Research Article

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09/22/2015
Chemotherapy; ERCC1; ERCC2; Osteosarcoma; Overall survival; Single nucleotide polymorphism

We assessed the role of single nucleotide polymorphisms (SNPs) in ERCC1 and ERCC2 genes in the clinical outcomes for osteosarcoma patients receiving cisplatin-based treatment. A perspective study was conducted on 260 patients with osteosarcoma during 2010 and 2011. A polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was used to assess ... more

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Chemotherapy; Clinical outcome; Glutathione S-transferases; Polymorphism

The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymor­phisms in the clinical response to chemotherapy and treatment outcome of patients with breast cancer. A total of 262 subjects were randomly selected from among patients with a histologically confirmed breast cancer. The genotypes of GSTM1, ... more

J. Wang; T. Wang; G.Y. Yin; L. Yang; Z.G. Wang; X.B. Bu
12/28/2015
Acute leukemia; Chemotherapy; DR5; TRAIL

We investigated the roles of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptor death receptor 5 (DR5) in the onset of acute leukemia and changes in their expression during chemotherapy. Bone marrow samples from 16 patients newly diagnosed with acute leukemia were collected before chemotherapy. Bone marrow samples from patients with non-hematologic ... more

S.M. Chen; H. Sun; Y.F. Liu; J. Ma; Q.T. Zhang; J. Zhu; T. Li
12/11/2015
Breast cancer; Chemotherapy; Glutathione S-transferases; Polymorphism

The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 polymorphisms in the clinical response to chemotherapy and treatment outcome of breast cancer. The GSTM1, GSTT1, and GSTP1 IIe105Val polymorphism genotypes were analyzed using polymerase chain reaction coupled with restriction fragment ... more

P. Yuan; L. Yuan; B.L. Xu; C.Z. Wang; H.Z. Yang; Y. Li
03/18/2016
Breast neoplasms; Chemotherapy; DNA damage; Germline micronucleus; Sister chromatid exchange

The aim of the present study was to investigate DNA damage in peripheral blood lymphocytes of breast cancer (BC) patients before and after administration of chemotherapy. We analyzed the frequency of sister chromatid exchange (SCE), occurrence of micronuclei (MN), and lymphocyte proliferation rate index (PRI) as cytogenetic markers in 28 female BC patients before and after chemotherapy, ... more

P.A. Koşar; M. Koçer; D.A. Çelik; N. Ozcelik; P.A. Koşar; M. Koçer; D.A. Çelik; N. Ozcelik; P.A. Koşar; M. Koçer; D.A. Çelik; N. Ozcelik
12/28/2015
MicroRNA; miR-494; Pancreatic cancer; Prognosis; Survival

MicroRNA-494 (miR-494) expression is aberrant in various types of human cancer. However, the prognostic value of miR-494 in pancreatic cancer remains unclear. The level of miR-494 expression was determined in 99 pairs of primary pancreatic cancer and their corresponding, adjacent non-tumor tissues by using quantitative reverse transcriptase polymerase chain reaction. We also analyzed the ... more

Y.B. Ma; G.X. Li; J.X. Hu; X. Liu; B.M. Shi
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Cancer; Long non-coding RNA; MALAT-1; Prognosis; Survival

The long non-coding RNA MALAT-1 plays an important role in cancer prognosis. The present research aimed to elucidate its precise predictive value in various human carcinomas. A quantitative meta-analysis was performed by searching PubMed, Embase, Web of Science, and Cochrane Library (most recently, January 2015) databases, and extracting data from studies that investigated the ... more

J. Wang; A.M. Xu; J.Y. Zhang; X.M. He; Y.S. Pan; G. Cheng; C. Qin; L.X. Hua; Z.J. Wang; J. Wang; A.M. Xu; J.Y. Zhang; X.M. He; Y.S. Pan; G. Cheng; C. Qin; L.X. Hua; Z.J. Wang; J. Wang; A.M. Xu; J.Y. Zhang; X.M. He; Y.S. Pan; G. Cheng; C. Qin; L.X. Hua; Z.J. Wang
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Epithelial-mesenchymal transition; Immunohistochemistry; Survival; Vimentin

Vimentin is a cytoskeletal protein belonging to a family of intermediate filaments whose expression has been studied in human cancers due to its association with the mesenchymal epithelial transition, a cancer reactivation event that results in complex alterations in the expression of genes involved in the invasion and metastasis processes. Studies on the ... more

F.C. Santana; J.E.P. Ramos; N.A. Nogueria; L.S.D. Líbera; T. Aparecida; S.H. Rabelo; V.A. Saddi
03/25/2021
Carcinoma; CO2 transoral laser microsurgery; Larynx; Survival; T1- T2

Laryngeal cancer remains one of the most common head and neck tumors. In the treatment of this disease, it is important to assess the overall survival when using transoral СО2 laser microsurgery. The aim of the research was to make an evaluation of treatment of patients with laryngeal cancer undergoing CO2 laser transoral microsurgery. Fifty ... more

L.M. Ky; P.V. Huu; N.X. Quang; T. Hai; M.Q. Hoan; N. BacHai; N.D. Phuc

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