Research Article

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The association between the rs2230199 C>G single nucleotide polymorphism (SNP) in complement component 3 and age-related macular degeneration (AMD) risk has been examined extensively but the results are not consistent among studies. The aim of this study was to perform a meta-analysis of all available studies on this SNP in relation to AMD. The comprehensive databases of PubMed, ... more

M.X. Zhang; X.F. Zhao; Y.C. Ren; T.T. Geng; H. Yang; T. Feng; T.B. Jin; C. Chen
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The objective of this study was to examine the effects of the type and intensity of nutritional stress, and of the statistical treatment of the data, on the genotype x environment (G x E) interaction for tropical maize (Zea mays). For this purpose, 39 hybrid combinations were evaluated under low- and high-nitrogen and -phosphorus availability. The plants were harvested at the V6 ... more

I.S.C. Granato; R. Fritsche-Neto; M.D.V. Resende; F.F. Silva; I.S.C. Granato; R. Fritsche-Neto; M.D.V. Resende; F.F. Silva
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Censored data; GBLUP; Mixed model; Survival models

Age at the time of slaughter is a commonly used trait in animal breeding programs. Since studying this trait involves incomplete observations (censoring), analysis can be performed using survival models or modified linear models, for example, by sampling censored data from truncated normal distributions. For genomic selection, the greatest genetic gains can be ... more

V.S. Santos; M. Filho; M.D.V. Resende; C.F. Azevedo; P.S. Lopes; S.E.F. Guimarães; F.F. Silva
09/25/2015
Coronary artery disease; IL-17A; IL-17F; Polymorphism

A case-control study was conducted to investigate the association between genetic variants of IL-17A rs2275913 and IL-17F rs763780 and the development of coronary artery disease (CAD) in a Chinese population. A total of 306 individuals with CAD and 306 unaffected individuals were enrolled from the Zhengzhou People’s Hospital between May 2012 and May 2014. The IL-17A ... more

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DNA repair genes; Osteosarcoma; Overall survival; Polymorphism

We conducted a perspective study to investigate the role of ERCC1 (rs11615), ERCC2 (rs13181 and rs1799793), ERCC4 (rs1800067), and ERCC5 (rs17655) in NER pathway in the prognosis of osteosarcoma patients. In total, 146 osteosarcoma patients were recruited between 2008 and 2013. ERCC1 rs11615, ERCC2 rs13181 and rs1799793, ERCC4 rs1800067, and ERCC5 rs17655 gene polymorphisms were assessed ... more

M.J. Wang; Y. Zhu; X.J. Guo; Z.Z. Tian
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Chemotherapy; Clinical outcome; Glutathione S-transferases; Polymorphism

The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymor­phisms in the clinical response to chemotherapy and treatment outcome of patients with breast cancer. A total of 262 subjects were randomly selected from among patients with a histologically confirmed breast cancer. The genotypes of GSTM1, ... more

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Cancer risk; Polymorphism; Renal cell carcinoma; Vascular endothelial growth factor

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broiler; Candidate gene; Polymorphism; Production trait; QTL

Genetic selection for production traits has resulted in a rapid improvement in animal performance and development. Previous studies have mapped quantitative trait loci for body weight at 35 and 41 days, and drum and thigh yield, onto chicken chromosome 4. We investigated this region for single nucleotide polymorphisms and their associations with important economic traits. Three positional ... more

F. Pértille; R. Zanella; A.M. Felício; M.C. Ledur; J.O. Peixoto; L.L. Coutinho
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Advanced non-small cell lung cancer; Clinical outcome; GSTP1; Polymorphism; XRCC1

We investigated the association between the polymorphisms GSTP1 rs1695 and XRCC1 rs1799782 and rs25487 and the clinical outcome of patients with non-small cell lung cancer (NSCLC) receiving cisplatin-based chemotherapy. Genotyping of GSTP1 rs1695 and XRCC1 rs1799782, and rs25487 was conducted by polymerase chain reaction-restriction fragment length ... more

J.Y. Liu; L.R. Li; Q.M. Liu
08/28/2015
Breast cancer; Glutathione S-transferases; Polymorphism

The current study aimed at evaluating the associa­tion between GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymorphisms and clinical response to chemotherapy and treatment outcome of breast cancers patients. Genotyping of GSTP1 rs1695, GSTT1 deletion, and GSTM1 deletion was performed by Polymerase Chain Reaction Restriction Fragment Length Polymor­phism (PCR-RFLP) assay. ... more

X. Wang; Z.H. Huang

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