Research Article

Related GMR Articles

12/22/2015
Axon regeneration; Cell transplantation; Erythropoietin; Neural stem cells; Spinal cord injury

We investigated the effect of neural stem cells (NSC) and erythropoietin (EPO) on axon regeneration in adult rats with transected spinal cord injury, and provided an experimental basis for clinical treatment. Forty Wistar rats with T10-transected spinal cord injury were randomly divided into four groups of ten rats: a control group (group A), an NSC-transplant group (group B), an NSC- ... more

Y. Zhao; Y. Zuo; X.L. Wang; H.J. Huo; J.M. Jiang; H.B. Yan; Y.L. Xiao
10/30/2015
Acute myocardial infarction; Apoptosis; Cell transplantation; Myoblast; Sphingosine-1-phosphate

In this study, we investigated the effects of sphingosine-1-phosphate (S1P) combined with myoblast transplantation on the treatment of acute myocardial infarction and provided a foundation for its clinical application. A rat model of acute myocardial infarction was established by ligating the anterior descending branch of the coronary artery. Serum-free media, myoblasts, myoblasts with ... more

H. Yu; P.L. Chen; Y. Zhao; X. Gu; W. He; Z. Gong
08/07/2015
BMP-2/4; Noggin; Spinal cord injury

We investigated local changes in BMP-2/4 expression in rat spinal cords 1 week following injury to study the damage effects of BMP-2/4 in spinal cord injury (SCI). Sprague Dawley rats (45, 4 months old) were randomized into three groups comprising 15 rats each: a SHAM group, an SCI without noggin group (SCIO), and an SCI with noggin group (SCID). The SCIO and SCID groups were subjected to ... more

Z.S. Cui; P. Zhao; C.X. Jia; H.J. Liu; R. Qi; J.W. Cui; J.H. Cui; Q. Peng; B. Lin; Y.J. Rao
07/17/2015
Inflammation; Oxidative stress; Probucol; Spinal cord injury

To investigate the effects of probucol on the treatment of spinal cord injury in rat, 80 rats were randomly divided into two groups of 40: a group treated with probucol and a control group. Allen’s method was used to establish a rat model of spinal cord injury. After establishment, probucol (500 mg·kg-1·day-1) was intraperitoneally injected into the treatment group ... more

W.B. Zhu; Y.H. Wang; G.F. Sun; J.H. Wu
10/28/2015
Muscle basal lamina; Neural stem cells; Olfactory ensheathing cells; Spinal cord injury; Transplantation

We examined the effect of muscle basal lamina (MBL) with neural stem cells (NSCs) and olfactory ensheathing cells (OECs) on spinal cord injury repair. Seventy-two Sprague-Dawley rats were subjected to spinal cord hemisection and divided into 6 groups. In blank control group (group A), the ends of the spinal cord hemisection model were flushed with physiological saline. In NSC ... more

X.W. Kang; J.L. Hu; S.K. Wang; J. Wang
03/28/2016
Apoptosis; Signal transducers and activators of transcription-1 (STAT1); Spinal cord injury

Spinal cord injury (SCI) is typically caused by trauma or disease, and it severely affects patients’ motor function. The relationship between signal transducers and activators of transcription-1 (STAT1) and neuronal death after cerebral focal ischemia has been comprehensively studied, but its role in SCI remains largely unknown. This study investigated the protective effect of an STAT1 ... more

Y.X. Wu; C.Z. Gao; K.L. Fan; L.M. Yang; X.F. Mei; Y.X. Wu; C.Z. Gao; K.L. Fan; L.M. Yang; X.F. Mei; Y.X. Wu; C.Z. Gao; K.L. Fan; L.M. Yang; X.F. Mei