Research Article

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We investigated the association between the polymorphisms GSTP1 rs1695 and XRCC1 rs1799782 and rs25487 and the clinical outcome of patients with non-small cell lung cancer (NSCLC) receiving cisplatin-based chemotherapy. Genotyping of GSTP1 rs1695 and XRCC1 rs1799782, and rs25487 was conducted by polymerase chain reaction-restriction fragment length ... more

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Numerous studies have evaluated the association between Arg399Gln polymorphism of DNA repair gene XRCC1 and cervical carcinoma risk. However, the specific association is still controversial. To assess the relationship between XRCC1 Arg399Gln polymorphism and cervical carcinoma, we conducted a comprehensive meta-analysis of 10 case-control studies with 2051 cervical carcinoma cases and ... more

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Gastric cancer; Genotype; Pre-miR-196a2; Rs11614913

We did a case-control study to provide a more comprehensive evaluation of the association of the pre-miR-196a2 rs11614913 polymorphism with gastric cancer. Between January 2013 and December 2014, 182 patients newly diagnosed with primary gastric cancer and 182 control subjects were recruited at Zhengzhou People’s Hospital. For SNP genotyping, we used the Assay Designer 3.1 to design the ... more

M. Li; R.J. Li; H. Bai; P. Xiao; G.J. Liu; Y.W. Guo; J.Z. Mei; M. Li; R.J. Li; H. Bai; P. Xiao; G.J. Liu; Y.W. Guo; J.Z. Mei; M. Li; R.J. Li; H. Bai; P. Xiao; G.J. Liu; Y.W. Guo; J.Z. Mei
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Lung cancer is the most common cancer occurring worldwide. The human X-ray repair complementing group 1 (XRCC1) gene is one of the most important candidate genes that influence the susceptibility to lung cancer. The objective of this study was to analyze the potential association between the c.1804C>A genetic variant of XRCC1 and lung cancer susceptibility. A total of ... more

J.J. Jin; H.Q. Wang; H.P. Kuang; B.B. Kang; Y.H. Liu; J. Wang; J.J. Jin; H.Q. Wang; H.P. Kuang; B.B. Kang; Y.H. Liu; J. Wang
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We conducted a case-control study to assess the role of the XRCC1 Arg399Gln, Arg280His, and Arg194Trp gene polymorphisms in pancreatic cancer susceptibility in a Chinese population. A total of 152 patients diagnosed with pancreatic cancer and 264 control subjects were enrolled in this study between March 2012 and October 2014. XRCC1 Arg399Gln, Arg280His, and Arg194Trp were genotyped ... more

L.J. Wang; H.T. Wang; X.X. Wang; L.J. Wang; H.T. Wang; X.X. Wang
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Gastric cancer; Meta-analysis; MicroRNA; Polymorphism

Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In this study, we assessed the ... more

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Gastric cancer; Invasion; miR-221; Proliferation; Propofol

Propofol is one of the extensively and commonly used intravenous anesthetic agents. The current study aimed to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms of this activity. The effects of propofol on SGC7901 and AGS cell proliferation, apoptosis, and invasion were detected by MTT assay, flow cytometric analysis, and matrigel ... more

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12/21/2015
Clinical outcome; ERCC1; ERCC2; Gastric cancer; Polymorphism

We performed a study to investigate the role of ERCC1 (rs11615, rs2298881, and rs3212986) and ERCC2 (rs13181, rs238406, and rs1799793) polymorphisms in the prognosis of gastric cancer. A total of 346 patients with gastric cancer were recruited between May 2009 and May 2012. Single nucleotide polymorphism genotyping was performed using the Sequenom MassARRAY platform. The GA+ ... more

W.H. Yu; Y.X. Wang; J.Q. Guo; Y.L. Wang; J.S. Zheng; K.X. Zhu
12/17/2015
ERCC1; ERCC2; Gastric cancer; Overall survival; Polymorphism; Response to chemotherapy

We investigate whether three common polymorphisms in ERCC1 and ERCC2 are predictor factors for the chemotherapy response, as well as the clinic outcome of patients with gastric cancer. Between May 2011 and May 2013, 263 patients with gastric cancer who were newly diagnosed by histopathology were enrolled in our study. Genotyping of the ERCC1 rs11615 and rs3212986, ... more

G. Zhong; H.K. Li; T. Shan; N. Zhang

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