Research Article

Related GMR Articles

12/09/2015
Celiac disease; HLA-DQ; IL-6; TNF-α

The aim of this research was to study polymorphisms in the genes encoding cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in patients with celiac disease (CD) antigens DQ2 (DQ2-positive) or DQ8 (DQ8-positive). We compared the results with healthy controls to determine whether any of the polymorphisms have a role in susceptibility to CD. A case-control of 192 patients ... more

R.Mde Albuque Maranhão; F.A.Martins Esteves; S. Crovella; L. Segat; P.R.Eleutério Souza
08/28/2015
Han people; Ischemic stroke; Mongol; Phosphodiesterase 4D gene; Single nucleotide polymorphism

We investigated single nucleotide polymorphisms (SNP) at 87 sites of the phosphodiesterase 4D (PDE4D) gene in Mongol and Han patients with ischemic stroke in Inner Mongolia. SNPs in 226 patients with ischemic stroke (case group, 110 Mongol patients, 116 Han patients) and 220 patients without neurological disease (control group, 102 Mongol patients, 118 Han patients) were detected ... more

J.P. Shi; W.D. Chen; J.Q. Zhou; M.M. Xue; F. Xue; H.Z. Li; Z.P. Xu
03/31/2016
IL10 -1082A/G; IL10 -592C/A; Ischemic stroke; Polymorphism

We investigated the possible association between two single nucleotide polymorphisms of IL10 (-1082A/G and -592C/A) and susceptibility to ischemic stroke. In total, 335 patients with proven ischemic stroke and 335 control subjects were recruited from Xinxiang Central Hospital between March 2013 and May 2015. The IL10 -1082A/G and -529C/A polymorphisms were investigated ... more

W.Z. Li; C.Y. Gao; W.L. He; H.M. Zhang; W.Z. Li; C.Y. Gao; W.L. He; H.M. Zhang; W.Z. Li; C.Y. Gao; W.L. He; H.M. Zhang
03/29/2021
Hemorrhagic stroke; Ischemic cerebrovascular accident; Ischemic stroke; Risk factors analysis; Stroke risk factors

Stroke is one of the leading causes of death both globally and in Southeast Asia, which is confirmed by high values: 5 million and 500 thousand deaths annually, respectively. The situation in Vietnam is also critical. We have systematized and studied the risk factors in patients with ischemic stroke in Phu Tho Province General Hospital. This was a prospective ... more

N.H. Ngoc; N.Q. An
12/17/2015
IL-6; miR-31; NF-κB; Peripheral blood mononuclear cells; TNF-α; Tuberculosis

We investigated the diagnostic values of microRNA-31 in peripheral blood mononuclear cells (PBMCs) for pediatric pulmonary tuberculosis in Chinese patients. Sixty-five children with TB were selected for this study, which was conducted at the Department of Infectious Diseases People’s Hospital of Laiwu City between December 2013 and December 2014. Sixty healthy children, selected in ... more

J.X. Wang; J. Xu; Y.F. Han; Y.B. Zhu; W.J. Zhang
03/22/2016
IL-6; Immunohistochemistry; Invasive pituitary adenomas; TNF-α

The aim of this study was to investigate expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in invasive pituitary adenomas (IPAs). The streptavidin peroxidase immunohistochemical method was employed to detect their expression in 40 cases of IPA and 40 of non-invasive pituitary adenoma (NIPA). TNF-α and IL-6 were found to be upregulated in IPA tissue compared with that ... more

J.L. Wu; J.Y. Qiao; Q.H. Duan; J.L. Wu; J.Y. Qiao; Q.H. Duan; J.L. Wu; J.Y. Qiao; Q.H. Duan
11/03/2016
ICAM-1; IL-6; IL-8; Myocardial ischemia-reperfusion; NF-κB; Total peony glycoside

Early recovery of myocardial perfusion is beneficial for myocardial ischemia. However, ischemia-reperfusion (I/R) may exacerbate myocardial injury. Research shows that total peony glucoside (TPG) can inhibit ischemic myocardial cell apoptosis. However, whether it can ameliorate I/R injury remains poorly understood. This study explored the effect of TPG pretreatment ... more

L. Lu; P. Wei; Y. Cao; Q. Zhang; M. Liu; X.D. Liu; Z.L. Wang; P.Y. Zhang; L. Lu; P. Wei; Y. Cao; Q. Zhang; M. Liu; X.D. Liu; Z.L. Wang; P.Y. Zhang
09/28/2015
Case-control study; Dental caries; Gene polymorphism; Vitamin D receptor

Environmental influences on the development and progression of dental caries are well known; however, there is little evidence of a genetic component imparting susceptibility to dental caries. The aim of this study was to investigate the relationship between a single nucleotide polymorphism in the vitamin D receptor TaqI locus and dental caries susceptibility in a Chinese ... more

X.P. Hu; Z.Q. Li; J.Y. Zhou; Z.H. Yu; J.M. Zhang; M.L. Guo
09/09/2015
Arg188His; Gene polymorphism; Ovarian cancer; X-ray repair cross-complementing group 2 (XRCC2)

Numerous studies have evaluated the association between the Arg188His polymorphism of the X-ray repair cross-complementing group 2 (XRCC2) gene and ovarian cancer risk. However, the specific association is still controversial. This meta-analysis was therefore designed to clarify these controversies. Relevant case-control studies were enrolled in the meta-analysis. Quality ... more

M. Zhai; Y. Wang; M.F. Jiang
09/09/2015
Chronic obstructive pulmonary disease; Gene polymorphism; Meta-analysis; Vitamin D-binding protein

Gene polymorphism of vitamin D-binding protein (VDBP) correlates with chronic obstructive pulmonary disease (COPD), but the results remain inconclusive. We aimed to explore the association between VDBP gene polymorphism and COPD. We searched MEDLINE, Embase, Web of Science, and China National Knowledge Infrastructure for publications addressing the association between VDBP gene ... more

Y.L. Wang; H. Kong; W.P. Xie; H. Wang

Pages