Research Article

Related GMR Articles

Coronary heart disease; Han Chinese population; Matrix metalloproteinase; Polymorphism

Coronary heart disease (CHD) has become a leading cause of human deaths worldwide. Recent studied showed that polymorphisms of the matrix metalloproteinase (MMP) genes played important roles in extracellular matrix remodeling and contribute to the pathogenesis of vascular diseases. Here, we investigated whether these MMP gene polymorphisms were associated with CHD in Han Chinese. Our case ... more

C.M. Wang; H.D. Ye; Y.R. Li; Q.X. Hong; L.L. Tang; A.N. Zhou; M.Q. Xu; S.W. Duan
Disc herniation; Gene expression; Matrix metalloproteinase; Polymorphism

The aim of this study was to identify the possible correlation between polymorphisms in matrix metalloproteinase (MMP)-1 and MMP-3 and their corresponding protein levels in disc tissues obtained from patients with lumbar disc herniation (LDH) using biochemical and immunohistochemical analyses. Blood and disc samples were obtained from 100 patients with LDH who ... more

B. Eser; O. Eser; Y. Yuksel; H. Aksit; E. Karavelioglu; M. Tosun; Z. Sekerci; B. Eser; O. Eser; Y. Yuksel; H. Aksit; E. Karavelioglu; M. Tosun; Z. Sekerci
Albuminuria; Essential hypertension; Lectin-like oxidized low-density lipoprotein receptor 1; Polymorphisms

Albuminuria is an independent predictor of renal and cardiovascular complications in hypertensive subjects. We previously showed that lectin-like oxidized low-density lipoprotein receptor 1 (OLR-1) polymorphisms at G501C are associated with susceptibility to essential hypertension and serum C-reactive protein levels. We have now investigated a possible association between OLR-1 polymorphisms ... more

X.W. Hou; Z.H. Hu; Y. Cui; W. Gao; S.P. Sun; N.F. Wang
Osteosarcoma; Polymorphisms; VEGF

The aim of this study was to assess the role of the VEGF -2578C/A, +936C/T, and -460T/C gene polymorphisms in the development of osteosarcoma. A total of 182 patients with osteosarcoma and 182 age- and gender-matched healthy controls were enrolled into our study during January 2011 and December 2013. Genotype frequencies of the VEGF -2578C/A and -460T/C alleles in controls ... more

H.F. Zhang; J.P. Yan; Y.S. Zhuang; G.Q. Han
Bone mineral density; Human leukocyte antigen-A; Polymerase chain reaction-sequence-based typing; Polymorphisms; Postmenopausal osteoporosis

Osteoporosis is a common disease characterized by low bone mineral density, deterioration in bone microarchitecture, and increased fracture risk and is more prevalent in postmenopausal women. HLA is a complex gene family; previous studies have shown that it plays an important role in the pathogenesis of osteoporosis among Japanese and Greek populations. Prompted by these findings ... more

S.M. Li; H. Guo; H.J. Yang; M.Q. Lv; D.X. Zhou
Folate pathway; Gastric adenocarcinoma; Polymorphisms

The folate metabolic pathway, which is involved in DNA synthesis and methylation, is associated with individual susceptibility to several diseases, including gastric tumors. In this study, we investigated four polymorphisms [thymidylate synthase enhancer region, single nucleotide polymorphism thymidylate synthase 5' (TS5'), TS3' untranslated region, and methylenetetrahydrofolate reductase ... more

M.D. Araújo; B.N. Borges; S. Rodrigues-Antunes; R.M.R. Burbano; M.L. Harada
Angiotensin-converting enzyme; Factor VII; Polymorphisms; Thrombosis; Tissue factor

Recent studies have shown an association between thrombosis and factor VII (FVII), tissue factor (TF), and angiotensin-converting enzyme (ACE). This suggests that individuals with FVII-402 G/A, FVII-401 G/T, TF+5466 A/G, and ACE-287 insertion/deletion (I/D) polymorphisms present an increased risk of venous thrombosis, heart disease, and ischemic stroke compared with controls. In this ... more

F.C.G. Evangelista; D.R.A. Rios; D.D. Ribeiro; M.G. Carvalho; L.M.S. Dusse; A.P. Fernandes; A.P. Sabino
Association; Chicken; Diplotype; GJA1; Growth traits; Polymorphisms

This study aimed to screen single nucleotide polymorphisms (SNPs) in the chicken gap junction protein alpha 1 (GJA1) gene, and to investigate their association with five growth traits measured in 269 chickens encompassing Chinese indigenous Beijing-You (BJY) and commercial Cobb broiler (CB) populations. Four variants were detected in the chicken GJA1 gene, in which one ... more

M. Shahjahan; R.R. Liu; G.P. Zhao; J.J. Zhang; M.Q. Zheng; Q.H. Li; J. Wen
Chinese population; Graves’ disease; Heat shock protein 70; Polymorphisms

Graves’ disease (GD) is a common autoimmune disease mainly affecting the thyroid. However, the correlation between the development of GD and HSP70 alleles has not been reported in the Chinese population. Therefore, the aim of this study was to investigate the association between HSP70 polymorphisms and GD in the Chinese population. A total of 153 patients with GD treated ... more

Y.P. Wang; Z. Tang; B.K. Peng; Q. Zhen; S.L. Zhou; X.F. Jin
AGER; Breast cancer; Lung cancer; Meta-analysis; Polymorphisms

We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), and China National ... more

N.C. Yin; X.P. Lang; X.D. Wang; W. Liu