Research Article

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10/09/2015
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Although many studies have investigated the association of the APOA5 -1131T/C polymorphism with coronary artery disease (CAD), definite conclusions have not been drawn. To understand the effects of the APOA5 -1131T/C polymorphism on the risk of developing CAD, we performed an updated meta-analysis in the Chinese population. Relevant studies published till April 2015 were identified from ... more

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CCDC26; Glioma; Meta-analysis; Polymorphism; rs4295627

The association between the CCDC26 rs4295627 single nucleotide polymorphism (SNP) and the glioma risk has been studied previously, but these studies have yielded conflicting results. The aim of the present study is to analyze this association more vigorously, by means of a meta-analysis. A comprehensive literature search was performed in databases PubMed and EMBASE. Six articles ... more

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IL-8; Meta-analysis; Periodontitis; Polymorphism

The -251A/T polymorphism in the anti-inflammatory cytokine interleukin-8 (IL-8) gene has been implicated in susceptibility to periodontitis; however, this correlation has not been elucidated. In this meta-analysis, we investigated the association between the IL-8 -251A/T polymorphism and the risk of periodontitis. All eligible case-control studies ... more

Z.J. Yang; X.P. Tang; Q.G. Lai; J.B. Ci; K.F. Yuan; Z.J. Yang; X.P. Tang; Q.G. Lai; J.B. Ci; K.F. Yuan; Z.J. Yang; X.P. Tang; Q.G. Lai; J.B. Ci; K.F. Yuan
06/03/2016
25-(OH)2D3]; Active vitamin D3 [1; Endothelin; Macrovasculopathy; T2DM; TNF-α

To investigate the protective effect of the active form of vitamin D3, 1,25-(OH)2D3, on macrovasculopathy in rats with type 2 diabetes mellitus (T2DM), 8-week-old male Sprague-Dawley rats were randomly divided into control group, T2DM group, and treatment group. The T2DM model was established after 6 weeks by administering an intraperitoneal injection of ... more

R. Ma; X.L. Deng; G.L. Du; C. Li; S. Xiao; Y. Aibibai; J. Zhu; R. Ma; X.L. Deng; G.L. Du; C. Li; S. Xiao; Y. Aibibai; J. Zhu
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Chinese Hui population; Polymorphism; TCF7L2; Type 2 diabetes mellitus

Diabetes is one of costly chronic diseases. Previous studies across several ethnicities have shown that polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene were strongly associated with susceptibility to type 2 diabetes (T2DM). In the present study, the association between the TCF7L2 gene and the susceptibility to T2DM in a Chinese Hui population was interrogated ... more

Y. Yang; J.R. Xu; Y.J. Wang; X.M. Liu
09/28/2015
Diagnosis; Enzyme-linked immunospot; Meta-analysis; Tuberculous pleurisy

Current methods for diagnosing tuberculous pleurisy are poor. Some studies have explored the diagnostic value of a pleural effusion enzyme-linked immunospot (ELISPOT) assay, but its accuracy remains controversial. Therefore, we performed a meta-analysis of the existing evidence on the ability of the ELISPOT assay to diagnose tuberculous pleurisy. We systematically searched PubMed, Google ... more

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Chronic obstructive pulmonary disease; Gene polymorphism; Meta-analysis; Vitamin D-binding protein

Gene polymorphism of vitamin D-binding protein (VDBP) correlates with chronic obstructive pulmonary disease (COPD), but the results remain inconclusive. We aimed to explore the association between VDBP gene polymorphism and COPD. We searched MEDLINE, Embase, Web of Science, and China National Knowledge Infrastructure for publications addressing the association between VDBP gene ... more

Y.L. Wang; H. Kong; W.P. Xie; H. Wang
09/21/2015
COL1A1; Gene polymorphism; Meta-analysis; Osteoporosis

Studies investigating the association between the COL1A1 gene -1997G/T polymorphism and the risk of osteoporosis in postmenopausal women have reported conflicting results. We performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship. We conducted searches of the published literature in the ... more

K.H. Yu; J. Tang; C.Q. Dai; Y. Yu; J.J. Hong
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Cervical carcinoma; Gene polymorphism; Meta-analysis; XRCC1

Numerous studies have evaluated the association between Arg399Gln polymorphism of DNA repair gene XRCC1 and cervical carcinoma risk. However, the specific association is still controversial. To assess the relationship between XRCC1 Arg399Gln polymorphism and cervical carcinoma, we conducted a comprehensive meta-analysis of 10 case-control studies with 2051 cervical carcinoma cases and ... more

D.Y. Liu; H.C. Liang; X.M. Xiao
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Interleukin 21; Meta-analysis; Polymorphism; Systemic lupus erythematosus

Several case-control studies have been conducted to investigate the association between Interleukin-21 (IL-21) polymorphisms and systemic lupus erythematosus (SLE) susceptibility, and most of the studies focused on IL-21 rs907715 and rs2221903 polymorphisms. Given the inconsistent results from these studies, the present meta-analysis aimed to obtain a more precise estimate of the ... more

J.H. Qi; J. Qi; L.N. Xiang; G. Nie

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