Research Article

Related GMR Articles

06/11/2015
Endothelial cells; Hydrogen; Lipopolysaccharide; Sepsis; Vascular endothelial-cadherin

We observed the effect of hydrogen-rich medium on lipopolysaccharide (LPS)-induced human umbilical vein endothelial cells (HUVECs), hyaline leukocyte conglutination, and permeability of the endothelium. Endotheliocytes were inoculated on 6-well plates and randomly divided into 4 groups: control, H2, LPS, LPS+H2, H2, and LPS+H2 in saturated ... more

Y. Yu; W.N. Wang; H.Z. Han; K.L. Xie; G.L. Wang; Y.H. Yu
09/22/2015
DNA methylation; IGF2R; Lung; mRNA expression; Transgenic cloned dairy goats

Dairy goat is a good model for production of transgenic proteins in milk using somatic cell nuclear transfer (SCNT). However, animals produced from SCNT are often associated with lung deficiencies. We recently produced six transgenic cloned dairy goats harboring the human lactoferrin gene, including three live transgenic clones and three deceased transgenic clones that died from ... more

Y.L. Zhang; G.M. Zhang; Y.J. Wan; R.X. Jia; P.Z. Li; L. Han; F. Wang; M.R. Huang
08/21/2015
Burn; Plasminogen activator inhibitor-1; Polymorphism; Sepsis

We investigated the association between plasminogen activator inhibitor-1 (PAI-1) polymorphisms and plasma PAI-1 level with sepsis in severely burned patients. A total of 182 patients with burn areas lager than 30% of the body surface area were enrolled in this study. Peripheral blood samples were obtained from 103 patients with sepsis (sepsis group) and 79 patients without sepsis ( ... more

Y.F. Chi; J.K. Chai; Y.M. Yu; H.M. Luo; Q.X. Zhang; R. Feng
12/28/2015
Candida parapsilosis; Outbreak; Preterm infants; Sepsis

In this article, we describe the first outbreak of Candida parapsilosis fungemia in our hospital. We examined a cluster of four nosocomial cases of C. parapsilosis fungemia that occurred in the neonatal intensive care unit (NICU) of the Affiliated Xingtai People’s Hospital of Hebei Medical University over a two-week period. We ascertained patient parameters including ... more

W. Guo; H.F. Gu; H.G. Zhang; S.B. Chen; J.Q. Wang; S.X. Geng; L. Li; P. Liu; X. Liu; Y.R. Ji; S.W. Li; L. Yang
09/22/2015
Hyperphosphatemia; Model; Rat

We established a rat model of hyperphosphatemia and investigated the systemic effects of high phosphorus (P). Sprague Dawley rats were randomly divided into high (HP), low (LP), and normal (NP) P groups (N = 12 each), which received injections of fructose diphosphate sodium, or were fed self-manufactured low phosphorus or normal diets, respectively. In each group, 4 rats were sacrificed ... more

C. Zhang; Y. Shao; Q.G. Zhu; Y. Li; C.L. Jin; H.P. Wang; L. Zhou; C. Yu; Y.K. Zhao; G.J. Yuan; X.P. Hu; L. Zhang; H. Wang
09/08/2015
Erectile dysfunction; Hypoxia; Nitric oxide synthase; Rat

We examined the relationship between chronic hypoxia and erectile dysfunction in rat and its possible pathogenic mechanism. Forty-eight white male adult Sprague-Dawley rats were randomly divided into a test group and a control group. In accordance with the experimental time (2, 6, and 10 weeks), each group was divided into 3 subgroups, with 8 rats in each subgroup. Rats in the test group ... more

D.P. Yu; X.H. Liu; A.Y. Wei
08/19/2015
Cardiomyocyte; Heart development; Intercalated disc; N-cadherin; Rat

We investigated the expression and distribution of N-cadherin during the development of a rat heart. Immunohistochemistry (IHC) was performed to detect the expression and distribution of N-cadherin in the myocardial tissues of rats at embryonic day 18 (E18d), postnatal day 5 (P5d), postnatal day 19 (P19d), postnatal day 40 (P40d), and postnatal year 1 (P1y). Reverse transcription polymerase ... more

L.M. Mu; W.F. Wang; H. Zheng; Z.K. Guo; G.M. Zhang
07/13/2015
Bone marrow cells proliferation; Fructus polygoni orientalis; Hepatocyte proliferation; Liver regeneration; Rat

To study the effect of fructus polygoni orentalis extract (EFPO) on liver regeneration and proliferation of bone marrow cells on rat model of partial hepatectomy, EFPO was extracted, and 60 adult male Wistar rats were divided randomly into 6 experimental groups. Rats were treated with intergastric administration (ig) with EFPO daily. All rats were euthanized 7 days after ... more

J.Y. Yang; J.S. Wang; H.B. Liu
10/21/2015
FCIR; Focal cerebral ischemia reperfusion; MK-801; Neural stem cell; Rat

We explored the relationship between MK-801 concentration and neural stem cell proliferation in rats with focal cerebral ischemia-reperfusion (FCIR). A total of 60 male Sprague Dawley rats were randomized into control (six rats), sham-operation (six rats), operation (12 rats), and MK-801 groups. The MK-801 group comprised 36 rats that were subjected to different doses of MK-801 (0.2, 0.4 ... more

Y.K. Gui; L.L. Su; X.L. Niu; P. Zeng; R.R. Fang; H.X. Lv; P. Zhang
10/19/2015
AQP-1; AQP-4; High altitude hypoxia; Lung injury

Aquaporin (AQP)-1 and AQP-4 expression in lung tissues of SD rats during high altitude hypoxic lung injury, and the relationship between AQP-1 and AQP-4 expression, and acute hypoxic lung injury was analyzed. Thirty six healthy SD rats were divided into hypoxia 1d, 2d, 3d, 5d, and 7d groups and control group (N = 6). Pathological changes in lung tissue were observed by hematoxylin and ... more

Y. Wu; C.Y. Pan; C.Z. Guo; Z.J. Dong; Q. Wu; H.M. Dong; W. Zhang