Research Article

Related GMR Articles

12/07/2015
Hepatocellular carcinoma; Meta-analysis; T241M polymorphism; XRCC3

Numerous studies have evaluated the association between the X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3) T241M polymorphism and hepatocellular carcinoma (HCC) risk. However, the results of such investigations have proved inconsistent. Therefore, we performed a meta-analysis of the association between this polymorphism and HCC risk in the Chinese ... more

R.B. Ji; Y.S. Qian; A.R. Hu; Y.R. Hu
07/14/2015
COPD; Meta-analysis; rs3795879; SERPINE2; SNP

The present study aimed to investigate the effects of the rs3795879 polymorphism of the SERPINE2 gene on the development of chronic obstructive pulmonary disease (COPD) based on a systematic meta-analysis. An extensive literature search was performed to retrieve previously published case-control studies on the polymorphisms of SERPINE2 in COPD patients. Odds ratios (ORs ... more

D.B. Tian; S.X. Cai; G.C. Pan; Y.F. Zhang; J.H. Xiao
12/17/2015
CYP1B1; Meta-analysis; Primary open-angle glaucoma; SNP

Mutations in the CYP1B1 gene were detected in primary open-angle glaucoma (POAG) patients. However, the association between these mutations and the incidence of POAG remains to be elucidated. Here, we have conducted a meta-analysis to analyze this correlation, using relevant studies obtained from an extensive search of various electronic databases, including EMBase, Web of ... more

Z. Wang; M. Li; L. Li; H. Sun; X.Y. Lin
12/21/2015
Alpha-fetoprotein; Hepatitis C virus; Hepatocellular carcinoma; Polymorphism; Serum level; VEGF

We evaluated the influence of the vascular endothelial growth factor (VEGF) -C936T polymorphism on prognosis of hepatocellular carcinoma (HCC), cirrhosis, and hepatitis C virus (HCV) infection. Serum VEGF and alpha-fetoprotein (AFP) levels were determined and used to characterize sensitivity and specificity. A total of 285 subjects were studied: 68 HCC, 118 cirrhosis, 43 HCV, and 56 healthy ... more

E.Y. Yvamoto; R.F. Ferreira; V. Nogueira; M.A.S. Pinhel; G.D. Tenani; J.G.S.C. Andrade; M.E.L. Baitello; M.L. Gregório; P.S. Fucuta; R.F. Silva; D.R.S. Souza; R.C.M.A. Silva
12/07/2015
A1298C polymorphism; Hepatocellular carcinoma; Methylenetetrahydrofolate reductase (MTHFR)

The A1298C polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene has been reported to be associated with hepatocellular carcinoma (HCC), but there are conflicting results from previous studies. The present study aimed to investigate the association between this polymorphism and the risk of HCC using a meta-analysis of the published studies. Published literature ... more

W. Chang; Q. Meng; J.H. Liu; L.X. Wu; Y. Chen; S.D. Chen
11/19/2015
Down-regulation effect; Hepatocellular carcinoma; Osteopontin; RNA interference

Osteopontin (OPN) plays an important role in the metastasis and recurrence of tumors after resection of hepatocellular carcinoma (HCC). In this study, the down-regulation effect on OPN expression in HCC cells of RNA interference (RNAi) molecules designed to target different segments of OPN was investigated to identify a more effective site for OPN knockdown. Specific small interfering ... more

F. Lin; C.M. Huang; J. Cao; Z.H. Pei; W.L. Gu; S.F. Fan; K.P. Li; C.M. Lin
10/30/2015
Genetics; Hepatocellular carcinoma; KRAS; Polymorphisms

KRAS, also known as V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, acts as an intracellular signal transducer. The oncogenic KRAS mutation is an essential step in the development of many types of human cancers, including hepatocellular carcinoma. Here we aimed to investigate the relationship between KRAS rs712 polymorphisms and hepatocellular carcinoma ... more

D. Xiong; Y.P. Song; W. Xiong; Y.D. Liang
10/21/2015
Hepatocellular carcinoma; Prognostic value; Serum B7-H4

B7-H4 is member of the B7 family that negatively regulates the immune response, which are important for fine-tuning of the tumor microenvironment. Dysregulation of B7-H4 expression has been associated with tumor progression. However, expression level of B7-H4 in hepatocellular carcinoma (HCC) tissues is still a controversial topic. In addition, whether serum B7-H4 expression of HCC ... more

S.A. Zhang; Z.X. Wu; X. Zhang; Z.Y. Zeng; D.L. Li
10/05/2015
Hepatocellular carcinoma; Phosphorylation; Site-directed mutagenesis; Stathmin

We constructed hepatocellular carcinoma (HCC) cells that stably express stathmin with a Ser25 phosphorylation site mutation (stathmin S25A). We used the polymerase chain reaction for site-directed mutagenesis, constructed a stathmin S25A plasmid, and verified the results by restriction enzyme cleavage and sequencing technology. Using the liposome transfection method, stathmin wild-type ... more

J. Du; Z.H. Tao; J. Li; Y.K. Liu; L. Gan
03/18/2016
Hepatitis B virus; Hepatocellular carcinoma; IL-10; Polymorphism

We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms of IL-10 (-592G/A, -819T/C, and -1082A/C) in the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The study included 173 HBV-related HCC patients and 182 healthy controls. A polymerase chain reaction-restriction fragment length polymorphism ... more

M.W. Peng; S.Q. Lu; J. Liu; C.Y. Dong; M.W. Peng; S.Q. Lu; J. Liu; C.Y. Dong; M.W. Peng; S.Q. Lu; J. Liu; C.Y. Dong

Pages