Research Article

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12/22/2015
Biomarker; Cervical cancer; Cervical intraepithelial neoplasia; miR-196a; Prognosis

Previous studies have reported that miR-196a is upregulated in cervical cancer tissues and cell lines. However, whether serum miR-196a is increased in patients with cervical cancer or cervical intraepithelial neoplasia (CIN), and its potential clinical value remained unknown. In total, 105 cervical cancer patients, 86 CIN patients, and 50 healthy volunteers were recruited. Quantitative ... more

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12/17/2015
Cervical cancer; HLA-DQB1; PCR-SBT; Predisposing genes

In Uyghur women, mortality rates from cervical cancer are amongst the highest in the nation, and genetic susceptibility probably plays a role in the pathogenesis of the disease. We investigated the correlation between polymorphisms of the HLA-DQB1 allele and cervical cancer in Xinjiang Uyghur women. Cervix tissue samples from 80 cases of cervical cancer and 80 cases of cervicitis were ... more

L. Han; S. Husaiyin; L. Wang; K.D. Wusainahong; X. Fu; M. Niyazi
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Papillary thyroid carcinoma; Pathogenesis; Signaling pathway; Survivin

The purpose of this study was to assess the correlation between the survivin gene and the occurrence and pathogenesis of papillary thyroid carcinoma (PTC). Sixty patients with PTC and no preoperative chemotherapy were recruited for the study and 30 thyrophyma patients receiving operative treatment in Drum Tower Hospital (Nanjing, China) were included as the control group. The protein ... more

J.Y. Li; J. Shi; J.F. Sang; Y.Z. Yao; X.C. Wang; L. Su
09/08/2015
A431 cells; Apoptosis; Bcl-2; Berberine; Proliferation; Squamous cell carcinoma

Berberine (BBR) is a natural alkaloid with significant anti-tumor activity against many types of cancer cells. In this study, we investigated the molecular mechanisms employed by BBR to repress the proliferation and growth of skin squamous cell carcinoma A431 cells. Berberine was reported to inhibit the proliferation of A431 cells in a dose- and time-dependent manner and was observed to induce ... more

D.X. Li; J. Zhang; Y. Zhang; P.W. Zhao; L.M. Yang
08/03/2015
Bcl-2; Hypoxic ischemic brain injury; IL-18; Montelukast; Rat brain tissue; TERT

The aim of this study was to investigate the effect of mon­telukast on the expression of interleukin (IL)-18, telomerase reverse tran­scriptase (TERT), and Bcl-2 in the brain tissue of neonatal rats with hypox­ic-ischemic brain damage (HIBD). To establish the model of HIBD, 8% oxygen was applied to rats after the unilateral carotid artery was ligated. Twenty rats were randomly assigned ... more

J.L. Liu; X.H. Zhao; D.L. Zhang; J.B. Zhang; Z.H. Liu
07/13/2015
Acute cerebral infarction; Apoptosis; Bcl-2

We aimed to investigate the influence of lentiviral-medi­ated Bcl-2 overexpression in cerebral tissues of rats with acute cerebral infarction. Forty-five rats were randomly divided into sham, model, and treatment groups. The sham and model groups were administered a control lentiviral vector via the intracranial arteries 10 days before surgery, while the treatment group received lentivirus ... more

H.R. Zhang; J.H. Peng; G.Y. Zhu; R.X. Xu
06/21/2016
Apoptosis; Bcl-2; Borax; HepG2 cells; Mitochondrial membrane potential; p53

Borax, a boron compound and a salt of boric acid, is known to inhibit the growth of tumor cells. HepG2 cells have been shown to be clearly susceptible to the anti-proliferative effects of borax. However, the specific mechanisms regulating this effect are poorly understood. This study aimed to investigate the pathways underlying the growth inhibition induced by borax in HepG2 cells. The ... more

Y. Wei; F.J. Yuan; W.B. Zhou; L. Wu; L. Chen; J.J. Wang; Y.S. Zhang; Y. Wei; F.J. Yuan; W.B. Zhou; L. Wu; L. Chen; J.J. Wang; Y.S. Zhang
09/21/2015
Breast cancer; GIT2; Metastasis; MTERF; Multiplex RT-PCR

Quantitative multiplex reverse transcriptase-polymerase chain reaction was developed for the simultaneous detection of multiple-gene expression levels of formalin-fixed, paraffin-embedded breast cancer samples. Candidate genes were selected from previous microarray data relevant to breast cancer markers that had the potential to serve as predictive markers for metastatic risk. This multiplex ... more

S. Sirirattanakul; P. Wannakrairot; T. Tencomnao; R. Santiyanont
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EGFR; FISH; Metastasis; NSCLC

The aim of this study was to explore epidermal growth factor receptor (EGFR) gene amplification and its relationship with cancer invasion and metastasis in non-small cell lung cancer (NSCLC). EGFR amplification in 45 patients with NSCLC and 15 subjects with normal lung tissues was detected by fluorescence in situ hybridization. The relationship between EGFR ... more

X.F. Jia; J. Li; H.B. Zhao; J. Liu; J.J. Liu
12/14/2015
Metastasis; MiR-134; Osteosarcoma; Prognosis; Proliferation

Dysregulation of microRNA (miR) is often associated with cancer development and progression. Aberrant expression of miR-134 has been found in some types of cancer. However, its expression and function in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-134 in osteosarcoma tumorigenesis and development. The expression level of miR-134 was quantified by ... more

Y. Bao; L. Peng; J. Ma; K. Liu; W. Li

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