Research Article

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The human IL6 [interleukin 6 (interferon, beta 2)] gene encodes IL-6, a cytokine which not only plays regulatory roles in inflammation, but may be also involved in the progression of cancer. Rs1800796 is a single nucleotide polymorphism (SNP) in the promoter region of IL6, and is associated with IL-6 production. A number of studies have been carried out to determine ... more

Y. Du; L. Gao; K. Zhang; J. Wang
10/19/2015
ERCC2; Glioma; Meta-analysis; rs13181

Several studies have focused on the association between the ERCC2 rs13181 polymorphism and glioma risk, but the results were inconclusive. We aimed to conduct a meta-analysis to investigate the role of ERCC2 rs13181 on the risk of glioma. We searched and collated the relevant studies in both Chinese and English through the PubMed, Web of Science, Cochrane Library, and ... more

T.L. Jia; H.J. Wu; H.B. Wang; W.B. Ma; B. Xing
01/08/2016
Adiponectin; Meta-analysis; Nonalcoholic fatty liver disease; Polymorphism

Numerous epidemiological investigations have evaluated the association between adiponectin gene T45G polymorphism and risk of nonalcoholic fatty liver disease (NAFLD). However, the results of these studies have proven to be inconsistent. Therefore, we conducted a meta-analysis to obtain a more accurate estimation of this association. Published articles were retrieved from PubMed and Web ... more

W. Zhang; L.Q. Zhu; X.L. Huo; J. Qin; G.Y. Yuan; W. Zhang; L.Q. Zhu; X.L. Huo; J. Qin; G.Y. Yuan; W. Zhang; L.Q. Zhu; X.L. Huo; J. Qin; G.Y. Yuan
10/17/2016
Clinically negative node; Meta-analysis; Radical neck dissection; Radiotherapy; Supraglottic carcinoma

The purpose of this study was to evaluate the treatment of clinically negative cervical lymph nodes in supraglottic carcinoma by a meta-analysis. The search words were “supraglottic carcinoma”, “cervical lymph nodes negative/cN0”, “radical neck dissection”, and “radiotherapy”. The databases included the Chinese biomedical literature database, Medline, Cochrane ... more

Y.H. Liu; Z.W. Du
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IFIH1; Meta-analysis; SLE; SLE clinical manifestations; SNPs

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder presenting heterogeneous clinical manifestations. A number of genes involved in SLE susceptibility are related to the type I interferon (IFN) pathway. IFN mediates innate immune responses and its increased levels contribute to the breakdown of peripheral tolerance. Interferon-induced helicase C ... more

deAzevêdo Silva; S.C. Lima; C. Addobbati; R. Moura; L.A.Cavalcanti Brandão; J.A.Trés Pancoto; E.A. Donadi; S. Crovella; P. Sandrin-Garcia
11/03/2016
Gestational diabetes mellitus; Meta-analysis; PPARs; Pro12Ala polymorphism

The relationship between the Pro12Ala polymorphism of PPARγ and the risk of gestational diabetes mellitus remains unresolved. Here, we attempted to resolve this inconsistency. Case-control studies pertaining to the effect of the Pro12Ala polymorphism in the PPARγ protein and risk of gestational diabetes mellitus were extracted from the ... more

H.L. Shuai; X.Z. Lin; D.L. Chen; P. Li; X. Luo
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ACE I/D polymorphism; Diabetic nephropathy; Genetic association; Meta-analysis; Systematic reviews

The angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism could influence predisposition for diabetic nephropathy (DN) by vascular modulation in the kidney, through a direct effect on cellular hypertrophy. However, studies on the association between this polymorphism and DN report conflicting results. To help determine if this association ... more

L.C. Silveira; E.G. da Silva; R.M. Azevedo; L.R.Bdos Anjos; R.F. Chagas; E.C. Alcântara; R.S. Santos; A.A.S. Reis
02/01/2023
Meta-analysis; Neurodegenerative diseases; Polymorphisms; Systematic review; VEGF-A

Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are degenerative scleroses with unclear etiology. Vascular endothelial growth factor A (VEGF-A) is a growth factor that plays multiple roles in the central nervous system.  Previous studies indicated a potential association between polymorphisms in this gene and the susceptibility of ALS and ... more

J.O. Costa; C.C.P. Costa; N.S. Lima; K.F. Santos; A.A.S. Reis; R.S. Santos
02/01/2023
Meta-analysis; Neurodegenerative diseases; One-carbon metabolism; Polymorphisms; Systematic review

The folate cycle is a biochemical pathway that plays an important role in the development and maintenance of the nervous system. Biocompounds synthesized in this cycle must be carefully regulated, since the accumulation of some substances can be neurotoxic and increase susceptibility to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and ... more

J.V.A. Neves; N.S. Lima; C.C.P. Costa; K.F. Santos; A.A.S. Reis; R.S. Santos
09/25/2015
Coronary artery disease; IL-17A; IL-17F; Polymorphism

A case-control study was conducted to investigate the association between genetic variants of IL-17A rs2275913 and IL-17F rs763780 and the development of coronary artery disease (CAD) in a Chinese population. A total of 306 individuals with CAD and 306 unaffected individuals were enrolled from the Zhengzhou People’s Hospital between May 2012 and May 2014. The IL-17A ... more

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