Research Article

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Members of the basic leucine zipper family, as bZIP19, are considered to be essential regulators of the adaptation to zinc deficiency. Knowing that this gene as well as its targets are conserved in the plant kingdom, we followed an in silico approach to identify and characterize the bzip19 gene in cereals. Through BLASTp in Phytozome database, 33 bzip19 genes were identified on the genomes of ... more

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Inflammation; Oxidative stress; Probucol; Spinal cord injury

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β-amyloid peptides (Aβs) can exert neurotoxic effects through induction of oxidative damage, whereas lipoic acid (LA), a powerful antioxidant, can alleviate oxidative damage. In this study, we explored the effect and mechanism of action of LA on beta-amyloid-intoxicated C6 glioma cells. Cells were randomly divided into three groups: control (vehicle), Aβ, and LA + Aβ. The LA + Aβ ... more

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W.Z. Li; X.H. Wang; H.X. Zhang; S.M. Mao; C.Z. Zhao; W.Z. Li; X.H. Wang; H.X. Zhang; S.M. Mao; C.Z. Zhao; W.Z. Li; X.H. Wang; H.X. Zhang; S.M. Mao; C.Z. Zhao
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At present, the use of nanoparticles is a controversial topic, especially when analyzing their effects in human tissues. Nanoparticles (NPs) can cause oxidative stress by increasing membrane lipids peroxidation and reactive oxygen species, and decreasing intracellular glutathione. Oxidative stress plays an important role in cell signaling and inflammatory responses. It can result in ... more

J. Jiménez-Villarreal; D.I. Rivas-Armendáriz; R.D.Arellano Pérez-Vertti; O. Calderón; R. García-Garza; N.D. Betancourt-Martínez; L.B. Serrano-Gallardo; J. Morán-Martínez
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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons and lacks an effective treatment. The disease pathogenesis has not been clarified at present. Pathological transactive response DNA-binding protein 43 (TDP-43) plays an important role in the pathogenesis of ALS. Nuclear translocation of nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is ... more

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Biochemical markers; Genetic polymorphisms; Oxidative stress; Schizophrenia

We evaluated the association of glutathione S-transferase polymorphisms (GSTT1 and GSTM1) and oxidative stress biomarkers in patients with schizophrenia. A total of 162 subjects were studied: 53 had schizophrenia (Total Study Group-TSG), and 109 without the disorder (Total Control Group-TCG). To analyze oxidative stress, TSG was distributed into ... more

L. Forner; T.N. Andreguetto; A.M. Lopes; P. Buosi; F.A. Borghi; I.S. Facincani; R. Fernandes-Ferreira; C.I.F. Oliveira-Brancati; E.A. de Almeida; A.A. Felício; D.P. Martins; G.M.A. Filho; D.R.S. Souza

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