Research Article

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03/11/2016
Differentially expressed genes; MicroRNAs; RNA sequencing; Thyroid carcinoma; Transcription factors

In this study, we examined the molecular mechanism of thyroid carcinoma (THCA) using bioinformatics. RNA-sequencing data of THCA (N = 498) and normal thyroid tissue (N = 59) were downloaded from The Cancer Genome Atlas. Next, gene expression levels were calculated using the TCC package and differentially expressed genes (DEGs) were identified using the edgeR package. A co-expression ... more

J.C. Lu; Y.P. Zhang; J.C. Lu; Y.P. Zhang
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CD38; Chronic lymphocytic leukemia; Cytogenetic abnormalities; ZAP70

Chromosomal abnormalities and ZAP70 expression profile are two major independent prognostic markers in B-cell chronic lymphocytic leukemia. We investigated a possible correlation between these two markers. ZAP70 expression using real-time RT-PCR was examined in 20 B-cell chronic lymphocytic leukemia patients with del13q14, 13 patients with del11q22, 15 patients with trisomy 12, and 16 ... more

H. Teimori; M.T. Akbari; M. Hamid; M. Forouzandeh; E. Bibordi
04/30/2021
Brazilian population; Chronic lymphocytic leukemia; Genetic polymorphisms; Glutathione S-transferase

Genetic polymorphisms involved in carcinogen metabolism contribute to leukemogenesis risk. Epidemiological studies have revealed genetic alterations in chronic lymphocytic leukemia (CLL), including chromosome alterations, noncoding RNA alterations, and genetic polymorphisms. The bioactivation and detoxification of chemical agents is mediated by xenobiotic ... more

A.Ada S. Reis; K.C. de Alcântara; L.C.A. de Souza; H.G.C. Fontinele; D.L.C. de Farias; L.R.Bdos Anjos; daS. Santos
03/28/2016
Comparative study; Evolutionary rate; MicroRNA; Model species; Molecular evolution

MicroRNAs (miRNAs) are major post-transcriptional regulators of gene expression. In an attempt to gain insights into miRNAs at the macroevolutionary level, we performed a systematic analysis of miRNAs in six model organisms based on their evolutionary rates. First, we calculated their miRNA evolutionary rates, and found that they did not correlate with the complexity of the organisms. A ... more

X.F. Mao; Y.C. Cao; X.F. Mao; Y.C. Cao; X.F. Mao; Y.C. Cao
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Bioinformatics; Identification; MicroRNA; Middleware; RNA sequencing; Web server

This report describes the miRQuest - a novel middleware available in a Web server that allows the end user to do the miRNA research in a user-friendly way. It is known that there are many prediction tools for microRNA (miRNA) identification that use different programming languages and methods to realize this task. It is difficult to understand each tool and apply it to diverse datasets ... more

R.R. Aguiar; L.A. Ambrosio; G. Sepúlveda-Hermosilla; V. Maracaja-Coutinho; A.R. Paschoal; R.R. Aguiar; L.A. Ambrosio; G. Sepúlveda-Hermosilla; V. Maracaja-Coutinho; A.R. Paschoal; R.R. Aguiar; L.A. Ambrosio; G. Sepúlveda-Hermosilla; V. Maracaja-Coutinho; A.R. Paschoal
02/22/2016
Apoptosis; Epilepsy; Hippocampus; MicroRNA; Status epilepticus

Epilepsy is one of the most frequent neurological disorders. Recently, the regulation of microRNAs was found to be associated with epilepsy, but the molecular mechanism by which microRNA influences epilepsy process remains to be unveiled and the development of microRNA-based therapy requires more intensive research. In this study, five microRNAs with potential relevance to epilepsy were ... more

L. Ren; R. Zhu; X. Li; L. Ren; R. Zhu; X. Li
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Biomarker; Functional network; Heart disease; MicroRNA; Pathway

Deregulation of cardiac miRNA gene-regulatory networks is a feature of different heart diseases, including ischemic (ICM) and nonischemic (NICM) cardiomyopathy. Here, based on the paired miRNA and mRNA expression profiles in ICM and NICM, we identified the differentially expressed miRNAs and mRNAs and the expression signatures distinguishing ICM/NICM from control samples. Furthermore, we ... more

X. Li; C.Y. Liu; Y.S. Li; J. Xu; D.G. Li; D. Han; X. Li; C.Y. Liu; Y.S. Li; J. Xu; D.G. Li; D. Han; X. Li; C.Y. Liu; Y.S. Li; J. Xu; D.G. Li; D. Han
07/14/2016
Gastric cancer; MicroRNA; Polymorphism; Review

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules of about 22 nucleotides in length. miRNAs are highly conserved in both plants and animals, and function as gene regulators by binding to the 3'-untranslated region of target mRNAs for cleavage and/or translational repression. miRNA biogenesis, stability, and regulation of expression are strongly sequence dependent. Sequence ... more

B.W. Han; Z.H. Li; S.F. Liu; H.B. Han; S.J. Dong; H.J. Zou; R.F. Sun; J. Jia; B.W. Han; Z.H. Li; S.F. Liu; H.B. Han; S.J. Dong; H.J. Zou; R.F. Sun; J. Jia
09/25/2015
Colostrum; Goat; Mature milk; MicroRNA

Immune-related miRNAs in breast milk are extracellular miRNAs that are related to immune organ development and regulation of the immune function in infants and young animals. The goal of this study was to compare the expression levels of five immune-related miRNAs in breast milk in black goats, humans, and dairy cattle. The miRNAs from milk were extracted and the expression levels were ... more

R.S. Na; G.X. E; W. Sun; X.W. Sun; X.Y. Qiu; L.P. Chen; Y.F. Huang
08/28/2015
Differentially expressed gene; MicroRNA; Pancreatic adenocarcinoma

The main aim of this study was to explore the underlying molecular mechanisms and potential target molecules of pancreatic adenocarcinoma. The miRNA (GSE32678) and mRNA (GSE32676) expression profiles of patients with pancreatic ductal adenocarcinoma and healthy controls were downloaded from the Gene Expression Omnibus database. Differentially expressed miRNA and differentially expressed genes ... more

P.F. Liu; W.H. Jiang; Y.T. Han; L.F. He; H.L. Zhang; H. Ren

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