Research Article

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12/14/2015
Bladder cancer; NAT2; NAT2 slow acetylation

The incidence of bladder cancer is closely associated with exposure to aromatic amines, that can cause cancer only after metabolic activation regulated by N-acetyl transferase 1 and 2 (NAT1 and NAT2). Many studies have indicated that slow acetylation of NAT2 increases the risk of bladder cancer. The major risk factor is tobacco smoke; however, some studies have failed to prove this. This study ... more

Y. An; H. Li; K.J. Wang; X.H. Liu; M.X. Qiu; Y. Liao; J.L. Huang; X.S. Wang
12/07/2015
Biomarker; Bladder cancer; MicroRNA-100; Prognosis

We investigated the clinical significance and prognostic value of microRNA-100 (miR-100) in bladder cancer. Quantitative real-time polymerase chain reaction was used to analyze the expression of miR-100 in 92 pairs of human bladder cancer and adjacent normal tissue samples. Overall survival (OS) curves were plotted using the Kaplan-Meier method and were evaluated for statistical ... more

Y.H. Cao; H.H. Zhang; H.F. Xu; Y.J. Duan; Q. Li; B. Huang
11/23/2015
Bladder cancer; Meta-analysis; MYC; rs9642880[T] allele

A single nucleotide polymorphism of MYC rs9642880 (G>T) at the 8q24.1 locus is thought to be associated with bladder cancer risk based on the results of genome-wide association studies, but the results remain inconclusive. To assess the association between rs9642880[T] allele and bladder cancer risk, we performed this meta-analysis including 18 case-control studies and ... more

Y. Zhao; J.G. Qi; N. Yang; Y.L. Lin; J. Liang; X. Zhu
09/28/2015
Bifidobacteria; Enterocolitis; Necrotizing; Newborn; Rats; Toll-like receptor

We established a necrotizing enterocolitis (NEC) rat model and explored the role of bifidobacteria in the intestines of the rats and its regulation on intestinal Toll-like receptors (TLRs). Seventy-five newborn Sprague-Dawley rats were randomly divided into 5 groups (15 rats/group): group A, artificial feeding group (formula-fed); group B, NEC model (LPS + formula-fed); group C, ... more

W. Zhou; H. Lv; M.X. Li; H. Su; L.G. Huang; J. Li; W.M. Yuan
12/21/2015
Bleomycin; Idiopathic pulmonary fibrosis; Lung fibrosis; Toll-like receptor

The specific role of Toll-like receptor 4 (TLR4) in bleomycin-induced lung fibrosis of mice, a model of human idiopathic pulmonary fibrosis, has not been characterized. We injected bleomycin intratracheally into TLR4 knockout (TLR4-/-) and wild-type (WT) mice. Twenty-one days after injection, mice were sacrificed and their lungs were harvested for pathological, hydroxyproline, ... more

X.X. Li; D.Y. Jiang; X.X. Huang; S.L. Guo; W. Yuan; H.P. Dai
07/14/2016
Hepatic cirrhosis; Hepatocellular carcinoma; Innate immunity; Toll-like receptor

Toll-like receptors (TLRs) can specifically identify pathogen-associated molecular patterns (PAMPs) by recognizing structural patterns in diverse microbial molecules, and can provide an effective defense against multiple microbial infectious. A variety of TLRs can be expressed on the surface of liver parenchymal as well as nonparenchymal cells. Kupffer cells are a type of hepatic ... more

L. Sun; J.J. Dai; W.F. Hu; J. Wang; L. Sun; J.J. Dai; W.F. Hu; J. Wang
12/28/2015
Biomarker; Bladder cancer; Dickkopf-1; Prognosis

Dickkopf-1 (DKK-1) is a secreted protein that inhibits Wnt signaling. However, the clinical significance and prognostic value of serum DKK-1 levels have not been previously investigated in bladder cancer in Chinese patients. Blood samples were taken from 94 consecutive patients diagnosed with bladder cancer and 60 healthy control subjects. Serum DKK-1 expression levels were measured by ... more

D.K. Sun; L. Wang; J.M. Wang; P. Zhang
04/26/2016
Bladder cancer; CYP1A2; Polymorphism; Risk

To date, no study has investigated the association between CYP1A2-163C/A polymorphism and bladder cancer risk in a Chinese population. Here, we extracted genomic DNA from peripheral white blood cells, and differentiated CYP1A2 alleles by polymerase chain reaction-based restriction fragment length polymorphism methods. Differences in genotype frequencies between the cases ... more

Y.L. Song; L. Wang; J.C. Ren; Z.H. Xu; Y.L. Song; L. Wang; J.C. Ren; Z.H. Xu; Y.L. Song; L. Wang; J.C. Ren; Z.H. Xu
11/03/2016
Bladder cancer; Clinical pathological parameters; miR-3658; Tumor progression

Despite increasing advances in surgical techniques and adjuvant chemotherapies, bladder cancer remains the ninth leading cause of male malignancy-associated deaths worldwide. Several microRNAs (miRNAs) have been identified to be closely associated with the progression and prognosis of, and response to treatments in various human cancers. However, few studies have ... more

Y.J. Chen; H.F. Wang; M. Liang; R.C. Zou; Z.R. Tang; J.S. Wang; Y.J. Chen; H.F. Wang; M. Liang; R.C. Zou; Z.R. Tang; J.S. Wang
10/19/2015
Coat color; meat quality; Native pig breeds; PCR-RFLP; Vertebra number

Mutations in melanocortin 1 receptor (MC1R) gene and v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT) gene have been shown to affect coat color patterns in pigs. Additional functional marker genes, such as insulin like growth factor-2 (IGF2) and orphan nuclear receptor, germ cell nuclear factor (NR6A1), have been described for ... more

P. Klomtong; K. Chaweewan; Y. Phasuk; M. Duangjinda

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