Research Article

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Exercise; Genetic risk factor; Nutritional intervention; Obesity

We evaluated the response of individuals with metabolic syndrome to lifestyle modification intervention and examined the influence of the 48867A>C (Asp358Ala) IL6R (rs2228145) polymorphism on this response. Participants were randomly divided into two groups: NI, nutritional intervention; NIE, nutritional intervention and exercise practice. Intervention lasted three months and ... more

V.R.A. Vargas; S.L. Bonatto; F.E. Macagnan; A.M.P. Feoli; C.S. Alho; N.D.V. Santos; V.M. Schmitt
12/19/2016
Athletes; Cell Hypoxia; Cell proliferation; Cells, Cultured; Endothelial progenitor cells; Exercise; Gene expression; Humans; Lipoproteins; Skiing

In this study, we compared the functional properties of endothelial progenitor cells (EPCs) derived from halfpipe-snowboarding athletes who train under hyperoxic conditions with those derived from normal subjects who lived under normoxic conditions. Peripheral blood-derived EPCs were isolated from both halfpipe-snowboarding athletes and normal humans. Cellular growth dynamics, lipoprotein ... more

Y.H. Zhao; J.C. Kan; Y.F. Wang; W.J. Guan; Z.Q. Zhu
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Calcium and vitamin D; Cross- sectional; Exercise; Fosamax drug; Lifestyle; Menopause; Osteoporosis; Prevalence; T-score

Osteoporosis is a common pathology and a cause of disability and reduced quality of life invarious developing countries.  An urgent issue in this context is the study of risk factors for osteoporosis, especially those that can be modified. We conducted a cross-sectional study in Vietnam.  The study was conducted in the city of Vinh and involved 2065 respondents who ... more

S.C. Thuc; T.H.L. Thi; M.T.N. Thi; H.D. Vinh
05/31/2021
Cholesterol; Diet; Exercise; Hypertension risk; Lifestyle

Hypertension (or high blood pressure) is a common problem throughout the world, including Vietnam, especially for people over 65. This pathology has various contributing risk factors. Understanding them can help in hypertension awareness, treatment, and control, especially in low-income countries. To help provide more useful information for our population, we ... more

T.D. Cam; D.T. Huyen; H.T. Le; P.T. Trung; T.A. Hoang
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Aged; Aged, 80 and over; Arthroplasty, Replacement, Knee; Biomarkers; Chemokine CXCL13; Female; Humans; Interleukin-1beta; male; Middle Aged; Osteoarthritis, Knee; Postoperative Complications; Synovial fluid; Tumor necrosis factor-alpha

Knee osteoarthritis (KOA) is a common degenerative joint disease and immune system dysregulation has been implicated in its pathogenesis. The effect of arthroscopic knee surgery, an important method for KOA diagnosis and treatment, on the expression of immune regulators remains poorly understood. We aimed to investigate the clinical efficacy of such surgery and its impact on IL-1β, CXCL13, and ... more

Z.M. Li; M. Li
09/22/2015
Cartilage; Chondrocytes; Fibroblast growth factor 1; Osteoarthritis

Osteoarthritis (OA) is a degenerative disease of the systemic joint that involves multiple cytokines and growth factors. Fibroblast growth factor 1 (FGF-1) is increased in patients with rheumatic arthritis. The aim of this study was to determine whether the expression and secretion of FGF-1 differed in synovial tissue from patients with late stage OA from that in normal tissues. We selected ... more

R. Li; B. Wang; C.Q. He; Y.Q. Yang; H. Guo; Y. Chen; T.H. Du
07/03/2015
Cardiopulmonary function; Interleukin; Osteoarthritis; Regulatory T cells

In this study, we observed changes in CD4+ CD25+ Foxp3+ Treg expression in rats with osteoarthritis (OA) to explore the role that CD4+ CD25+ Foxp3+ Treg plays in the decline in the condition of OA rats. Thirty rats were randomly divided into 2 groups equally ... more

S.Y. Guo; Y.J. Ding; L. Li; T. Zhang; Z.Z. Zhang; E.S. Zhang
11/13/2015
Cartilage oligomeric matrix protein; Matrix metalloproteinase-3; Osteoarthritis; Reversible

The main pathological characteristic of osteoarthritis (OA) is cartilage damage. We explored cartilage oligomeric matrix protein (COMP) and matrix metalloproteinase-3 (MMP-3) changes during articular cartilage injury and repair. Rabbits were randomly divided into the following: a blank control group; groups M1, M2, and M3, in which breaking was performed for 2, 4, and 6 weeks, ... more

X.Q. Chu; J.J. Wang; L.D. Dou; G. Zhao
11/13/2015
Articular cartilage bone; Correlation analysis; Interleukin-6; Osteoarthritis

This study aimed to investigate the expressional profile of interleukin-6 (IL-6) in articular cartilage bone of osteoarthritis (OA) patients and its correlation with OA. A total of 30 articular cartilage bone samples from knee OA patients, which were collected by knee arthroscopy or articular surgery, comprised the study group, and 30 samples of normal articular cartilage tissue comprised ... more

X.Q. Qu; W.J. Wang; S.S. Tang; Y. Liu; J.L. Wang
10/21/2015
Cyclooxygenase-2; Osteoarthritis; Rheumatoid arthritis; Synovial tissues

In this study, we investigated the differential expression profiles of cyclooxygenase-2 (COX-2) mRNA and proteins in osteoarthritis (OA) and rheumatoid arthritis (RA) patients to elucidate the role of COX-2 expression in the pathogenesis and development of these diseases and to provide novel drug targets for treating arthritis. A total of 60 patients who received arthroscopic surgeries ... more

H.W. Fan; G.Y. Liu; C.F. Zhao; X.F. Li; X.Y. Yang