Research Article

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MicroRNAs (miRNAs) are major post-transcriptional regulators of gene expression. In an attempt to gain insights into miRNAs at the macroevolutionary level, we performed a systematic analysis of miRNAs in six model organisms based on their evolutionary rates. First, we calculated their miRNA evolutionary rates, and found that they did not correlate with the complexity of the organisms. A ... more

X.F. Mao; Y.C. Cao; X.F. Mao; Y.C. Cao; X.F. Mao; Y.C. Cao
03/28/2016
Bioinformatics; Identification; MicroRNA; Middleware; RNA sequencing; Web server

This report describes the miRQuest - a novel middleware available in a Web server that allows the end user to do the miRNA research in a user-friendly way. It is known that there are many prediction tools for microRNA (miRNA) identification that use different programming languages and methods to realize this task. It is difficult to understand each tool and apply it to diverse datasets ... more

R.R. Aguiar; L.A. Ambrosio; G. Sepúlveda-Hermosilla; V. Maracaja-Coutinho; A.R. Paschoal; R.R. Aguiar; L.A. Ambrosio; G. Sepúlveda-Hermosilla; V. Maracaja-Coutinho; A.R. Paschoal; R.R. Aguiar; L.A. Ambrosio; G. Sepúlveda-Hermosilla; V. Maracaja-Coutinho; A.R. Paschoal
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Chronic lymphocytic leukemia; Differentially expressed genes; MicroRNA; Module analysis

Chronic lymphocytic leukemia (CLL) is a disease that involves progressive accumulation of nonfunctioning lymphocytes and has a low cure rate. There is an urgent requirement to determine the molecular mechanism underlying this disease in order to improve the early diagnosis and treatment of CLL. In this study, genes differentially expressed between CLL samples and age-matched controls were ... more

L. Dong; K.H. Bi; N. Huang; C.Y. Chen; L. Dong; K.H. Bi; N. Huang; C.Y. Chen; L. Dong; K.H. Bi; N. Huang; C.Y. Chen
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Biomarker; Functional network; Heart disease; MicroRNA; Pathway

Deregulation of cardiac miRNA gene-regulatory networks is a feature of different heart diseases, including ischemic (ICM) and nonischemic (NICM) cardiomyopathy. Here, based on the paired miRNA and mRNA expression profiles in ICM and NICM, we identified the differentially expressed miRNAs and mRNAs and the expression signatures distinguishing ICM/NICM from control samples. Furthermore, we ... more

X. Li; C.Y. Liu; Y.S. Li; J. Xu; D.G. Li; D. Han; X. Li; C.Y. Liu; Y.S. Li; J. Xu; D.G. Li; D. Han; X. Li; C.Y. Liu; Y.S. Li; J. Xu; D.G. Li; D. Han
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CXCR4; EGFR2; Endometriosis; MicroRNA; PTEN; VEGFA

We examined the aberrant microRNA (miRNA) expression profile responsible for the changes in angiogenesis observed in endometriotic lesions. This study revealed characteristic miRNA expression profiles associated with endometriosis in endometrial tissue and endometriotic lesions from the same patient, and their correlation with the most important angiogenic and fibrinolytic factors. miRNA ... more

R.Q. Yang; H. Teng; X.H. Xu; S.Y. Liu; Y.H. Wang; F.J. Guo; X.J. Liu; R.Q. Yang; H. Teng; X.H. Xu; S.Y. Liu; Y.H. Wang; F.J. Guo; X.J. Liu
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Cortical dysplasia; Epilepsy; Gene chip; PI3K-AKT signaling pathway

The aims of this study were to observe the differential expression of PI3K-AKT pathway-related genes in seizure-inducing brain lesions in type II focal cortical dysplasia, and to explore the relationship between gene expression and histological changes in dysplastic foci and their epileptogenic mechanism. Typical lesions in brain tissue from three patients with epilepsy induced by type II ... more

Y.X. Lin; K. Lin; X.X. Liu; D.Z. Kang; Z.X. Ye; X.F. Wang; S.F. Zheng; L.H. Yu; Z.Y. Lin
12/02/2016
Animals; Citalopram; Dementia, Vascular; Disease Models, Animal; Dopamine; Gene Expression Regulation; Hippocampus; Humans; Injections, Intraperitoneal; male; Neurons; Norepinephrine; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin; Treatment outcome

5-hydroxytryptamine receptor 1A (5-HT1AR) is closely associated with cognitive functions. Selective serotonin reuptake inhibitors (SSRIs) can protect individuals from brain damage following ischemia/hypoxia. To investigate the function of SSRIs in vascular dementia (VD), we established a rat model of VD, and observed the effect of SSRIs on the expression of 5-HT1AR mRNA and neurotransmitters. ... more

K. Guo; G. Yin; X.H. Zi; H.X. Zhu; Q. Pan
1/23/2017
Animals; Cognition Disorders; Disease Models, Animal; Gene expression; Hippocampus; HIV Envelope Protein gp120; Humans; Immunohistochemistry; Maze Learning; Rats; Receptors, Purinergic P2X7

To investigate the role of the P2X receptor in learning and memory dysfunction induced by HIV-1 envelope glycoprotein gp120 (gp120), we established HIV-1-associated dementia (HAD) animal models by intracerebroventricular (ICV) infusion of gp120 in rats. We observed gp120-induced cognitive dysfunction in the radial arm water maze test. Results showed that rats in the gp120 groups had longer ... more

Y. Liu; G.Q. Chen; B.Y. Liu; Q. Chen; Y.M. Qian; S.S. Qin; C.L. Liu; C.S. Xu
2/16/2017
Alzheimer disease; Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Humans; Maze Learning; Mice; MicroRNAs; Receptor, Cannabinoid, CB2

Alzheimer's disease (AD) is a neurodegenerative disorder, and is the most common type of dementia in the elderly population. Growing evidence indicates that microRNAs (miRNAs) play a crucial role in neuroinflammation associated with AD progression. In this study, we analyzed the expression of microRNA-139 (miR-139) as well as the learning and memory function in AD. We observed that the miR-139 ... more

Y. Tang; J.S. Bao; J.H. Su; W. Huang