Research Article

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03/31/2016
Colorectal cancer; Matrix metalloproteinase-9; Polymorphism -1562C/T

We examined whether the allelic and/or genotypic profile of locus -1562C/T of the matrix metalloproteinase (MMP-9) gene influences the protein expression levels of MMP-9 in patients with colorectal cancer (CRC) compared with controls. A total of 104 patients with CRC and 84 controls were evaluated. Peripheral blood was collected from both groups and DNA extraction was performed for -1562C ... more

C.R. Hoelzle; K.C.S.F. Magalhães; S.S. Carvalho; G.A. Santos; I.M. Maia; M.C.P.S. Sousa; J.S. Andrade-Filho; G.M.G. Cruz; R.T. Simões; C.R. Hoelzle; K.C.S.F. Magalhães; S.S. Carvalho; G.A. Santos; I.M. Maia; M.C.P.S. Sousa; J.S. Andrade-Filho; G.M.G. Cruz; R.T. Simões; C.R. Hoelzle; K.C.S.F. Magalhães; S.S. Carvalho; G.A. Santos; I.M. Maia; M.C.P.S. Sousa; J.S. Andrade-Filho; G.M.G. Cruz; R.T. Simões
04/30/2020
CD1 antigen presenting molecules; Colorectal cancer; Genetic polymorphism; Saudi Arabia

Cluster of differentiation 1 (CD1) is antigen-presenting molecule involved in the presentation of lipid and glycolipid antigens to specific T cells and natural killer T cells. They exhibit a low rate of polymorphism compared to classical major histocompatibility complex presenting molecules. In this case control study, we examined a possible association of genetic ... more

S. Alomar; J. Al-Tamimi; T. Almanaa; A. Al-jurayyan; L. Mansour
12/02/2015
Genetic polymorphism; Matrix metalloproteinase-3; mRNA expression; Rheumatoid arthritis

Matrix metalloproteinase-3 (MMP-3) can mediate the occurrence and development of rheumatoid arthritis (RA). The MMP3 promoter gene exhibits polymorphism with 5A/6A alleles. We investigated the correlation between the expression of MMP3 gene polymorphism and RA to provide an objective basis for prognosis evaluation. We enrolled 80 RA patients and 80 healthy subjects. Enzyme- ... more

M.J. Ma; H.C. Liu; X.Q. Qu; J.L. Wang
12/09/2015
NLRP3; Polymorphism; Primary gout

We conducted a case-control study to investigate the association between 3 common NALP3 polymorphisms (rs10754558, rs7512998, and rs12137901) and the susceptibility to primary gout. A total of 320 patients with primary gout and 320 controls were included in this study. The genotyping of NALP3 rs10754558, rs7512998, and rs12137901 were conducted by polymerase chain ... more

L.F. Wang; Y.J. Ding; Q. Zhao; X.L. Zhang
07/13/2015
Colorectal cancer; Epithelial cell adhesion molecule; Immunohistochemistry

We investigated the relationship between the expression of epithelial cell adhesion molecule (EpCAM) and the occurrence and development of colon cancer. Fifty colon cancer tissues and adjacent normal tissues were collected, while 40 normal intestinal mucosa tissues were collected as the blank group. EpCAM expression was detected by immunohistochemistry and the patients were followed-up to ... more

X.B. Chai; R.F. Song; F. Xu
12/22/2015
Biomarker; Colorectal cancer; Diagnostic marker; Meta-analysis; MicroRNA-29a

Previous studies have revealed that the expression level of microRNA-29a (miR-29a) was remarkably different in colorectal cancer (CRC) patients and healthy controls, indicating that miR-29a can be used as a diagnostic marker of CRC, but the results have been inconsistent. We conducted this meta-analysis to assess the diagnostic performance of blood-based miR-29a for CRC. We performed a ... more

M.L. Zhi; Z.J. Liu; X.Y. Yi; L.J. Zhang; Y.X. Bao
12/14/2015
BRAFV600E mutation; Colorectal cancer; Histopathological criteria; KRAS mutations

KRAS and BRAF mutations are well-recognized molecular alterations during colorectal carcinogenesis, but there is little agreement on their effect on tumor characteristics. Therefore, we aimed to evaluate the distribution of the most common KRAS and BRAF mutations in Greek patients with colorectal cancer and their possible associations with clinical ... more

M. Samara; K. Kapatou; M. Ioannou; Ε. Kostopoulou; R. Papamichali; C. Papandreou; A. Athanasiadis; G. Koukoulis
12/02/2015
Angiopoietin-2; Colorectal cancer; Diagnostic biomarker

We examined the expression of angiopoietin-2 in serum samples from patients diagnosed with colorectal cancer and healthy volunteers and investigated the feasibility of using angiopoietin-2 as a potential diagnostic colorectal cancer biomarker. Enzyme-linked immunosorbent assays were used to measure the levels of angiopoietin-2 in patients with colorectal cancer and healthy control subjects. ... more

Z.Q. Wang; X.L. Sun; H.L. Su; X.F. Liu; Y.J. Xuan; S.Q. Yu
12/02/2015
Colorectal cancer; Meta-analysis; Non-metastatic protein 23; Pathological characteristics; Prognosis

The current meta-analysis was performed to investigate the association between non-metastatic protein 23 (NM23) expression, tumor pathology, and disease prognosis in colorectal cancer (CRC) among Asians. English and Chinese language-based electronic databases (e.g., PubMed, EBSCO, Ovid, Springerlink, Wiley, Web of Science, Wanfang databases, China National Knowledge Infrastructure, VIP ... more

J.W. Fu; X.Q. Chu
12/01/2015
Colorectal cancer; Mexican population; Polymorphisms; RUNX3 gene

We analyzed a possible association between RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer (CRC). Genomic DNA samples were obtained from the peripheral blood of 176 Mexican patients with CRC at diagnosis and from 195 individuals that formed the control group. The polymorphisms were detected by polymerase chain reaction-restriction fragment ... more

S. Suárez-Villanueva; M.L. Ayala-Madrigal; J. Peregrina-Sandoval; N. Macias-Gomez; R. Ramírez-Ramírez; R. Muñiz-Mendoza; J.M. Moreno-Ortiz; M. Centeno-Flores; V. Maciel-Gutiérrez; E. Cabrales; M. Gutierrez-Angulo

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