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E.Y. Yvamoto; R.F. Ferreira; V. Nogueira; M.A.S. Pinhel; G.D. Tenani; J.G.S.C. Andrade; M.E.L. Baitello; M.L. Gregório; P.S. Fucuta; R.F. Silva; D.R.S. Souza; R.C.M.A. Silva
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Hepatocellular carcinoma; HLA-DP; Meta-analysis; SNP

The association between the HLA-DP single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 and hepatocellular carcinoma (HCC) has been reported, but results have been inconclusive and controversial. Therefore, to investigate the relationship between these HLA-DP SNPs and HCC susceptibility, a meta-analysis of studies published before January 2014 was carried out ... more

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Osteopontin (OPN) plays an important role in the metastasis and recurrence of tumors after resection of hepatocellular carcinoma (HCC). In this study, the down-regulation effect on OPN expression in HCC cells of RNA interference (RNAi) molecules designed to target different segments of OPN was investigated to identify a more effective site for OPN knockdown. Specific small interfering ... more

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Hepatocellular carcinoma; Prognostic value; Serum B7-H4

B7-H4 is member of the B7 family that negatively regulates the immune response, which are important for fine-tuning of the tumor microenvironment. Dysregulation of B7-H4 expression has been associated with tumor progression. However, expression level of B7-H4 in hepatocellular carcinoma (HCC) tissues is still a controversial topic. In addition, whether serum B7-H4 expression of HCC ... more

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We constructed hepatocellular carcinoma (HCC) cells that stably express stathmin with a Ser25 phosphorylation site mutation (stathmin S25A). We used the polymerase chain reaction for site-directed mutagenesis, constructed a stathmin S25A plasmid, and verified the results by restriction enzyme cleavage and sequencing technology. Using the liposome transfection method, stathmin wild-type ... more

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M.W. Peng; S.Q. Lu; J. Liu; C.Y. Dong; M.W. Peng; S.Q. Lu; J. Liu; C.Y. Dong; M.W. Peng; S.Q. Lu; J. Liu; C.Y. Dong
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Apoptosis; Hepatocellular carcinoma; Proliferation; ST2825

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