Research Article

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Ras-related protein 25 (Rab25) is involved in many human malignancies. However, its role in chemotherapy response and prognosis in advanced non-small cell lung cancer (NSCLC) remains unknown. Therefore, we investigated the relationship between Rab25 and chemotherapy sensitivity and prognosis in NSCLC. Rab25 expression was assessed using immunohistochemistry in 324 advanced NSCLC patients ... more

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Adenocarcinoma; Colorectal cancer; GA733 family; RT-PCR

GA733-1/-2/-3 genes have been detected in various types of cancer, although their role has not been fully clarified. GA733-2 and GA733-1 have been correlated with lymph node metastases in laryngeal cancer and liver metastases, respectively. Only a few studies have elucidated the mechanisms regulating GA733-1/-2 expression and their effect on colorectal cancer. ... more

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Dendritic cell; ELISA; gδ T cell; LPS-induced lung injury model; RT-PCR

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X.L. Chen; J. Li; G.G. Xu; H.X. Li; J. Guo; X.L. Chen; J. Li; G.G. Xu; H.X. Li; J. Guo; X.L. Chen; J. Li; G.G. Xu; H.X. Li; J. Guo
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Fermentation is an important industrial process for microbial metabolite development and has wide applications in various fields. Aspergillus is the most important genus of fungi used for the production of microbial enzymes such as cellulase. The Aspergillus genome encodes various cellulolytic enzymes. In this study, we assayed the gene expression ... more

M.A. Mahmoud; M.R. Al-Othman; A. -El-Aziz; H.A. Metwaly; H.A. Mohamed
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Circulating tumor cells; Lung cancer; Non-small cell lung cancer

We explored the expression and clinical significance of circulating tumor cells (CTCs) in patients with advanced non-small cell lung cancer (NSCLC). Sixty-six patients with advanced NSCLC at the Oncology Department of Jinzhou Hospital were selected as an observation group between February and December 2013. Healthy volunteers and 20 benign lung disease patients were taken as a control ... more

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Concurrent chemoradiotherapy; Cytokine-induced killer cells; Dendritic cells; Non-small cell lung cancer

To compare the efficacy of dendritic and cytokine-induced killer cells (DC-CIK) therapy combined with concurrent radiochemotherapy on stage IIIB non-small cell lung cancer. Sixty-three patients with stage IIIB non-small cell lung cancer were randomly divided into the study and control groups. The study group, comprising 30 patients, was treated with DC-CIK combined with docetaxel- ... more

X.P. Zhu; Y.H. Xu; J. Zhou; X.F. Pan
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Microwave ablation; Non-small cell lung cancer; Vascular endothelial growth factor

We aimed to analyze the changes of serum vascular endothelial growth factor (VEGF) before and after microwave ablation (MWA) in patients with stage IIIB-IV non-small cell lung cancer (NSCLC), and to observe the effects of MWA combined with chemotherapy on short-term therapeutic efficacy and long-term survival. Concentrations of serum VEGF in 20 healthy subjects were considered as controls ... more

Y.H. Sun; P.Y. Song; Y. Guo; M. Pang; W.N. He; W.H. Zhang; L.J. Sheng
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EGFR gene promoter; Epidermal growth factor receptor; Methylation; Non-small cell lung cancer

We investigated the methylation state of the epidermal growth factor receptor (EGFR) gene promoter in non-small cell lung cancer (NSCLC) and analyzed its effect on tumor biology. We enrolled 120 patients with NSCLC who had been confirmed by pathologic diagnosis and had been operated on. The methylation states of the EGFR gene promoter were detected and analyzed and a prognosis was given. ... more

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CYP1 A1; Gene polymorphism; Non-small cell lung cancer; Smoking

Many studies have shown that genetic factors, environmental factors, and bad living habits, especially smoking, are risk factors for lung cancer. However, not all smokers develop lung cancer, which may be related to different genetic backgrounds. Currently, most research has investigated the GSTM1, XRCC1, XRCC3, CYP2D6, and C188T genes. Little ... more

Y.Q. Xie; J.M. Chen; Y. Liu

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