Research Article

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03/24/2016
Apoptosis; Membrane permeability; Mitochondrial dysfunction; QGY-7701 cells; Resveratrol

This study aims to evaluate the cytotoxicity of resveratrol on QGY-7701 cells via a cell viability assay, and determine the cytological alterations and damages that result. Resveratrol was found to inhibit QGY-7701 cell growth and decrease their viability in a remarkably dose-dependent manner. Resveratrol exposure also induced an increase in Caspase-3 activity and a decrease in Bcl-2, ... more

J.P. Li; Q. Ma; C.M. Chen; J.P. Li; Q. Ma; C.M. Chen; J.P. Li; Q. Ma; C.M. Chen
11/29/2011
COX; Diabetes mellitus; MMP-9; NF-κB; Resveratrol; SIRT1

Resveratrol (RSV) has a beneficial role in the prevention of diabetes and alleviates some diabetic complications, such as cardiomyopathy. We investigated cyclooxygenase-1 (COX-1), COX-2, nuclear factor κB (NF-κB), matrix metalloproteinase-9 (MMP-9), and sirtuin 1 (SIRT1) mRNA expression levels in heart tissue after RSV treatment in streptozotocin (STZ)-induced diabetic rats. After ... more

A.S. Yar; S. Menevse; E. Alp
01/21/2014
AMPK; Heart failure; Resveratrol; SIRT1

Reduced AMP-activated protein kinase (AMPK) expression has been shown to play a significant role in the cardiac dysfunction in heart failure. This study was designed to examine the effect of resveratrol, a potent activator of silent information regulator (SIRT1), on cardiac function and AMPK expression in heart failure. Adult male rat left anterior descending arteries were ligated, and ... more

X.S. Gu; Z.B. Wang; Z. Ye; J.P. Lei; L. Li; D.F. Su; X. Zheng
06/11/2015
Chronic myeloid leukemia; Growth and proliferation; Imatinib mesylate; K562 cell; Resveratrol

To investigate the effect of treatment with resveratrol combined with imatinib mesylate on human chronic myelogenous leukemia K562 cell growth inhibition and apoptosis, in vitro cultured human chronic myelogenous leukemia K562 cells were incubated with different concentrations of resveratrol and imatinib mesylate when the cells were in the logarithmic phase. Next, the cell growth ... more

X.J. Wang; Y.H. Li
04/25/2016
COPD; MMP-1; MMP-3; MMP-9; rs1799750; rs3918242

Correlations between genetic polymorphisms of three matrix metalloproteinase (MMP) genes and susceptibility to chronic obstructive pulmonary disease (COPD) were investigated. Relevant case-control studies were selected using rigorous inclusion and exclusion criteria. The comprehensive Meta-analysis 2.0 software was used to conduct the statistical analysis. An odds ratio with 95% ... more

S. Jiang; Z.H. Yang; Y.Y. Chen; Z. He; Y. Zhou; Y. Gao; Q. Zhang; M.Q. Tan; S. Jiang; Z.H. Yang; Y.Y. Chen; Z. He; Y. Zhou; Y. Gao; Q. Zhang; M.Q. Tan; S. Jiang; Z.H. Yang; Y.Y. Chen; Z. He; Y. Zhou; Y. Gao; Q. Zhang; M.Q. Tan
05/20/2016
Breast cancer; Proliferation; Resveratrol; Tristetraprolin

Resveratrol is a natural compound that exhibits anticancer properties. Previous studies have proved that it can inhibit the proliferation of breast cancer cell lines and upregulate some cytokines such as cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). The initiation and progression of cancer are associated with the abnormal expression of multiple cytokines. ... more

C. Li; C. Tang; G. He; C. Li; C. Tang; G. He
09/27/2017
Arachis; Genotype; Plant Leaves; Plant Proteins; Resveratrol; RNA, Messenger; Stilbenes; Tetraploidy; Transcriptional activation; Ultraviolet Rays

Resveratrol is an antioxidant that is a promising antitumoral, cardioprotective and neuroprotective agent. It has been found in a restricted number of plants including peanut (Arachis hypogaea L.) and its wild relatives. The objective of this study was to understand the relationship between resveratrol content and the expression of putative resveratrol synthase genes in four Arachis genotypes ... more

P.A.S.V. Carvalho; A.C. Brasileiro; S. Leal-Bertioli; D.J. Bertioli; J.P. Silva; T.S. Agostini-Costa; M.A. Gimenes
09/09/2015
Global cerebral ischemia-reperfusion; Immunohistochemistry; Intermittent hypobaric hypoxia

This study was aimed at understanding the effect of intermittent hypobaric hypoxia preconditioning (IHHP) on neuroglobin (NGB) and Bcl-2 expression in the hippocampal CA1 region of rats following global cerebral ischemia-reperfusion. Wistar rats were randomly divided into sham, IHHP control, global cerebral ischemia-reperfusion (IR group), and IHHP+IR groups. The four-vessel occlusion rat ... more

Q. Wu; K.X. Yu; Q.S. Ma; Y.N. Liu
07/13/2015
Colorectal cancer; Epithelial cell adhesion molecule; Immunohistochemistry

We investigated the relationship between the expression of epithelial cell adhesion molecule (EpCAM) and the occurrence and development of colon cancer. Fifty colon cancer tissues and adjacent normal tissues were collected, while 40 normal intestinal mucosa tissues were collected as the blank group. EpCAM expression was detected by immunohistochemistry and the patients were followed-up to ... more

X.B. Chai; R.F. Song; F. Xu
12/29/2015
ELISA; Immunohistochemistry; Polyclonal antibody; Porcine β-defensin 2; Western blotting

Porcine β-defensin 2 (pBD2) is an antimicrobial peptide in pigs that plays an important role in the immune system by preventing bacterial invasion. To produce an anti-pBD2 antibody, which is not commercially available, we expressed and purified a soluble, his-tagged version of pBD2 (his-pBD2). Purified pBD2 was injected into New Zealand white rabbits to generate polyclonal antiserum. Anti ... more

Y.Y. Bao; L. Li; H. Zhang; C.Y. Gao; C.B. Xiao; C.L. Li

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