Research Article

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Meat quality traits are very important in the poultry industry. To identify single nucleotide polymorphisms (SNPs) and candidate genes affecting meat quality traits, a genome-wide association study was performed using the Illumina chicken 60K SNP beadchip in Jinghai yellow chicken. Four meat quality traits were measured. Two SNPs reached 5% Bonferroni genome-wide significance (P < 1. ... more

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Age-related macular degeneration; Atrophic macular degeneration; Genome-wide association study; Oldest old; SNP

The aim of this study was to identify disease-associated loci in oldest old Han Chinese with atrophic age-related macular degeneration (AMD). This genome-wide association study (GWAS) only included oldest old (≥95 years old) subjects in Rugao County, China. Thirty atrophic AMD patients and 47 age-matched non-AMD controls were enrolled. The study subjects underwent a complete ophthalmic ... more

T.Q. Zhou; H.J. Guan; J.Y. Hu
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Genome-wide association study; Meat pH; SNP; Swine

Meat pH is an important factor influencing meat quality traits in swine. This study evaluated a large number of genetic variants that covered all of the swine chromosomal regions. Approximately 68,000 single nucleotide polymorphisms (SNPs), found on Illumina Porcine SNP chips, were tested for associations with meat pH values. A genome-wide association study (GWAS) found that 19 SNPs on ... more

H.Y. Chung; K.T. Lee; G.W. Jang; J.G. Choi; J.G. Hong; T.H. Kim
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Body weight; Genome-wide association study; Jinghai yellow chicken; PLINK; Single-nucleotide polymorphism

Growth is one of the most economically important traits in the poultry industry. In this study, we identified single-nucleotide polymorphisms (SNPs) and candidate genes associated with growth traits of the Jinghai Yellow chicken. Genome-wide association studies were conducted using the Illumina 60 K SNP Chicken array to genotype 400 Jinghai Yellow chickens. For each bird, the body weights ... more

G.X. Zhang; Q.C. Fan; T. Zhang; J.Y. Wang; W.H. Wang; Q. Xue; Y.J. Wang
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Venous thromboembolism (VTE) is a multifactorial disorder involving both acquired and genetic risk factors. The common genetic factors in Western populations have been studied and reported for several decades, while studies on Asian populations are relatively scarce. Evidence suggests that the prevalence and genetic risk factors of VTE vary significantly among ethnic populations. In this ... more

S.S. Huang; Y. Liu; Z.C. Jing; X.J. Wang; Y.M. Mao; S.S. Huang; Y. Liu; Z.C. Jing; X.J. Wang; Y.M. Mao
12/02/2016
Animals; Body weight; Cattle; Genome-wide association study; Genotype; Models, Biological; Phenotype; Polymorphism, Single Nucleotide; Quantitative trait loci

This study aimed to investigate the predictability of a phenotype when using a dynamic model of cattle growth. Genotypic and phenotypic information on Nellore (Bos indicus) cattle were used in a genome-wide association analysis designed to contrast the biological interpretation of core parameters [conversion efficiency of metabolizable energy to net energy for gain (k) and adjusted final ... more

M.C. Freua; M.H.A. Santana; R.V. Ventura; J.B.S. Ferraz
3/22/2017
Animals; Biomarkers; Chickens; China; Female; Genome-wide association study; Haplotypes; Linkage disequilibrium; male; Polymorphism, Single Nucleotide; Quantitative trait loci; Quantitative Trait, Heritable; Reproduction; Selective breeding

Reproductive traits have long been studied and have an important influence on chicken breeding. To identify quantitative trait loci affecting reproductive traits, a genome-wide analysis of a Chinese chicken breed was performed to analyze age at first egg body weight at first egg, first egg weight, egg weight at the age of 300 days, egg weight at the age of 462 days, egg number at the age of ... more

Q.C. Fan; P.F. Wu; G.J. Dai; G.X. Zhang; T. Zhang; Q. Xue; H.Q. Shi; J.Y. Wang
4/13/2017
Animals; Animals, Inbred Strains; Ear; Extracellular Matrix Proteins; Gene expression profiling; Genome-wide association study; Intercellular Signaling Peptides and Proteins; Methionine Sulfoxide Reductases; Quantitative trait loci; RNA, Messenger; Swine

Porcine ear size is an important characteristic for distinguishing among pig breeds. In a previous genome-wide association study of porcine ear size, LEM domain-containing 3 (LEMD3), methionine sulfoxide reductase B3 (MSRB3), high mobility group AT-hook 2 (HMGA2), and Wnt inhibitory factor 1 (WIF1) were implicated as important candidate genes for ear size. This study investigated the ... more

L.C. Zhang; J. Liang; L. Pu; Y.B. Zhang; L.G. Wang; X. Liu; H. Yan; L.X. Wang
4/13/2017
Animals; Body composition; Body size; Breeding; Cattle; Genome-wide association study; Genotype; Polymorphism, Single Nucleotide; Quantitative Trait, Heritable

In arid and semi-arid zones, animal health and production are closely correlated with body conformation traits. These selected traits, in turn, allow livestock to adapt unfavorable soil and environmental conditions. The primary objective of this study was to perform a genome-wide association analysis for a set of sampled and imputed SNPs with 16 conformation traits in a population of Holstein ... more

M.E. González; V.M. González; M.F. Montaño; G.E. Medina; P. Mahadevan; C. Villa; R. Villa
06/29/2017
Animals; Cattle; Female; Genome-wide association study; Genotype; Lactation; Longevity; Milk; Quantitative trait loci; Quantitative Trait, Heritable; Reproduction; Selective breeding

In this study, we estimated the genetic parameters and identified the putative quantitative trait loci (QTL) associated with the length of productive life (LPL), days open (DO), and 305-day milk yield for the first lactation (FM305) of crossbred Holstein dairy cattle. Data comprising 4,739 records collected between 1986 and 2004 were used to estimate the variance-covariance components using ... more

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