Research Article

Related GMR Articles

Differentiation; Ganglioside GM1; Neural growth factor; Neural stem cell; Proliferation

Neurogenesis, recovery from nerve injury, neurodegeneration, and Parkinson’s disease affect people’s health, yet the underlying molecular mechanisms remain elusive. Here, we investigated the effect of ganglioside GM1 and neural growth factor (NGF) on neural stem cell (NSC) proliferation and differentiation in vitro to provide a scientific basis for comprehensive treatment of ... more

Q. Wang; Y.H. Song; Z. Tang; Z.P. Wang; Q. Xu; N. Bao; Q. Wang; Y.H. Song; Z. Tang; Z.P. Wang; Q. Xu; N. Bao
Hyperphosphatemia; Model; Rat

We established a rat model of hyperphosphatemia and investigated the systemic effects of high phosphorus (P). Sprague Dawley rats were randomly divided into high (HP), low (LP), and normal (NP) P groups (N = 12 each), which received injections of fructose diphosphate sodium, or were fed self-manufactured low phosphorus or normal diets, respectively. In each group, 4 rats were sacrificed ... more

C. Zhang; Y. Shao; Q.G. Zhu; Y. Li; C.L. Jin; H.P. Wang; L. Zhou; C. Yu; Y.K. Zhao; G.J. Yuan; X.P. Hu; L. Zhang; H. Wang
Erectile dysfunction; Hypoxia; Nitric oxide synthase; Rat

We examined the relationship between chronic hypoxia and erectile dysfunction in rat and its possible pathogenic mechanism. Forty-eight white male adult Sprague-Dawley rats were randomly divided into a test group and a control group. In accordance with the experimental time (2, 6, and 10 weeks), each group was divided into 3 subgroups, with 8 rats in each subgroup. Rats in the test group ... more

D.P. Yu; X.H. Liu; A.Y. Wei
Cardiomyocyte; Heart development; Intercalated disc; N-cadherin; Rat

We investigated the expression and distribution of N-cadherin during the development of a rat heart. Immunohistochemistry (IHC) was performed to detect the expression and distribution of N-cadherin in the myocardial tissues of rats at embryonic day 18 (E18d), postnatal day 5 (P5d), postnatal day 19 (P19d), postnatal day 40 (P40d), and postnatal year 1 (P1y). Reverse transcription polymerase ... more

L.M. Mu; W.F. Wang; H. Zheng; Z.K. Guo; G.M. Zhang
Bone marrow cells proliferation; Fructus polygoni orientalis; Hepatocyte proliferation; Liver regeneration; Rat

To study the effect of fructus polygoni orentalis extract (EFPO) on liver regeneration and proliferation of bone marrow cells on rat model of partial hepatectomy, EFPO was extracted, and 60 adult male Wistar rats were divided randomly into 6 experimental groups. Rats were treated with intergastric administration (ig) with EFPO daily. All rats were euthanized 7 days after ... more

J.Y. Yang; J.S. Wang; H.B. Liu
AQP-1; Barrier function; Hydrogen; Lung; Rat; Sepsis

This study aimed to explore the protective effect of hydrogen and to investigate the underlying mechanism of its preliminary effect on the alveolar epithelial barrier function in septic rats. Forty-five male Sprague-Dawley rats were divided randomly into three groups (N = 15): control [saline injection (intraperitoneal, ip), air drawing; SA], acute lung injury group [ ... more

L.D. Liu; X.Y. Wu; B.D. Tao; N. Wang; J. Zhang; L.D. Liu; X.Y. Wu; B.D. Tao; N. Wang; J. Zhang; L.D. Liu; X.Y. Wu; B.D. Tao; N. Wang; J. Zhang