more

B.C. Almeida; J.P.F.O. Kleine; C.M. Camargo-Kosugi; M.R. Lisboa; C.N. França; J.P. França; I.D.C.G. Silva; B.C. Almeida; J.P.F.O. Kleine; C.M. Camargo-Kosugi; M.R. Lisboa; C.N. França; J.P. França; I.D.C.G. Silva
10/24/2016
Autoimmunity; CD40; qPCR; Rheumatoid arthritis; SNP

The CD40 pathway is involved in the development and pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). Two single nucleotide polymorphisms (SNPs) in the CD40 gene, rs1883832 and rs4810485, are associated with susceptibility to inflammatory and autoimmune diseases and are thought to alter CD40 expression at the mRNA and protein level ... more

I.V. Román-Fernández; D.F. Ávila-Castillo; S. Cerpa-Cruz; S. Gutiérrez-Ureña; J. Hernández-Bello; J.R. Padilla-Gutiérrez; Y. Valle; M.G. Ramírez-Dueñas; A.L. Pereira-Suárez; J.F. Muñoz-Valle
11/03/2016
High-resolution melting; Pinctada fucata; SNP; Transcriptome sequencing

The pearl oyster Pinctada fucata is an important commercial marine shellfish that is cultured for producing saltwater pearls. In this study, 468 single nucleotide polymorphisms (SNPs) were screened from P. fucata transcriptome data, and 119 polymorphic SNPs were successfully isolated by a two-step small-amplicon high-resolution melting assay. Of ... more

S.G. Fan; J.F. Wei; Y.H. Guo; G.J. Huang; D.H. Yu; S.G. Fan; J.F. Wei; Y.H. Guo; G.J. Huang; D.H. Yu; S.G. Fan; J.F. Wei; Y.H. Guo; G.J. Huang; D.H. Yu
12/01/2017
Carcass composition; Carcass quality; Growth; SNP
The objective of the current study was to evaluate single
nucleotide polymorphisms (SNP) for potential growth and carcass trait
associations located in two previously described quantitative trait loci
(QTL) regions associated with bovine respiratory disease. A population
of 323 crossbred steers sired by five purebred sire breeds between 2010- ... more
S. Mizell; S.L. Miller; A.M. Royer; K.J. Thornton; M.D. Garcia
08/20/2019
Genetic susceptibility; Polymorphism; Protein tyrosine kinase 2; SNP; Type 1 diabetes mellitus

Type 1 diabetes mellitus (T1D) is considered a polygenic disease that is influenced by environmental factors and autoimmune responses to autoantibodies, resulting in metabolic abnormalities. Tyrosine kinase 2 (TYK2) is involved in type I interferon signaling in beta cells, and TYK2 polymorphism rs2304256 has been associated with T1D. We ... more

V. Graciolo; M. Welter; L.P. Campos; B.R. Martins; S.W. Souza; S.N. França; R.R. Réa; G. Picheth; F.G.M. Rego
09/26/2019
Blanco Orejinegro; Coefficient of adaptability; Heat tolerance coefficient; Sanmartinero; SNP

The aim of this study was to perform a genome wide association study for the coefficient of adaptability, the heat tolerance coefficient, age at first calving and calving interval, using 58,868 and 57,482 single nucleotide polymorphisms obtained from 1262 Blanco Orejinegro and 742 Sanmartinero individuals, implementing a single-step-genomic-BLUP (ssGBLUP) ... more

C. De León; C. Manrique; R. Martínez; J.F. Rocha
12/31/2019
Artificial neural network; Classification; Decision tree; Genome-wide analysis; Milk yield; SNP

We compared two techniques of machine learning for the identification of cows that will be good producers of milk based on their genome-wide information. Data from a genome-wide genotyping panel, consisting of 164312 single nucleotide polymorphism markers (SNPs), within the 29 autosomal chromosomes, from 1092 Holstein cow samples were used for this study. ... more

E. Rodríguez; J. Waissman; P. Mahadevan; C. Villa; B.L. Flores; R. Villa

Pages